Extending the cystatin C based EKFC-equation to children - validation results from Europe
© 2023. The Author(s), under exclusive licence to International Pediatric Nephrology Association..
BACKGROUND: A new cystatin C based European Kidney Function Consortium (EKFCCysC) equation was recently developed for adults, using the same mathematical form as the previously published full age spectrum creatinine based EKFC-equation (EKFCCrea). In the present study the cystatin C based EKFC-equation is extended to children, by defining the appropriate cystatin C rescaling factor QCysC.
METHODS: Rescaling factor QCysC for cystatin C was defined as: a) 0.83 mg/L, exactly as it was defined for young adults in the adult equation, and b) a more complex QCysC-age relationship based on 4th degree cystatin C-age polynomials after evaluation of data from Uppsala, Stockholm and Canada and aggregated data from Germany. The EKFCCysC equation was then validated in an independent dataset in European children (n = 2,293) with measured GFR, creatinine, cystatin C, age, height and sex available.
RESULTS: The EKFCCysC with the simple QCysC-value of 0.83 had a bias of -7.6 [95%CI -8.4;-6.5] mL/min/1.73 m2 and a P30-value of 85.8% [95%CI 84.4;87.3] equal to the EKFCCysC with the more complex 4th degree QCysC-value. The arithmetic mean of the EKFCCrea and EKFCCysC with the simple QCysC of 0.83 had a bias of -4.0 [95%CI -4.5;-3.1] mL/min/1.73 m2 and P30 of 90.4% [95%CI 89.2;91.6] similar to using the more complex 4th degree QCysC-polynomial.
CONCLUSION: Using exactly the same QCysC of 0.83 mg/L, the adult EKFCCysC can easily be extended to children, with some bias but acceptable P30-values. The arithmetic mean of EKFCCrea and EKFCCysC results in bias closer to zero and P30 slightly over 90%.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2024 |
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Erschienen: |
2024 |
Enthalten in: |
Zur Gesamtaufnahme - volume:39 |
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Enthalten in: |
Pediatric nephrology (Berlin, Germany) - 39(2024), 4 vom: 01. März, Seite 1177-1183 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Pottel, Hans [VerfasserIn] |
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Themen: |
AYI8EX34EU |
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Anmerkungen: |
Date Completed 28.02.2024 Date Revised 04.03.2024 published: Print-Electronic Citation Status MEDLINE |
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doi: |
10.1007/s00467-023-06192-6 |
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funding: |
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PPN (Katalog-ID): |
NLM363679863 |
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520 | |a © 2023. The Author(s), under exclusive licence to International Pediatric Nephrology Association. | ||
520 | |a BACKGROUND: A new cystatin C based European Kidney Function Consortium (EKFCCysC) equation was recently developed for adults, using the same mathematical form as the previously published full age spectrum creatinine based EKFC-equation (EKFCCrea). In the present study the cystatin C based EKFC-equation is extended to children, by defining the appropriate cystatin C rescaling factor QCysC | ||
520 | |a METHODS: Rescaling factor QCysC for cystatin C was defined as: a) 0.83 mg/L, exactly as it was defined for young adults in the adult equation, and b) a more complex QCysC-age relationship based on 4th degree cystatin C-age polynomials after evaluation of data from Uppsala, Stockholm and Canada and aggregated data from Germany. The EKFCCysC equation was then validated in an independent dataset in European children (n = 2,293) with measured GFR, creatinine, cystatin C, age, height and sex available | ||
520 | |a RESULTS: The EKFCCysC with the simple QCysC-value of 0.83 had a bias of -7.6 [95%CI -8.4;-6.5] mL/min/1.73 m2 and a P30-value of 85.8% [95%CI 84.4;87.3] equal to the EKFCCysC with the more complex 4th degree QCysC-value. The arithmetic mean of the EKFCCrea and EKFCCysC with the simple QCysC of 0.83 had a bias of -4.0 [95%CI -4.5;-3.1] mL/min/1.73 m2 and P30 of 90.4% [95%CI 89.2;91.6] similar to using the more complex 4th degree QCysC-polynomial | ||
520 | |a CONCLUSION: Using exactly the same QCysC of 0.83 mg/L, the adult EKFCCysC can easily be extended to children, with some bias but acceptable P30-values. The arithmetic mean of EKFCCrea and EKFCCysC results in bias closer to zero and P30 slightly over 90% | ||
650 | 4 | |a Journal Article | |
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650 | 4 | |a Cystatin C | |
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700 | 1 | |a Björk, Jonas |e verfasserin |4 aut | |
700 | 1 | |a Berg, Ulla |e verfasserin |4 aut | |
700 | 1 | |a Bökenkamp, Arend |e verfasserin |4 aut | |
700 | 1 | |a Dubourg, Laurence Derain |e verfasserin |4 aut | |
700 | 1 | |a Lemoine, Sandrine |e verfasserin |4 aut | |
700 | 1 | |a Goffin, Karolien |e verfasserin |4 aut | |
700 | 1 | |a Grubb, Anders |e verfasserin |4 aut | |
700 | 1 | |a Hansson, Magnus |e verfasserin |4 aut | |
700 | 1 | |a Larsson, Anders |e verfasserin |4 aut | |
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700 | 1 | |a Delanaye, Pierre |e verfasserin |4 aut | |
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