A Population-Based Outcome-Wide Association Study of the Comorbidities and Sequelae Following COVID-19 Infection
© 2023. The Author(s)..
BACKGROUND: Immense attention has been given to the outcome of COVID-19 infection. However, comprehensive studies based on large populational cohort with long-term follow-up are still lacking. This study aimed to investigate the risk of various short-term comorbidities (within one month) and long-term sequelae (above one month) after COVID-19 infection.
METHODS: In this large prospective cohort study with 14 months follow-up information based on UK biobank, we included 16,776 COVID-19-positive participants and 58,281 COVID-19-negative participants matched for comparison. The risk of each comorbidity and sequela was evaluated by multivariable logistic regression analysis and presented as hazard ratio (HR) and 95% confidence interval (95% CI).
RESULTS: COVID-19-positive individuals had a higher risk of 47 types of comorbidities within one month following COVID-19 infection, especially those who were older, male, overweight/obese, ever-smoked, with more pre-existing comorbidities and hospitalized. About 70.37% of COVID-19 patients with comorbidities had more than one co-occurring comorbidities. Additionally, only 6 high-risk sequelae were observed after one month of COVID-19 infection, and the incidence was relatively low (< 1%).
CONCLUSION: In addition to long-term sequelae following COVID-19 infection, plenty of comorbidities were observed, especially in patients with older age, male gender, overweight/obese, more pre-existing comorbidities and severe COVID-19, indicating that more attention should be given to these susceptible persons within this period.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:13 |
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| Enthalten in: |
Journal of epidemiology and global health - 13(2023), 4 vom: 27. Dez., Seite 870-885 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Zhang, Yuyang [VerfasserIn] |
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| Links: |
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| Themen: |
COVID-19 |
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| Anmerkungen: |
Date Completed 30.11.2023 Date Revised 01.12.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s44197-023-00161-w |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM363815015 |
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| 245 | 1 | 2 | |a A Population-Based Outcome-Wide Association Study of the Comorbidities and Sequelae Following COVID-19 Infection |
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| 500 | |a Date Revised 01.12.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2023. The Author(s). | ||
| 520 | |a BACKGROUND: Immense attention has been given to the outcome of COVID-19 infection. However, comprehensive studies based on large populational cohort with long-term follow-up are still lacking. This study aimed to investigate the risk of various short-term comorbidities (within one month) and long-term sequelae (above one month) after COVID-19 infection | ||
| 520 | |a METHODS: In this large prospective cohort study with 14 months follow-up information based on UK biobank, we included 16,776 COVID-19-positive participants and 58,281 COVID-19-negative participants matched for comparison. The risk of each comorbidity and sequela was evaluated by multivariable logistic regression analysis and presented as hazard ratio (HR) and 95% confidence interval (95% CI) | ||
| 520 | |a RESULTS: COVID-19-positive individuals had a higher risk of 47 types of comorbidities within one month following COVID-19 infection, especially those who were older, male, overweight/obese, ever-smoked, with more pre-existing comorbidities and hospitalized. About 70.37% of COVID-19 patients with comorbidities had more than one co-occurring comorbidities. Additionally, only 6 high-risk sequelae were observed after one month of COVID-19 infection, and the incidence was relatively low (< 1%) | ||
| 520 | |a CONCLUSION: In addition to long-term sequelae following COVID-19 infection, plenty of comorbidities were observed, especially in patients with older age, male gender, overweight/obese, more pre-existing comorbidities and severe COVID-19, indicating that more attention should be given to these susceptible persons within this period | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a Comorbidity | |
| 650 | 4 | |a Incidence | |
| 650 | 4 | |a Long-term sequelae | |
| 650 | 4 | |a Outcome-wide association study | |
| 700 | 1 | |a Li, Junhong |e verfasserin |4 aut | |
| 700 | 1 | |a Feng, Lan |e verfasserin |4 aut | |
| 700 | 1 | |a Luo, Yaxin |e verfasserin |4 aut | |
| 700 | 1 | |a Pang, Wendu |e verfasserin |4 aut | |
| 700 | 1 | |a Qiu, Ke |e verfasserin |4 aut | |
| 700 | 1 | |a Mao, Minzi |e verfasserin |4 aut | |
| 700 | 1 | |a Song, Yao |e verfasserin |4 aut | |
| 700 | 1 | |a Cheng, Danni |e verfasserin |4 aut | |
| 700 | 1 | |a Rao, Yufang |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Xinyi |e verfasserin |4 aut | |
| 700 | 1 | |a Hu, Yao |e verfasserin |4 aut | |
| 700 | 1 | |a Ying, Zhiye |e verfasserin |4 aut | |
| 700 | 1 | |a Pu, Xiaobin |e verfasserin |4 aut | |
| 700 | 1 | |a Lin, Shuyan |e verfasserin |4 aut | |
| 700 | 1 | |a Huang, Shaohui |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Geoffrey |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Wei |e verfasserin |4 aut | |
| 700 | 1 | |a Xu, Wei |e verfasserin |4 aut | |
| 700 | 1 | |a Zhao, Yu |e verfasserin |4 aut | |
| 700 | 1 | |a Ren, Jianjun |e verfasserin |4 aut | |
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