Perinatal Outcome in Congenital Diaphragmatic Hernia (CDH) : A Single-Center Experience
© Federation of Obstetric & Gynecological Societies of India 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law..
Objective: To study the perinatal outcome in fetuses diagnosed with congenital diaphragmatic hernia (CDH).
Methods: Thirty-two pregnant women with antenatal diagnosis of CDH in fetus, who delivered between 2018 and 2021, were included in the study. Postnatally eventration of diaphragm was diagnosed in 3 neonates and were excluded.
Results: The median gestational age at diagnosis was 23 weeks (IQR: 216-261 weeks). The mean O/E LHR was 34.88 ± 9.03%, and the O/E LHR was significantly lower in fetuses who did not survive (40.81 ± 4.25 vs 31.26 ± 9.33; p = 0.0037). On ROC analysis, at a cutoff of ≤ 32.93, O/E LHR had a specificity of 100% with a sensitivity of 72.22% in predicting mortality. Cases with liver herniation were not significantly different between survivors versus non-survivors. The overall survival rate was 37.93%, and the leading cause of death was severe persistent pulmonary hypertension.
Conclusion: O/E LHR can predict mortality in neonates with antenatal diagnosis of CDH. The presence of pulmonary hypertension was the leading cause of death in these neonates.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:73 |
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| Enthalten in: |
Journal of obstetrics and gynaecology of India - 73(2023), Suppl 1 vom: 24. Okt., Seite 37-42 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Rana, Anubhuti [VerfasserIn] |
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| Links: |
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| Themen: |
Congenital diaphragmatic hernia |
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| Anmerkungen: |
Date Revised 03.11.2023 published: Print-Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1007/s13224-023-01796-2 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a © Federation of Obstetric & Gynecological Societies of India 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. | ||
| 520 | |a Objective: To study the perinatal outcome in fetuses diagnosed with congenital diaphragmatic hernia (CDH) | ||
| 520 | |a Methods: Thirty-two pregnant women with antenatal diagnosis of CDH in fetus, who delivered between 2018 and 2021, were included in the study. Postnatally eventration of diaphragm was diagnosed in 3 neonates and were excluded | ||
| 520 | |a Results: The median gestational age at diagnosis was 23 weeks (IQR: 216-261 weeks). The mean O/E LHR was 34.88 ± 9.03%, and the O/E LHR was significantly lower in fetuses who did not survive (40.81 ± 4.25 vs 31.26 ± 9.33; p = 0.0037). On ROC analysis, at a cutoff of ≤ 32.93, O/E LHR had a specificity of 100% with a sensitivity of 72.22% in predicting mortality. Cases with liver herniation were not significantly different between survivors versus non-survivors. The overall survival rate was 37.93%, and the leading cause of death was severe persistent pulmonary hypertension | ||
| 520 | |a Conclusion: O/E LHR can predict mortality in neonates with antenatal diagnosis of CDH. The presence of pulmonary hypertension was the leading cause of death in these neonates | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Congenital diaphragmatic hernia | |
| 650 | 4 | |a O/E LHR | |
| 650 | 4 | |a Perinatal outcome | |
| 650 | 4 | |a Pulmonary hypertension | |
| 700 | 1 | |a Sharma, K Aparna |e verfasserin |4 aut | |
| 700 | 1 | |a Kumar, Vivek |e verfasserin |4 aut | |
| 700 | 1 | |a Chaudhary, Priyanka |e verfasserin |4 aut | |
| 700 | 1 | |a Thukral, Anu |e verfasserin |4 aut | |
| 700 | 1 | |a Agarwala, Sandeep |e verfasserin |4 aut | |
| 700 | 1 | |a Dadhwal, Vatsla |e verfasserin |4 aut | |
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