Characterization of non-neutralizing human monoclonal antibodies that target the M1 and NP of influenza A viruses
IMPORTANCE: Currently, many groups are focusing on isolating both neutralizing and non-neutralizing antibodies to the mutation-prone hemagglutinin as a tool to treat or prevent influenza virus infection. Less is known about the level of protection induced by non-neutralizing antibodies that target conserved internal influenza virus proteins. Such non-neutralizing antibodies could provide an alternative pathway to induce broad cross-reactive protection against multiple influenza virus serotypes and subtypes by partially overcoming influenza virus escape mediated by antigenic drift and shift. Accordingly, more information about the level of protection and potential mechanism(s) of action of non-neutralizing antibodies targeting internal influenza virus proteins could be useful for the design of broadly protective and universal influenza virus vaccines.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:97 |
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| Enthalten in: |
Journal of virology - 97(2023), 11 vom: 30. Nov., Seite e0164622 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Rijnink, Willemijn Frederique [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 06.12.2023 Date Revised 30.01.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1128/jvi.01646-22 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM36408717X |
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| 100 | 1 | |a Rijnink, Willemijn Frederique |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Characterization of non-neutralizing human monoclonal antibodies that target the M1 and NP of influenza A viruses |
| 264 | 1 | |c 2023 | |
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| 500 | |a Date Completed 06.12.2023 | ||
| 500 | |a Date Revised 30.01.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a IMPORTANCE: Currently, many groups are focusing on isolating both neutralizing and non-neutralizing antibodies to the mutation-prone hemagglutinin as a tool to treat or prevent influenza virus infection. Less is known about the level of protection induced by non-neutralizing antibodies that target conserved internal influenza virus proteins. Such non-neutralizing antibodies could provide an alternative pathway to induce broad cross-reactive protection against multiple influenza virus serotypes and subtypes by partially overcoming influenza virus escape mediated by antigenic drift and shift. Accordingly, more information about the level of protection and potential mechanism(s) of action of non-neutralizing antibodies targeting internal influenza virus proteins could be useful for the design of broadly protective and universal influenza virus vaccines | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 7 | |a Antibodies, Monoclonal |2 NLM | |
| 650 | 7 | |a Antibodies, Viral |2 NLM | |
| 650 | 7 | |a Hemagglutinin Glycoproteins, Influenza Virus |2 NLM | |
| 650 | 7 | |a M1 protein, Influenza A virus |2 NLM | |
| 650 | 7 | |a NP protein, Influenza A virus |2 NLM | |
| 650 | 7 | |a Viral Matrix Proteins |2 NLM | |
| 650 | 7 | |a Nucleocapsid Proteins |2 NLM | |
| 700 | 1 | |a Stadlbauer, Daniel |e verfasserin |4 aut | |
| 700 | 1 | |a Puente-Massaguer, Eduard |e verfasserin |4 aut | |
| 700 | 1 | |a Okba, Nisreen M A |e verfasserin |4 aut | |
| 700 | 1 | |a Kirkpatrick Roubidoux, Ericka |e verfasserin |4 aut | |
| 700 | 1 | |a Strohmeier, Shirin |e verfasserin |4 aut | |
| 700 | 1 | |a Mudd, Philip A |e verfasserin |4 aut | |
| 700 | 1 | |a Schmitz, Aaron |e verfasserin |4 aut | |
| 700 | 1 | |a Ellebedy, Ali |e verfasserin |4 aut | |
| 700 | 1 | |a McMahon, Meagan |e verfasserin |4 aut | |
| 700 | 1 | |a Krammer, Florian |e verfasserin |4 aut | |
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