Intravenous Iron for Heart Failure : Updated Systematic Review and Meta-Analysis
While the administration of intravenous (IV) iron to those with heart failure has been implicated to be associated with a possible reduction in hospitalizations and improvement in symptoms, a recent large multicenter trial only showed modest benefits in reducing hospitalization, necessitating the updated systematic review. We conducted a systematic review and meta-analysis, searching the MEDLINE and EMBASE database until January 9, 2023. Outcomes included total heart failure hospitalizations, first heart failure hospitalization, six-minute walk test (6MWT) distance, and incidence of infection. There were 13 studies with 3410 participants (1,790 with IV iron). Pooled analysis that reported the incidence of cardiovascular death showed that patients with IV iron did not have significantly lower odds of cardiovascular death or first heart failure hospitalization. In contrast, those who received IV iron had significantly lower total heart failure hospitalization (pooled odds ratio (OR) 0.63, 95% confidence interval (CI) 0.44-0.90, I2 59.0%, P = .017) and a composite of cardiovascular death and first heart failure hospitalization (pooled OR 0.55, 95% CI 0.47-0.64, I2 0%, P = .656). While the efficacy is modest, IV iron therapy could be associated with reduced hospitalization for heart failure without significant adverse events.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2023 |
---|---|
Erschienen: |
2023 |
Enthalten in: |
Zur Gesamtaufnahme - year:2023 |
---|---|
Enthalten in: |
Angiology - (2023) vom: 02. Nov., Seite 33197231213181 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Techasatian, Witina [VerfasserIn] |
---|
Links: |
---|
Themen: |
Heart failure |
---|
Anmerkungen: |
Date Revised 02.11.2023 published: Print-Electronic Citation Status Publisher |
---|
doi: |
10.1177/00033197231213181 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM36408314X |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM36408314X | ||
003 | DE-627 | ||
005 | 20231226094710.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231226s2023 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1177/00033197231213181 |2 doi | |
028 | 5 | 2 | |a pubmed24n1213.xml |
035 | |a (DE-627)NLM36408314X | ||
035 | |a (NLM)37916421 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Techasatian, Witina |e verfasserin |4 aut | |
245 | 1 | 0 | |a Intravenous Iron for Heart Failure |b Updated Systematic Review and Meta-Analysis |
264 | 1 | |c 2023 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Revised 02.11.2023 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status Publisher | ||
520 | |a While the administration of intravenous (IV) iron to those with heart failure has been implicated to be associated with a possible reduction in hospitalizations and improvement in symptoms, a recent large multicenter trial only showed modest benefits in reducing hospitalization, necessitating the updated systematic review. We conducted a systematic review and meta-analysis, searching the MEDLINE and EMBASE database until January 9, 2023. Outcomes included total heart failure hospitalizations, first heart failure hospitalization, six-minute walk test (6MWT) distance, and incidence of infection. There were 13 studies with 3410 participants (1,790 with IV iron). Pooled analysis that reported the incidence of cardiovascular death showed that patients with IV iron did not have significantly lower odds of cardiovascular death or first heart failure hospitalization. In contrast, those who received IV iron had significantly lower total heart failure hospitalization (pooled odds ratio (OR) 0.63, 95% confidence interval (CI) 0.44-0.90, I2 59.0%, P = .017) and a composite of cardiovascular death and first heart failure hospitalization (pooled OR 0.55, 95% CI 0.47-0.64, I2 0%, P = .656). While the efficacy is modest, IV iron therapy could be associated with reduced hospitalization for heart failure without significant adverse events | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a heart failure | |
650 | 4 | |a intravenous iron | |
650 | 4 | |a systematic review | |
700 | 1 | |a Nishimura, Yoshito |e verfasserin |4 aut | |
700 | 1 | |a Tanariyakul, Manasawee |e verfasserin |4 aut | |
700 | 1 | |a Morihara, Clarke |e verfasserin |4 aut | |
700 | 1 | |a Arayangkool, Chinnawat |e verfasserin |4 aut | |
700 | 1 | |a Settle, Alexander |e verfasserin |4 aut | |
700 | 1 | |a Aiumtrakul, Noppawit |e verfasserin |4 aut | |
700 | 1 | |a Kewcharoen, Jakrin |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Angiology |d 1950 |g (2023) vom: 02. Nov., Seite 33197231213181 |w (DE-627)NLM000181846 |x 1940-1574 |7 nnns |
773 | 1 | 8 | |g year:2023 |g day:02 |g month:11 |g pages:33197231213181 |
856 | 4 | 0 | |u http://dx.doi.org/10.1177/00033197231213181 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |j 2023 |b 02 |c 11 |h 33197231213181 |