Effect of lanthanum nitrate on adipogenesis in mice
© 2023 John Wiley & Sons, Ltd..
Lanthanum (La) is widely used in modern industry and agriculture because of its unique physicochemical properties and is broadly exposed in the population. Some studies have shown that La may have some effects on adipogenesis, but there is a lack of related in vivo evidence. In this study, the effects of La(NO3 )3 on adipogenesis and its associated mechanism were studied using C57BL/6J mouse model. The results showed that La(NO3 )3 exposure caused a decrease in body weight and the percentage of fat content in mice. In addition, the adipose marker molecules and specific adipogenic transcription factors decreased in both white adipose tissue (WAT) and brown adipose tissue (BAT). Detection of signaling pathway-related molecules revealed that canonical wnt/β-catenin pathway-related molecules were upregulated in both adipose tissues. In summary, in vivo exposure to La(NO3 )3 might inhibited adipogenesis in mice, possibly through upregulation of the canonical Wnt/β-catenin signaling pathway.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:44 |
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| Enthalten in: |
Journal of applied toxicology : JAT - 44(2024), 4 vom: 01. März, Seite 542-552 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ma, Yuhong [VerfasserIn] |
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| Links: |
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| Themen: |
33A856C3T7 |
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| Anmerkungen: |
Date Completed 19.03.2024 Date Revised 19.03.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1002/jat.4558 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM364000805 |
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| 520 | |a Lanthanum (La) is widely used in modern industry and agriculture because of its unique physicochemical properties and is broadly exposed in the population. Some studies have shown that La may have some effects on adipogenesis, but there is a lack of related in vivo evidence. In this study, the effects of La(NO3 )3 on adipogenesis and its associated mechanism were studied using C57BL/6J mouse model. The results showed that La(NO3 )3 exposure caused a decrease in body weight and the percentage of fat content in mice. In addition, the adipose marker molecules and specific adipogenic transcription factors decreased in both white adipose tissue (WAT) and brown adipose tissue (BAT). Detection of signaling pathway-related molecules revealed that canonical wnt/β-catenin pathway-related molecules were upregulated in both adipose tissues. In summary, in vivo exposure to La(NO3 )3 might inhibited adipogenesis in mice, possibly through upregulation of the canonical Wnt/β-catenin signaling pathway | ||
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| 700 | 1 | |a Zhao, Zhe |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Xiaoxia |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Qianyi |e verfasserin |4 aut | |
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| 700 | 1 | |a Wei, Xuetao |e verfasserin |4 aut | |
| 700 | 1 | |a Hao, Weidong |e verfasserin |4 aut | |
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