Liraglutide and Liver Injury : Rare Case Report with Literature Review
Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.net..
BACKGROUND: Liraglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist used for the treatment of type 2 diabetes mellitus (T2DM). So far, few severe side effects have been reported for it.
CASE PRESENTATION: A 41-year-old woman was admitted to the Emergency Room with diffuse abdominal pain. The patient had a known case of T2DM, fatty liver disease, and hypertension and was treated with Metformin, Liraglutide, and Losartan. Her liver functional test (LFT) was consistent with hepatocellular injury; however, laboratory tests and abdominal ultrasound were used to rule out autoimmune hepatitis. Due to concerns for drug-induced liver injury (DILL), liraglutide was discontinued and N-acetyl cysteine was prescribed. On the fifth day of hospitalization, the patient's symptoms resolved and his LFT started to decrease on the sixth day after 2 months, the patient's liver enzyme levels returned to normal.
CONCLUSION: Liraglutide is one of the most important drugs in the treatment of T2DM.The most common side effects of this drug are constipation, nausea, vomiting, diarrhea, indigestion, and loss of appetite. In rare cases, symptoms of thyroid cancer, pancreatitis, and hypoglycemia have been reported, however, DILL is one of the extremely rare side effect of Liraglutide. It is important to increase the awareness of physicians about the liver injury of Liraglutide.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2024 |
---|---|
Erschienen: |
2024 |
Enthalten in: |
Zur Gesamtaufnahme - volume:24 |
---|---|
Enthalten in: |
Endocrine, metabolic & immune disorders drug targets - 24(2024), 6 vom: 20., Seite 725-729 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Salehi, Amir Mohammad [VerfasserIn] |
---|
Links: |
---|
Themen: |
839I73S42A |
---|
Anmerkungen: |
Date Completed 22.02.2024 Date Revised 22.02.2024 published: Print Citation Status MEDLINE |
---|
doi: |
10.2174/0118715303180615231011053011 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM363771867 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | NLM363771867 | ||
003 | DE-627 | ||
005 | 20240222232056.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231226s2024 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.2174/0118715303180615231011053011 |2 doi | |
028 | 5 | 2 | |a pubmed24n1302.xml |
035 | |a (DE-627)NLM363771867 | ||
035 | |a (NLM)37885115 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Salehi, Amir Mohammad |e verfasserin |4 aut | |
245 | 1 | 0 | |a Liraglutide and Liver Injury |b Rare Case Report with Literature Review |
264 | 1 | |c 2024 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 22.02.2024 | ||
500 | |a Date Revised 22.02.2024 | ||
500 | |a published: Print | ||
500 | |a Citation Status MEDLINE | ||
520 | |a Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.net. | ||
520 | |a BACKGROUND: Liraglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist used for the treatment of type 2 diabetes mellitus (T2DM). So far, few severe side effects have been reported for it | ||
520 | |a CASE PRESENTATION: A 41-year-old woman was admitted to the Emergency Room with diffuse abdominal pain. The patient had a known case of T2DM, fatty liver disease, and hypertension and was treated with Metformin, Liraglutide, and Losartan. Her liver functional test (LFT) was consistent with hepatocellular injury; however, laboratory tests and abdominal ultrasound were used to rule out autoimmune hepatitis. Due to concerns for drug-induced liver injury (DILL), liraglutide was discontinued and N-acetyl cysteine was prescribed. On the fifth day of hospitalization, the patient's symptoms resolved and his LFT started to decrease on the sixth day after 2 months, the patient's liver enzyme levels returned to normal | ||
520 | |a CONCLUSION: Liraglutide is one of the most important drugs in the treatment of T2DM.The most common side effects of this drug are constipation, nausea, vomiting, diarrhea, indigestion, and loss of appetite. In rare cases, symptoms of thyroid cancer, pancreatitis, and hypoglycemia have been reported, however, DILL is one of the extremely rare side effect of Liraglutide. It is important to increase the awareness of physicians about the liver injury of Liraglutide | ||
650 | 4 | |a Review | |
650 | 4 | |a Case Reports | |
650 | 4 | |a Drug-induced liver injury | |
650 | 4 | |a GLP-1 | |
650 | 4 | |a LFT | |
650 | 4 | |a Liraglutide | |
650 | 4 | |a Type 2 diabetes mellitus | |
650 | 4 | |a diarrhea | |
650 | 4 | |a hypoglycemia. | |
650 | 7 | |a Liraglutide |2 NLM | |
650 | 7 | |a 839I73S42A |2 NLM | |
650 | 7 | |a Hypoglycemic Agents |2 NLM | |
650 | 7 | |a Glucagon-Like Peptide 1 |2 NLM | |
650 | 7 | |a 89750-14-1 |2 NLM | |
700 | 1 | |a Hasanzarrini, Maryam |e verfasserin |4 aut | |
700 | 1 | |a Salehi, Hossain |e verfasserin |4 aut | |
700 | 1 | |a Jenabi, Ensiyeh |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Endocrine, metabolic & immune disorders drug targets |d 2006 |g 24(2024), 6 vom: 20., Seite 725-729 |w (DE-627)NLM161976174 |x 2212-3873 |7 nnns |
773 | 1 | 8 | |g volume:24 |g year:2024 |g number:6 |g day:20 |g pages:725-729 |
856 | 4 | 0 | |u http://dx.doi.org/10.2174/0118715303180615231011053011 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 24 |j 2024 |e 6 |b 20 |h 725-729 |