No association between inactivated influenza vaccination and influenza viral load at diagnosis among young Japanese children : An observational study of the 2013/2014 through 2017/2018 influenza seasons
© 2023 The Authors. Influenza and Other Respiratory Viruses published by John Wiley & Sons Ltd..
BACKGROUND: The association between inactivated influenza vaccination and viral load in young children remains unclear.
METHODS: During the 2013/2014 to 2017/2018 influenza seasons in Japan, children under 6 years of age with pre-defined influenza-like illness and influenza-positive status by real-time RT-PCR were recruited at pediatric clinics for this observational study. Influenza viral load was measured for the most predominant subtype/lineage in each season. Using median dichotomized viral load as an outcome, a multilevel logistic regression model was applied to estimate the multivariable adjusted odds ratio (MOR) and 95% confidence interval (CI) for higher viral load.
RESULTS: A total of 1,185 influenza-positive children were analyzed. The median log10 viral load copy number (copies per milliliter) was 5.5 (interquartile range, 4.6 to 6.1) and did not differ by vaccination status: 5.5 for unvaccinated, 5.7 for one dose, and 5.5 for two doses (p = 0.67). The MOR of vaccinated (one or two doses) versus unvaccinated children was 1.19 (95% CI: 0.86-1.64). Other factors showing significant associations with higher viral load were positive results for A(H1N1)pdm09 and A(H3N2) in comparison with B/Yamagata. The respective MORs were 3.25 (95% CI: 2.28-4.64) and 1.81 (95% CI: 1.32-2.49). Significantly elevated MORs against higher viral load were also observed for higher body temperature at influenza diagnosis and shorter duration from fever onset to specimen collection.
CONCLUSION: No association was observed between inactivated-influenza vaccination and viral load at influenza-positive diagnosis. Influenza subtype/lineage, body temperature, and time elapsed since fever onset were significantly associated with viral load.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:17 |
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| Enthalten in: |
Influenza and other respiratory viruses - 17(2023), 10 vom: 27. Okt., Seite e13213 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Mukai, Emiko [VerfasserIn] |
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| Links: |
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| Themen: |
Fever |
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| Anmerkungen: |
Date Completed 30.10.2023 Date Revised 30.10.2023 published: Print Citation Status MEDLINE |
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| doi: |
10.1111/irv.13213 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM363774416 |
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| 100 | 1 | |a Mukai, Emiko |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a No association between inactivated influenza vaccination and influenza viral load at diagnosis among young Japanese children |b An observational study of the 2013/2014 through 2017/2018 influenza seasons |
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| 500 | |a Date Revised 30.10.2023 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2023 The Authors. Influenza and Other Respiratory Viruses published by John Wiley & Sons Ltd. | ||
| 520 | |a BACKGROUND: The association between inactivated influenza vaccination and viral load in young children remains unclear | ||
| 520 | |a METHODS: During the 2013/2014 to 2017/2018 influenza seasons in Japan, children under 6 years of age with pre-defined influenza-like illness and influenza-positive status by real-time RT-PCR were recruited at pediatric clinics for this observational study. Influenza viral load was measured for the most predominant subtype/lineage in each season. Using median dichotomized viral load as an outcome, a multilevel logistic regression model was applied to estimate the multivariable adjusted odds ratio (MOR) and 95% confidence interval (CI) for higher viral load | ||
| 520 | |a RESULTS: A total of 1,185 influenza-positive children were analyzed. The median log10 viral load copy number (copies per milliliter) was 5.5 (interquartile range, 4.6 to 6.1) and did not differ by vaccination status: 5.5 for unvaccinated, 5.7 for one dose, and 5.5 for two doses (p = 0.67). The MOR of vaccinated (one or two doses) versus unvaccinated children was 1.19 (95% CI: 0.86-1.64). Other factors showing significant associations with higher viral load were positive results for A(H1N1)pdm09 and A(H3N2) in comparison with B/Yamagata. The respective MORs were 3.25 (95% CI: 2.28-4.64) and 1.81 (95% CI: 1.32-2.49). Significantly elevated MORs against higher viral load were also observed for higher body temperature at influenza diagnosis and shorter duration from fever onset to specimen collection | ||
| 520 | |a CONCLUSION: No association was observed between inactivated-influenza vaccination and viral load at influenza-positive diagnosis. Influenza subtype/lineage, body temperature, and time elapsed since fever onset were significantly associated with viral load | ||
| 650 | 4 | |a Observational Study | |
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| 700 | 1 | |a Fujioka, Masashi |e verfasserin |4 aut | |
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