The Anti-hypoxia Potentials of Trans-sodium Crocetinate in Hypoxiarelated Diseases : A Review
Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.net..
Crocetin is a kind of apocarotenoid carboxylic acid extracted from saffron (Crocus sativus L.), which is effective in upregulating tissue oxygenation. However, crocetin is difficult to solubilize. It was shown that the trans isomer of crocetin is effective in improving oxygen diffusivity, while its cis isomer appears not to be. Hence, the isolated trans isomer of crocetin or trans-sodium crocetinate (TSC) can be used instead of crocetin. It is shown that TSC can upregulate hypoxic tissue oxygenation and be effective in treating some hypoxia-related diseases. Moreover, experimental and clinical studies have reported no adverse effects following TSC treatment, even at high doses. The current study will discuss the potential role of TSC in hemorrhagic shock, ischemia, brain tumor radiotherapy, and others.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2023 |
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| Enthalten in: |
Current radiopharmaceuticals - (2023) vom: 24. Okt. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Klunko, Natalia S [VerfasserIn] |
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| Links: |
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| Themen: |
Brain tumor |
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| Anmerkungen: |
Date Revised 25.10.2023 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.2174/0118744710268127231020083505 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM363697349 |
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| 520 | |a Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.net. | ||
| 520 | |a Crocetin is a kind of apocarotenoid carboxylic acid extracted from saffron (Crocus sativus L.), which is effective in upregulating tissue oxygenation. However, crocetin is difficult to solubilize. It was shown that the trans isomer of crocetin is effective in improving oxygen diffusivity, while its cis isomer appears not to be. Hence, the isolated trans isomer of crocetin or trans-sodium crocetinate (TSC) can be used instead of crocetin. It is shown that TSC can upregulate hypoxic tissue oxygenation and be effective in treating some hypoxia-related diseases. Moreover, experimental and clinical studies have reported no adverse effects following TSC treatment, even at high doses. The current study will discuss the potential role of TSC in hemorrhagic shock, ischemia, brain tumor radiotherapy, and others | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Brain tumor | |
| 650 | 4 | |a Hemorrhagic shock | |
| 650 | 4 | |a Ischemia | |
| 650 | 4 | |a Oxygenation | |
| 650 | 4 | |a Radiotherapy | |
| 650 | 4 | |a Trans sodium crocetinate | |
| 700 | 1 | |a Achmad, Harun |e verfasserin |4 aut | |
| 700 | 1 | |a Abdullah, Tamara Muayad |e verfasserin |4 aut | |
| 700 | 1 | |a Mohammed, Sami |e verfasserin |4 aut | |
| 700 | 1 | |a Saha, Indranil |e verfasserin |4 aut | |
| 700 | 1 | |a Salim, Khulood Saadoon |e verfasserin |4 aut | |
| 700 | 1 | |a Obaid, Rasha Fadhel |e verfasserin |4 aut | |
| 700 | 1 | |a Romero-Parra, Rosario Mireya |e verfasserin |4 aut | |
| 700 | 1 | |a Al-Hasnawi, Shaker Shanawa |e verfasserin |4 aut | |
| 700 | 1 | |a Al-Janabi, Wissam Hamid |e verfasserin |4 aut | |
| 700 | 1 | |a Farhood, Bagher |e verfasserin |4 aut | |
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