Plaque histological characteristics in individuals with sudden coronary death
Copyright © 2023 Elsevier Inc. All rights reserved..
Coronary artery disease (CAD) remains the leading cause of death in the Western world in individuals >20 years of age. CAD is the most common substrate underlying sudden cardiac death (SCD) in the Western world, being responsible for 50-75% of SCDs. In individuals dying suddenly with coronary thrombosis, plaque rupture occurs in 65%, plaque erosion in 30% and calcified nodule in 5%. We evaluated the extent of calcification in radiographs of hearts from patients dying of SCD and showed that calcification is absent in nearly 50% of erosion cases whereas only 10% of plaque rupture show no calcification. Conversely, stable plaques with >75% cross-sectional area luminal narrowing show the severest calcification (moderate to severe) in nearly 50% of cases. Identifying individuals who are susceptible to atherosclerosis may help reduce the incidence of SCD. The identification of coronary calcifications by noninvasive tools, however, only captures a fraction of complicating coronary lesions.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:153 |
|---|---|
| Enthalten in: |
Vascular pharmacology - 153(2023) vom: 15. Dez., Seite 107240 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Konishi, Takao [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Atherosclerosis |
|---|
| Anmerkungen: |
Date Completed 16.12.2023 Date Revised 16.12.2023 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1016/j.vph.2023.107240 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM363903925 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM363903925 | ||
| 003 | DE-627 | ||
| 005 | 20231227133127.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.vph.2023.107240 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1230.xml |
| 035 | |a (DE-627)NLM363903925 | ||
| 035 | |a (NLM)37898379 | ||
| 035 | |a (PII)S1537-1891(23)00100-3 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Konishi, Takao |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Plaque histological characteristics in individuals with sudden coronary death |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 16.12.2023 | ||
| 500 | |a Date Revised 16.12.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2023 Elsevier Inc. All rights reserved. | ||
| 520 | |a Coronary artery disease (CAD) remains the leading cause of death in the Western world in individuals >20 years of age. CAD is the most common substrate underlying sudden cardiac death (SCD) in the Western world, being responsible for 50-75% of SCDs. In individuals dying suddenly with coronary thrombosis, plaque rupture occurs in 65%, plaque erosion in 30% and calcified nodule in 5%. We evaluated the extent of calcification in radiographs of hearts from patients dying of SCD and showed that calcification is absent in nearly 50% of erosion cases whereas only 10% of plaque rupture show no calcification. Conversely, stable plaques with >75% cross-sectional area luminal narrowing show the severest calcification (moderate to severe) in nearly 50% of cases. Identifying individuals who are susceptible to atherosclerosis may help reduce the incidence of SCD. The identification of coronary calcifications by noninvasive tools, however, only captures a fraction of complicating coronary lesions | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Atherosclerosis | |
| 650 | 4 | |a Calcification | |
| 650 | 4 | |a Calcified nodule | |
| 650 | 4 | |a Erosion | |
| 650 | 4 | |a Inflammation | |
| 650 | 4 | |a Rupture | |
| 700 | 1 | |a Virmani, Renu |e verfasserin |4 aut | |
| 700 | 1 | |a Jinnouchi, Hiroyuki |e verfasserin |4 aut | |
| 700 | 1 | |a Kawai, Kenji |e verfasserin |4 aut | |
| 700 | 1 | |a Sekimoto, Teruo |e verfasserin |4 aut | |
| 700 | 1 | |a Kawakami, Rika |e verfasserin |4 aut | |
| 700 | 1 | |a Finn, Aloke V |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Vascular pharmacology |d 2002 |g 153(2023) vom: 15. Dez., Seite 107240 |w (DE-627)NLM121678628 |x 1879-3649 |7 nnns |
| 773 | 1 | 8 | |g volume:153 |g year:2023 |g day:15 |g month:12 |g pages:107240 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.vph.2023.107240 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 153 |j 2023 |b 15 |c 12 |h 107240 | ||