Development and Application of Prototype System Based on Light-Emitting Diode Arrays (660 nm) with a Top Hat Beam Profile in Order to Optimize Photobiomodulation Protocols for Treatment of Radiation-Induced Oral Mucositis in Rats
Background: Oral mucositis (OM) is a common adverse effect of radiation to the head and neck. Recent research has shown that extra oral photobiomodulation (EO-PBM) reduces the severity of OM. However, appropriate EO-PBM therapy parameters for OM severity reduction have not been documented. Objective: This work aims to optimize EO-PBM radiation parameters for lowering the severity of radiation-induced OM in rats by establishing a photobiomodulation (PBM) treatment system based on light-emitting diode arrays with top-hat beam profile. Methods: The 36 rats are separated into 2 control groups and 4 groups receiving PBM treatment. The PBM groups are exposed to irradiance between 4 and 24 J/cm2 at 660 nm. The cheek pouch mucosa is removed after scarification for biochemical and histological examination. Student's t-test, and one-way analysis of variance (ANOVA) followed by Tukey's Multiple were applied to compare the statistical significance of differences between control groups and PBM treatment groups. Results: Statistical analysis reveals that PBM irradiation at 12 J/cm2 (200 sec) with a flatness of 0.8 and a diameter of 3 cm substantially decreased the level of inflammatory cytokines compared with the positive control group. Conclusions: Our results indicate that the designed treatment PBM system is capable of delivering the optical parameters necessary for therapeutic treatment.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:41 |
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| Enthalten in: |
Photobiomodulation, photomedicine, and laser surgery - 41(2023), 11 vom: 25. Nov., Seite 622-631 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Agbele, Alaba Tolulope [VerfasserIn] |
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| Links: |
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| Themen: |
Cytokines |
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| Anmerkungen: |
Date Completed 27.11.2023 Date Revised 27.11.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1089/photob.2023.0021 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM363821775 |
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| 100 | 1 | |a Agbele, Alaba Tolulope |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Development and Application of Prototype System Based on Light-Emitting Diode Arrays (660 nm) with a Top Hat Beam Profile in Order to Optimize Photobiomodulation Protocols for Treatment of Radiation-Induced Oral Mucositis in Rats |
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| 500 | |a Date Revised 27.11.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Background: Oral mucositis (OM) is a common adverse effect of radiation to the head and neck. Recent research has shown that extra oral photobiomodulation (EO-PBM) reduces the severity of OM. However, appropriate EO-PBM therapy parameters for OM severity reduction have not been documented. Objective: This work aims to optimize EO-PBM radiation parameters for lowering the severity of radiation-induced OM in rats by establishing a photobiomodulation (PBM) treatment system based on light-emitting diode arrays with top-hat beam profile. Methods: The 36 rats are separated into 2 control groups and 4 groups receiving PBM treatment. The PBM groups are exposed to irradiance between 4 and 24 J/cm2 at 660 nm. The cheek pouch mucosa is removed after scarification for biochemical and histological examination. Student's t-test, and one-way analysis of variance (ANOVA) followed by Tukey's Multiple were applied to compare the statistical significance of differences between control groups and PBM treatment groups. Results: Statistical analysis reveals that PBM irradiation at 12 J/cm2 (200 sec) with a flatness of 0.8 and a diameter of 3 cm substantially decreased the level of inflammatory cytokines compared with the positive control group. Conclusions: Our results indicate that the designed treatment PBM system is capable of delivering the optical parameters necessary for therapeutic treatment | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a head and neck radiotherapy | |
| 650 | 4 | |a low-level light therapy | |
| 650 | 4 | |a oral mucositis | |
| 650 | 4 | |a photobiomodulation | |
| 650 | 4 | |a phototherapy | |
| 650 | 4 | |a prototype photobiomodulation treatment system | |
| 650 | 4 | |a top-hat beam profile | |
| 650 | 7 | |a Cytokines |2 NLM | |
| 700 | 1 | |a Dehpour, Ahmad Reza |e verfasserin |4 aut | |
| 700 | 1 | |a Jafari, Razieh Mohammad |e verfasserin |4 aut | |
| 700 | 1 | |a Mahdavi, Seyed Rabi Mehdi |e verfasserin |4 aut | |
| 700 | 1 | |a Elyassi, Arash |e verfasserin |4 aut | |
| 700 | 1 | |a Seydi, Mojtaba |e verfasserin |4 aut | |
| 700 | 1 | |a Bagheri, Mahmood |e verfasserin |4 aut | |
| 700 | 1 | |a Ala, Moein |e verfasserin |4 aut | |
| 700 | 1 | |a Roudsari, Babak Arji |e verfasserin |4 aut | |
| 700 | 1 | |a Hejazi, Marjaneh |e verfasserin |4 aut | |
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