Diverging humoral and cellular immune responses due to Omicron-a national study from the Faroe Islands
IMPORTANCE: The immunity following infection and vaccination with the SARS-CoV-2 Omicron variant is poorly understood. We investigated immunity assessed with antibody and T-cell responses under different scenarios in vaccinated and unvaccinated individuals with and without Omicron infection. We found that the humoral response was higher among vaccinated-naïve than unvaccinated convalescent. Unvaccinated with and without infection had comparable low humoral responses, whereas vaccinated with a second or third dose, independent of infection status, had increasingly higher levels. Only a minor fraction of unvaccinated individuals had detectable humoral responses following Omicron infection, while almost all had positive T-cell responses. In conclusion, primary Omicron infection mounts a low humoral immune response, enhanced by prior vaccination. Omicron infection induced a robust T-cell response in both unvaccinated and vaccinated, demonstrating that immune evasion of primary Omicron infection affects humoral immunity more than T-cell immunity.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:11 |
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| Enthalten in: |
Microbiology spectrum - 11(2023), 6 vom: 12. Dez., Seite e0086523 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Petersen, Maria Skaalum [VerfasserIn] |
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| Links: |
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| Themen: |
Antibodies, Neutralizing |
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| Anmerkungen: |
Date Completed 16.12.2023 Date Revised 16.12.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1128/spectrum.00865-23 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM364016779 |
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| 245 | 1 | 0 | |a Diverging humoral and cellular immune responses due to Omicron-a national study from the Faroe Islands |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a IMPORTANCE: The immunity following infection and vaccination with the SARS-CoV-2 Omicron variant is poorly understood. We investigated immunity assessed with antibody and T-cell responses under different scenarios in vaccinated and unvaccinated individuals with and without Omicron infection. We found that the humoral response was higher among vaccinated-naïve than unvaccinated convalescent. Unvaccinated with and without infection had comparable low humoral responses, whereas vaccinated with a second or third dose, independent of infection status, had increasingly higher levels. Only a minor fraction of unvaccinated individuals had detectable humoral responses following Omicron infection, while almost all had positive T-cell responses. In conclusion, primary Omicron infection mounts a low humoral immune response, enhanced by prior vaccination. Omicron infection induced a robust T-cell response in both unvaccinated and vaccinated, demonstrating that immune evasion of primary Omicron infection affects humoral immunity more than T-cell immunity | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a Omicron | |
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| 650 | 4 | |a humoral immune response | |
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| 700 | 1 | |a Pérez-Alós, Laura |e verfasserin |4 aut | |
| 700 | 1 | |a Í Kongsstovu, Sunnvør K |e verfasserin |4 aut | |
| 700 | 1 | |a Eliasen, Eina Hansen |e verfasserin |4 aut | |
| 700 | 1 | |a Hansen, Cecilie Bo |e verfasserin |4 aut | |
| 700 | 1 | |a Larsen, Sólrun |e verfasserin |4 aut | |
| 700 | 1 | |a Hansen, Jóhanna Ljósá |e verfasserin |4 aut | |
| 700 | 1 | |a Bayarri-Olmos, Rafael |e verfasserin |4 aut | |
| 700 | 1 | |a Fjallsbak, Jógvan Páll |e verfasserin |4 aut | |
| 700 | 1 | |a Weihe, Pál |e verfasserin |4 aut | |
| 700 | 1 | |a Garred, Peter |e verfasserin |4 aut | |
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