Capecitabine-Induced Ileitis during Neoadjuvant Pelvic Radio-Chemotherapy for Locally Advanced Rectal Cancer : A Case Report with Literature Review
We report on a clinical case of capecitabine-induced acute ileitis in a patient treated with pre-operative concurrent chemoradiation with capecitabine for locally advanced rectal cancer and provide a comprehensive literature review. This a rare, but life-threatening, clinical situation, that clinicians should be aware of. Severe persistent diarrhea is the most frequent clinical feature and computed tomography is a valid tool for diagnosis. Conservative management includes capecitabine withdrawal, antidiarrheal therapy and endovenous hydration, together with dietary modifications and broad-spectrum antibiotics. Pelvic irradiation represents an adjunctive risk factor, which may increase the likelihood of occurrence of terminal ileitis. Early recognition and prompt intervention are crucial for successful clinical management.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:30 |
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| Enthalten in: |
Current oncology (Toronto, Ont.) - 30(2023), 10 vom: 10. Okt., Seite 9063-9077 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Brignoli, Andrea [VerfasserIn] |
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| Links: |
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| Themen: |
6804DJ8Z9U |
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| Anmerkungen: |
Date Completed 30.10.2023 Date Revised 01.11.2023 published: Electronic Citation Status MEDLINE |
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| doi: |
10.3390/curroncol30100655 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM36379624X |
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| 520 | |a We report on a clinical case of capecitabine-induced acute ileitis in a patient treated with pre-operative concurrent chemoradiation with capecitabine for locally advanced rectal cancer and provide a comprehensive literature review. This a rare, but life-threatening, clinical situation, that clinicians should be aware of. Severe persistent diarrhea is the most frequent clinical feature and computed tomography is a valid tool for diagnosis. Conservative management includes capecitabine withdrawal, antidiarrheal therapy and endovenous hydration, together with dietary modifications and broad-spectrum antibiotics. Pelvic irradiation represents an adjunctive risk factor, which may increase the likelihood of occurrence of terminal ileitis. Early recognition and prompt intervention are crucial for successful clinical management | ||
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| 700 | 1 | |a Loi, Gianfranco |e verfasserin |4 aut | |
| 700 | 1 | |a Forti, Laura |e verfasserin |4 aut | |
| 700 | 1 | |a Socci, Carlo |e verfasserin |4 aut | |
| 700 | 1 | |a Carriero, Alessandro |e verfasserin |4 aut | |
| 700 | 1 | |a Gennari, Alessandra |e verfasserin |4 aut | |
| 700 | 1 | |a Krengli, Marco |e verfasserin |4 aut | |
| 700 | 1 | |a Franco, Pierfrancesco |e verfasserin |4 aut | |
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