Qualitative MR features to identify non-enhancing tumors within glioblastoma's T2-FLAIR hyperintense lesions
© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature..
PURPOSE: To identify qualitative MRI features of non-(contrast)-enhancing tumor (nCET) in glioblastoma's T2-FLAIR hyperintense lesion.
METHODS: Thirty-three histologically confirmed glioblastoma patients whose T1-, T2- and contrast-enhanced T1-weighted MRI and 11C-methionine positron emission tomography (Met-PET) were available were included in this study. Met-PET was utilized as a surrogate for tumor burden. Imaging features for identifying nCET were searched by qualitative examination of 156 targets. A new scoring system to identify nCET was established and validated by two independent observers.
RESULTS: Three imaging features were found helpful for identifying nCET; "Bulky gray matter involvement", "Around the rim of contrast-enhancement (Around-rim)," and "High-intensity on T1WI and low-intensity on T2WI (HighT1LowT2)" resulting in an nCET score = 2 × Bulky gray matter involvement - 2 × Around-rim + HighT1LowT2 + 2. The nCET score's classification performances of two independent observers measured by AUC were 0.78 and 0.80, with sensitivities and specificities using a threshold of four being 0.443 and 0.771, and 0.916 and 0.768, respectively. The weighted kappa coefficient for the nCET score was 0.946.
CONCLUSION: The current investigation demonstrated that qualitative assessments of glioblastoma's MRI might help identify nCET in T2/FLAIR high-intensity lesions. The novel nCET score is expected to aid in expanding treatment targets within the T2/FLAIR high-intensity lesions.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:165 |
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| Enthalten in: |
Journal of neuro-oncology - 165(2023), 2 vom: 02. Nov., Seite 251-259 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Yamamoto, Shota [VerfasserIn] |
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AE28F7PNPL |
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| Anmerkungen: |
Date Completed 01.12.2023 Date Revised 01.12.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s11060-023-04454-9 |
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NLM364091622 |
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| 245 | 1 | 0 | |a Qualitative MR features to identify non-enhancing tumors within glioblastoma's T2-FLAIR hyperintense lesions |
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| 520 | |a © 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. | ||
| 520 | |a PURPOSE: To identify qualitative MRI features of non-(contrast)-enhancing tumor (nCET) in glioblastoma's T2-FLAIR hyperintense lesion | ||
| 520 | |a METHODS: Thirty-three histologically confirmed glioblastoma patients whose T1-, T2- and contrast-enhanced T1-weighted MRI and 11C-methionine positron emission tomography (Met-PET) were available were included in this study. Met-PET was utilized as a surrogate for tumor burden. Imaging features for identifying nCET were searched by qualitative examination of 156 targets. A new scoring system to identify nCET was established and validated by two independent observers | ||
| 520 | |a RESULTS: Three imaging features were found helpful for identifying nCET; "Bulky gray matter involvement", "Around the rim of contrast-enhancement (Around-rim)," and "High-intensity on T1WI and low-intensity on T2WI (HighT1LowT2)" resulting in an nCET score = 2 × Bulky gray matter involvement - 2 × Around-rim + HighT1LowT2 + 2. The nCET score's classification performances of two independent observers measured by AUC were 0.78 and 0.80, with sensitivities and specificities using a threshold of four being 0.443 and 0.771, and 0.916 and 0.768, respectively. The weighted kappa coefficient for the nCET score was 0.946 | ||
| 520 | |a CONCLUSION: The current investigation demonstrated that qualitative assessments of glioblastoma's MRI might help identify nCET in T2/FLAIR high-intensity lesions. The novel nCET score is expected to aid in expanding treatment targets within the T2/FLAIR high-intensity lesions | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Glioblastoma | |
| 650 | 4 | |a MRI | |
| 650 | 4 | |a Non-contrast-enhancing tumor | |
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| 700 | 1 | |a Sanada, Takahiro |e verfasserin |4 aut | |
| 700 | 1 | |a Sakai, Mio |e verfasserin |4 aut | |
| 700 | 1 | |a Arisawa, Atsuko |e verfasserin |4 aut | |
| 700 | 1 | |a Kagawa, Naoki |e verfasserin |4 aut | |
| 700 | 1 | |a Shimosegawa, Eku |e verfasserin |4 aut | |
| 700 | 1 | |a Nakanishi, Katsuyuki |e verfasserin |4 aut | |
| 700 | 1 | |a Kinoshita, Manabu |e verfasserin |4 aut | |
| 700 | 1 | |a Kishima, Haruhiko |e verfasserin |4 aut | |
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