Research progress on the correlation between transforming growth factor-β level and symptoms of depression
Transforming growth factor (TGF)-β is a group of cytokines with anti-inflammatory effects in the TGF family, which participates in the development of stress and depression-related mechanisms, and plays roles in the regulation of inflammatory response in depression and the recovery of various cytokine imbalances. The core symptoms of depression is associated with TGF-β level, and the psychological symptoms of depression are related to TGF-β gene polymorphism. Various antidepressants may up-regulate TGF-β level through the complex interaction between neurotransmitters and inflammatory factors, inhibiting inflammatory response and regulating cytokine imbalance to improve depressive symptoms. Studies have shown that recombinant TGF-β1 protein has beneficial effects in mouse depression models, indicating TGF-β1 might be a potential therapeutic target for depression and nasal sprays having the advantage of being fast acting delivery method. This article reviews the research progress on dynamic changes of TGF-β level before and after depression treatment and the application of TGF-β level as an indicator for the improvement of depressive symptoms. We provide ideas for the development of new antidepressants and for the evaluation of the treatment efficacy in depression.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:52 |
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| Enthalten in: |
Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences - 52(2023), 5 vom: 25. Sept., Seite 646-652 |
| Sprache: |
Englisch |
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| Weiterer Titel: |
转化生长因子-β水平与抑郁症疗效相关 |
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| Beteiligte Personen: |
Li, Yanran [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 03.11.2023 Date Revised 10.11.2023 published: Electronic Citation Status MEDLINE |
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| doi: |
10.3724/zdxbyxb-2023-0269 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM364082046 |
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| 246 | 3 | 3 | |a 转化生长因子-β水平与抑郁症疗效相关 |
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| 520 | |a Transforming growth factor (TGF)-β is a group of cytokines with anti-inflammatory effects in the TGF family, which participates in the development of stress and depression-related mechanisms, and plays roles in the regulation of inflammatory response in depression and the recovery of various cytokine imbalances. The core symptoms of depression is associated with TGF-β level, and the psychological symptoms of depression are related to TGF-β gene polymorphism. Various antidepressants may up-regulate TGF-β level through the complex interaction between neurotransmitters and inflammatory factors, inhibiting inflammatory response and regulating cytokine imbalance to improve depressive symptoms. Studies have shown that recombinant TGF-β1 protein has beneficial effects in mouse depression models, indicating TGF-β1 might be a potential therapeutic target for depression and nasal sprays having the advantage of being fast acting delivery method. This article reviews the research progress on dynamic changes of TGF-β level before and after depression treatment and the application of TGF-β level as an indicator for the improvement of depressive symptoms. We provide ideas for the development of new antidepressants and for the evaluation of the treatment efficacy in depression | ||
| 650 | 4 | |a Review | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Depression | |
| 650 | 4 | |a Efficacy | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Target | |
| 650 | 4 | |a Transforming growth factor-β | |
| 650 | 7 | |a Transforming Growth Factor beta |2 NLM | |
| 650 | 7 | |a Transforming Growth Factor beta1 |2 NLM | |
| 650 | 7 | |a Cytokines |2 NLM | |
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| 700 | 1 | |a Wang, Huiying |e verfasserin |4 aut | |
| 700 | 1 | |a Zhou, Jiansong |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Changhong |e verfasserin |4 aut | |
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