Hypothermic oxygenated perfusion (HOPE) safely and effectively extends acceptable donor heart preservation times : Results of the Australian and New Zealand trial
Copyright © 2024 International Society for the Heart and Lung Transplantation. Published by Elsevier Inc. All rights reserved..
BACKGROUND: Cold static storage preservation of donor hearts for periods longer than 4 hours increases the risk of primary graft dysfunction (PGD). The aim of the study was to determine if hypothermic oxygenated perfusion (HOPE) could safely prolong the preservation time of donor hearts.
METHODS: We conducted a nonrandomized, single arm, multicenter investigation of the effect of HOPE using the XVIVO Heart Preservation System on donor hearts with a projected preservation time of 6 to 8 hours on 30-day recipient survival and allograft function post-transplant. Each center completed 1 or 2 short preservation time followed by long preservation time cases. PGD was classified as occurring in the first 24 hours after transplantation or secondary graft dysfunction (SGD) occurring at any time with a clearly defined cause. Trial survival was compared with a comparator group based on data from the International Society of Heart and Lung Transplantation (ISHLT) Registry.
RESULTS: We performed heart transplants using 7 short and 29 long preservation time donor hearts placed on the HOPE system. The mean preservation time for the long preservation time cases was 414 minutes, the longest being 8 hours and 47 minutes. There was 100% survival at 30 days. One long preservation time recipient developed PGD, and 1 developed SGD. One short preservation time patient developed SGD. Thirty day survival was superior to the ISHLT comparator group despite substantially longer preservation times in the trial patients.
CONCLUSIONS: HOPE provides effective preservation out to preservation times of nearly 9 hours allowing retrieval from remote geographic locations.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2024 |
|---|---|
| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:43 |
|---|---|
| Enthalten in: |
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation - 43(2024), 3 vom: 14. März, Seite 485-495 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
McGiffin, David C [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Clinical Trial |
|---|
| Anmerkungen: |
Date Completed 26.02.2024 Date Revised 08.03.2024 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1016/j.healun.2023.10.020 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM364105755 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM364105755 | ||
| 003 | DE-627 | ||
| 005 | 20240308232129.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.healun.2023.10.020 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1320.xml |
| 035 | |a (DE-627)NLM364105755 | ||
| 035 | |a (NLM)37918701 | ||
| 035 | |a (PII)S1053-2498(23)02110-1 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a McGiffin, David C |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Hypothermic oxygenated perfusion (HOPE) safely and effectively extends acceptable donor heart preservation times |b Results of the Australian and New Zealand trial |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 26.02.2024 | ||
| 500 | |a Date Revised 08.03.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2024 International Society for the Heart and Lung Transplantation. Published by Elsevier Inc. All rights reserved. | ||
| 520 | |a BACKGROUND: Cold static storage preservation of donor hearts for periods longer than 4 hours increases the risk of primary graft dysfunction (PGD). The aim of the study was to determine if hypothermic oxygenated perfusion (HOPE) could safely prolong the preservation time of donor hearts | ||
| 520 | |a METHODS: We conducted a nonrandomized, single arm, multicenter investigation of the effect of HOPE using the XVIVO Heart Preservation System on donor hearts with a projected preservation time of 6 to 8 hours on 30-day recipient survival and allograft function post-transplant. Each center completed 1 or 2 short preservation time followed by long preservation time cases. PGD was classified as occurring in the first 24 hours after transplantation or secondary graft dysfunction (SGD) occurring at any time with a clearly defined cause. Trial survival was compared with a comparator group based on data from the International Society of Heart and Lung Transplantation (ISHLT) Registry | ||
| 520 | |a RESULTS: We performed heart transplants using 7 short and 29 long preservation time donor hearts placed on the HOPE system. The mean preservation time for the long preservation time cases was 414 minutes, the longest being 8 hours and 47 minutes. There was 100% survival at 30 days. One long preservation time recipient developed PGD, and 1 developed SGD. One short preservation time patient developed SGD. Thirty day survival was superior to the ISHLT comparator group despite substantially longer preservation times in the trial patients | ||
| 520 | |a CONCLUSIONS: HOPE provides effective preservation out to preservation times of nearly 9 hours allowing retrieval from remote geographic locations | ||
| 650 | 4 | |a Clinical Trial | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Multicenter Study | |
| 650 | 4 | |a extended preservation time | |
| 650 | 4 | |a heart transplantation | |
| 650 | 4 | |a hypothermic machine perfusion | |
| 650 | 4 | |a organ preservation | |
| 650 | 4 | |a primary graft dysfunction | |
| 700 | 1 | |a Kure, Christina E |e verfasserin |4 aut | |
| 700 | 1 | |a Macdonald, Peter S |e verfasserin |4 aut | |
| 700 | 1 | |a Jansz, Paul C |e verfasserin |4 aut | |
| 700 | 1 | |a Emmanuel, Sam |e verfasserin |4 aut | |
| 700 | 1 | |a Marasco, Silvana F |e verfasserin |4 aut | |
| 700 | 1 | |a Doi, Atsuo |e verfasserin |4 aut | |
| 700 | 1 | |a Merry, Chris |e verfasserin |4 aut | |
| 700 | 1 | |a Larbalestier, Robert |e verfasserin |4 aut | |
| 700 | 1 | |a Shah, Amit |e verfasserin |4 aut | |
| 700 | 1 | |a Geldenhuys, Agneta |e verfasserin |4 aut | |
| 700 | 1 | |a Sibal, Amul K |e verfasserin |4 aut | |
| 700 | 1 | |a Wasywich, Cara A |e verfasserin |4 aut | |
| 700 | 1 | |a Mathew, Jacob |e verfasserin |4 aut | |
| 700 | 1 | |a Paul, Eldho |e verfasserin |4 aut | |
| 700 | 1 | |a Cheshire, Caitlin |e verfasserin |4 aut | |
| 700 | 1 | |a Leet, Angeline |e verfasserin |4 aut | |
| 700 | 1 | |a Hare, James L |e verfasserin |4 aut | |
| 700 | 1 | |a Graham, Sandra |e verfasserin |4 aut | |
| 700 | 1 | |a Fraser, John F |e verfasserin |4 aut | |
| 700 | 1 | |a Kaye, David M |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation |d 1993 |g 43(2024), 3 vom: 14. März, Seite 485-495 |w (DE-627)NLM012612367 |x 1557-3117 |7 nnns |
| 773 | 1 | 8 | |g volume:43 |g year:2024 |g number:3 |g day:14 |g month:03 |g pages:485-495 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.healun.2023.10.020 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 43 |j 2024 |e 3 |b 14 |c 03 |h 485-495 | ||