Molecular prevalence of Pneumocystis jirovecii and Cryptosporidium in patients with asthma
Copyright © 2023 Elsevier Inc. All rights reserved..
Asthma is characterized by chronic airway inflammation. In addition to allergens, microorganisms can affect the clinical course of asthma. It has been shown that some fungi play an important role in the progression of asthma. However, the effects of Pneumocystis jirovecii and Cryptosporidium spp., on the disease are little known. We investigated P. jirovecii and Cryptosporidium spp. in the sputum and stool sample of patients with asthma (n = 40) by microscopy and PCR compared to the healthy group (n = 40). P. jirovecii (12.5 %), and Cryptosporidium spp. (12.5 %) were detected in the sputum samples of only asthmatic patients (p = 0.029 and 0.029 respectively). However, Crpytosporidium spp. was detected equally in stool samples of both groups (p = 0.682). Our results indicate that P. jirovecii and Cryptosporidium spp. should be considered in patients with asthma and molecular screening of these neglected eukaryotes in respiratory tract samples may be beneficial in the clinical management of the disease.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 2023 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:108 |
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| Enthalten in: |
Diagnostic microbiology and infectious disease - 108(2023), 1 vom: 21. Jan., Seite 116124 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ulusan Bagci, Ozlem [VerfasserIn] |
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| Links: |
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| Themen: |
Asthma |
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| Anmerkungen: |
Date Completed 16.12.2023 Date Revised 16.12.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.diagmicrobio.2023.116124 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM36405591X |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2023 Elsevier Inc. All rights reserved. | ||
| 520 | |a Asthma is characterized by chronic airway inflammation. In addition to allergens, microorganisms can affect the clinical course of asthma. It has been shown that some fungi play an important role in the progression of asthma. However, the effects of Pneumocystis jirovecii and Cryptosporidium spp., on the disease are little known. We investigated P. jirovecii and Cryptosporidium spp. in the sputum and stool sample of patients with asthma (n = 40) by microscopy and PCR compared to the healthy group (n = 40). P. jirovecii (12.5 %), and Cryptosporidium spp. (12.5 %) were detected in the sputum samples of only asthmatic patients (p = 0.029 and 0.029 respectively). However, Crpytosporidium spp. was detected equally in stool samples of both groups (p = 0.682). Our results indicate that P. jirovecii and Cryptosporidium spp. should be considered in patients with asthma and molecular screening of these neglected eukaryotes in respiratory tract samples may be beneficial in the clinical management of the disease | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Asthma | |
| 650 | 4 | |a Cryptosporidium | |
| 650 | 4 | |a Pneumocystis jirovecii | |
| 650 | 4 | |a Sputum | |
| 650 | 4 | |a Stool | |
| 700 | 1 | |a Goksel, Ozlem |e verfasserin |4 aut | |
| 700 | 1 | |a Gumusburun, Reyhan |e verfasserin |4 aut | |
| 700 | 1 | |a Mert, Ufuk |e verfasserin |4 aut | |
| 700 | 1 | |a Bogatekin, Gulhan |e verfasserin |4 aut | |
| 700 | 1 | |a Toz, Seray |e verfasserin |4 aut | |
| 700 | 1 | |a Caner, Ayse |e verfasserin |4 aut | |
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