Comparing Three Profoundly Influential Prognostic Scores in Cirrhotic Patients with Acute-on-Chronic-Liver Failure Admitted to the ICU : Prediction of One-Month Mortality-A Retrospective Cohort Study
BACKGROUND: Acute-on-chronic-liver failure (ACLF) demonstrates high short-term mortality rates and usually requires intensive care unit (ICU) admission. Accurate prognostication of these patients is pivotal for timely referral for liver transplantation. The superiority of CLIF-C ACLF, CLIF-C ACLF lactate, and NACSELD-ACLF scores in Asian patients with ACLF admitted to an ICU remains inconclusive.
AIMS: To compare the predictive performance of CLIF-C ACLF, CLIF-C ACLF lactate, and NACSELD-ACLF scores for one-month mortality.
METHODS: 276 consecutive cirrhotic patients with ACLF admitted to ICU were enrolled. The prognostic values for one-month mortality were assessed by AUROC analysis.
RESULTS: The primary cause of cirrhosis in this cohort was alcohol abuse (56.5%). AUROC analysis (95% confidence intervals) demonstrated that CLIF-C ACLF lactate [0.802 (0.747-0.856)] outperformed both CLIF-C ACLF [0.791 (0.733-0.848)] and NACSELD-ACLF [0.673 (0.606-0.740)] in predicting one-month mortality. However, no statistically significant difference was observed between the predictive abilities of CLIF-C ACLF and CLIF-C ACLF lactate.
CONCLUSIONS: In critically ill cirrhotic patients with ACLF admitted to the hepatology ICU, CLIF ACLF-lactate outperformed CLIF-C ACLF and NACSELD-ACLF in predicting one-month mortality. Nevertheless, no statistically significant difference was observed between CLIF-C ACLF and CLIF-C ACLF lactate. Larger-scale multi-center prospective studies are warranted to validate these results.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:13 |
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| Enthalten in: |
Diagnostics (Basel, Switzerland) - 13(2023), 20 vom: 10. Okt. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Lin, Shih-Hua [VerfasserIn] |
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| Links: |
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| Themen: |
Acute-on-chronic liver failure (ACLF) |
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| Anmerkungen: |
Date Revised 30.10.2023 published: Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.3390/diagnostics13203160 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM363839984 |
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| 100 | 1 | |a Lin, Shih-Hua |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Comparing Three Profoundly Influential Prognostic Scores in Cirrhotic Patients with Acute-on-Chronic-Liver Failure Admitted to the ICU |b Prediction of One-Month Mortality-A Retrospective Cohort Study |
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| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a BACKGROUND: Acute-on-chronic-liver failure (ACLF) demonstrates high short-term mortality rates and usually requires intensive care unit (ICU) admission. Accurate prognostication of these patients is pivotal for timely referral for liver transplantation. The superiority of CLIF-C ACLF, CLIF-C ACLF lactate, and NACSELD-ACLF scores in Asian patients with ACLF admitted to an ICU remains inconclusive | ||
| 520 | |a AIMS: To compare the predictive performance of CLIF-C ACLF, CLIF-C ACLF lactate, and NACSELD-ACLF scores for one-month mortality | ||
| 520 | |a METHODS: 276 consecutive cirrhotic patients with ACLF admitted to ICU were enrolled. The prognostic values for one-month mortality were assessed by AUROC analysis | ||
| 520 | |a RESULTS: The primary cause of cirrhosis in this cohort was alcohol abuse (56.5%). AUROC analysis (95% confidence intervals) demonstrated that CLIF-C ACLF lactate [0.802 (0.747-0.856)] outperformed both CLIF-C ACLF [0.791 (0.733-0.848)] and NACSELD-ACLF [0.673 (0.606-0.740)] in predicting one-month mortality. However, no statistically significant difference was observed between the predictive abilities of CLIF-C ACLF and CLIF-C ACLF lactate | ||
| 520 | |a CONCLUSIONS: In critically ill cirrhotic patients with ACLF admitted to the hepatology ICU, CLIF ACLF-lactate outperformed CLIF-C ACLF and NACSELD-ACLF in predicting one-month mortality. Nevertheless, no statistically significant difference was observed between CLIF-C ACLF and CLIF-C ACLF lactate. Larger-scale multi-center prospective studies are warranted to validate these results | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a CLIF ACLF-lactate | |
| 650 | 4 | |a CLIF-C ACLF | |
| 650 | 4 | |a NACSELD ACLF | |
| 650 | 4 | |a acute-on-chronic liver failure (ACLF) | |
| 650 | 4 | |a specialized liver intensive care unit | |
| 700 | 1 | |a Chen, Wei-Ting |e verfasserin |4 aut | |
| 700 | 1 | |a Tsai, Ming-Hung |e verfasserin |4 aut | |
| 700 | 1 | |a Kuo, Wei-Liang |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Sheng-Fu |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Yu |e verfasserin |4 aut | |
| 700 | 1 | |a Chiu, Yu-Ting |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Bo-Huan |e verfasserin |4 aut | |
| 700 | 1 | |a Huang, Chien-Hao |e verfasserin |4 aut | |
| 700 | 1 | |a Chien, Rong-Nan |e verfasserin |4 aut | |
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