Effects of intracerebroventricular administration of calcitonin gene-related peptide (CGRP) on sex hormones and sperm quality in rats
Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc..
Background: Therapeutic strategies with calcitonin gene-related peptide (CGRP) or its receptor have been investigated, but there are few studies regarding the possible harmful effects of CGRP in other body organs.
Objective: This study aimed to investigate the effect of intracerebroventricular (ICV) injection of CGRP on sex hormones and sperm quality in rats.
Methods: Twelve male rats were divided into two groups (n=6 per group). The first group (control) rats were injected with 5 µl artificial cerebrospinal fluid intra-ICV; the second group rats, 5 µl (1.5 nmol) CGRP. The levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), and testosterone were measured. Epididymal sperms were used to determine the sperm parameters.
Results: The levels of testosterone, LH and FSH in CGRP group was significantly lower than in artificial cerebrospinal fluid (ACSF) group (P<0.05). The concentration and motility of sperm in CGRP group was significantly lower than in ACSF group (P<0.05). In CGRP group live spermatozoa and intact acrosome significantly reduced compared to the ACSF group (P<0.05). In addition, in CGRP group dead spermatozoa and lose acrosome significantly increased compared to the ACSF group (P<0.05).
Conclusion: ICV injection of CGRP may reduce sperm quality, probably through induction of an imbalance in FSH and LH production as well as testosterone.
| Errataetall: |
CommentIn: Ann Med Surg (Lond). 2024 Mar 06;86(3):1821. - PMID 38463055 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:85 |
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| Enthalten in: |
Annals of medicine and surgery (2012) - 85(2023), 11 vom: 01. Nov., Seite 5454-5458 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Rahimi, Kaveh [VerfasserIn] |
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| Links: |
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| Themen: |
CGRP |
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| Anmerkungen: |
Date Revised 11.03.2024 published: Electronic-eCollection CommentIn: Ann Med Surg (Lond). 2024 Mar 06;86(3):1821. - PMID 38463055 Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1097/MS9.0000000000001252 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM364075546 |
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| 245 | 1 | 0 | |a Effects of intracerebroventricular administration of calcitonin gene-related peptide (CGRP) on sex hormones and sperm quality in rats |
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| 500 | |a Date Revised 11.03.2024 | ||
| 500 | |a published: Electronic-eCollection | ||
| 500 | |a CommentIn: Ann Med Surg (Lond). 2024 Mar 06;86(3):1821. - PMID 38463055 | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. | ||
| 520 | |a Background: Therapeutic strategies with calcitonin gene-related peptide (CGRP) or its receptor have been investigated, but there are few studies regarding the possible harmful effects of CGRP in other body organs | ||
| 520 | |a Objective: This study aimed to investigate the effect of intracerebroventricular (ICV) injection of CGRP on sex hormones and sperm quality in rats | ||
| 520 | |a Methods: Twelve male rats were divided into two groups (n=6 per group). The first group (control) rats were injected with 5 µl artificial cerebrospinal fluid intra-ICV; the second group rats, 5 µl (1.5 nmol) CGRP. The levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), and testosterone were measured. Epididymal sperms were used to determine the sperm parameters | ||
| 520 | |a Results: The levels of testosterone, LH and FSH in CGRP group was significantly lower than in artificial cerebrospinal fluid (ACSF) group (P<0.05). The concentration and motility of sperm in CGRP group was significantly lower than in ACSF group (P<0.05). In CGRP group live spermatozoa and intact acrosome significantly reduced compared to the ACSF group (P<0.05). In addition, in CGRP group dead spermatozoa and lose acrosome significantly increased compared to the ACSF group (P<0.05) | ||
| 520 | |a Conclusion: ICV injection of CGRP may reduce sperm quality, probably through induction of an imbalance in FSH and LH production as well as testosterone | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a CGRP | |
| 650 | 4 | |a FSH | |
| 650 | 4 | |a Intracerebroventricular injection | |
| 650 | 4 | |a LH | |
| 650 | 4 | |a Testosterone | |
| 700 | 1 | |a Riyahi, Moslem |e verfasserin |4 aut | |
| 700 | 1 | |a Sajedianfard, Javad |e verfasserin |4 aut | |
| 700 | 1 | |a Nazifi, Saeed |e verfasserin |4 aut | |
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