Plasma TNF-α and phosphorylated α-syn are associated with fatigue in patients with Parkinson's disease
Copyright © 2023. Published by Elsevier B.V..
BACKGROUD: Fatigue is one of the most common non-motor symptoms among patients with Parkinson's disease (PD).However, the pathogenesis keeps largely unknown. Moreover, it is lack of objective biomarker.
OBJECTIVE: To investigate the relationship between plasma inflammatory cytokines and α-syn levels and fatigue in patients with PD.
METHODS: A total of 63 PD patients were enrolled, including 35 patients with fatigue and 28 patients without fatigue. We compared the difference between plasma cytokines and alpha-synuclein (α-syn) in the two groups. Meanwhile, we analyzed the relationship between plasma cytokines and p-α-syn levels and fatigue.
RESULTS: PD patients with fatigue had older age, longer disease duration, more severe motor scores. There were significant differences in the plasma levels of IL-1β, IL-18, TNF-α, and phosphorylated α-syn (p-α-syn) between the two groups. The plasm inflammatory cytokine levels (IL-1β, IL-18 and TNF-α) were positively associated with FSS scores. Moreover, the plasma p-α-syn level was significantly positively correlated with FSS scores. Furthermore, the higher PDQ-39 scores and higher plasma levels of TNF-α and p-α-syn were strongly associated with fatigue in PD. The ROC curve analysis showed the AUC of TNF-α for fatigue in PD was 0.663 with a sensitivity of 65.71% and specificity of 67.86%, while the AUC of p-α-syn was 0.786 with a sensitivity of 74.29% and specificity of 64.29%. The combination of TNF-α and p-α-syn improves the AUC to 0.803 with a sensitivity of 88.57% and specificity of 64.29%.
CONCLUSION: The high plasma levels of TNF-α and p-α-syn were strongly associated with fatigue in PD.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2023 |
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Erschienen: |
2023 |
Enthalten in: |
Zur Gesamtaufnahme - volume:385 |
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Enthalten in: |
Journal of neuroimmunology - 385(2023) vom: 15. Dez., Seite 578222 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Wang, Lijun [VerfasserIn] |
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Links: |
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Anmerkungen: |
Date Completed 11.01.2024 Date Revised 18.01.2024 published: Print-Electronic Citation Status MEDLINE |
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doi: |
10.1016/j.jneuroim.2023.578222 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM364100915 |
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100 | 1 | |a Wang, Lijun |e verfasserin |4 aut | |
245 | 1 | 0 | |a Plasma TNF-α and phosphorylated α-syn are associated with fatigue in patients with Parkinson's disease |
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500 | |a published: Print-Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a Copyright © 2023. Published by Elsevier B.V. | ||
520 | |a BACKGROUD: Fatigue is one of the most common non-motor symptoms among patients with Parkinson's disease (PD).However, the pathogenesis keeps largely unknown. Moreover, it is lack of objective biomarker | ||
520 | |a OBJECTIVE: To investigate the relationship between plasma inflammatory cytokines and α-syn levels and fatigue in patients with PD | ||
520 | |a METHODS: A total of 63 PD patients were enrolled, including 35 patients with fatigue and 28 patients without fatigue. We compared the difference between plasma cytokines and alpha-synuclein (α-syn) in the two groups. Meanwhile, we analyzed the relationship between plasma cytokines and p-α-syn levels and fatigue | ||
520 | |a RESULTS: PD patients with fatigue had older age, longer disease duration, more severe motor scores. There were significant differences in the plasma levels of IL-1β, IL-18, TNF-α, and phosphorylated α-syn (p-α-syn) between the two groups. The plasm inflammatory cytokine levels (IL-1β, IL-18 and TNF-α) were positively associated with FSS scores. Moreover, the plasma p-α-syn level was significantly positively correlated with FSS scores. Furthermore, the higher PDQ-39 scores and higher plasma levels of TNF-α and p-α-syn were strongly associated with fatigue in PD. The ROC curve analysis showed the AUC of TNF-α for fatigue in PD was 0.663 with a sensitivity of 65.71% and specificity of 67.86%, while the AUC of p-α-syn was 0.786 with a sensitivity of 74.29% and specificity of 64.29%. The combination of TNF-α and p-α-syn improves the AUC to 0.803 with a sensitivity of 88.57% and specificity of 64.29% | ||
520 | |a CONCLUSION: The high plasma levels of TNF-α and p-α-syn were strongly associated with fatigue in PD | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Research Support, Non-U.S. Gov't | |
650 | 4 | |a Fatigue | |
650 | 4 | |a Inflammatory cytokines | |
650 | 4 | |a Parkinson's disease | |
650 | 4 | |a Phosphorylated α-synuclein | |
650 | 4 | |a TNF-α | |
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700 | 1 | |a Yi, Hongyan |e verfasserin |4 aut | |
700 | 1 | |a Liang, Xiaojing |e verfasserin |4 aut | |
700 | 1 | |a Xu, Fugui |e verfasserin |4 aut | |
700 | 1 | |a Li, Tiantian |e verfasserin |4 aut | |
700 | 1 | |a Yang, Xiu |e verfasserin |4 aut | |
700 | 1 | |a Wei, Ming |e verfasserin |4 aut | |
700 | 1 | |a Ou, Zhou |e verfasserin |4 aut | |
700 | 1 | |a Tong, Qiang |e verfasserin |4 aut | |
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