Single-anastomosis duodeno-ileal bypass with sleeve gastrectomy improves lipid and glucose homeostasis in ob/ob mice
© 2023 The Obesity Society..
OBJECTIVE: The objective of this study was to compare the general and metabolic impact of single-anastomosis duodeno-ileal bypass with sleeve gastrectomy (SADI-S) with Roux-en-Y gastric bypass (RYGB) in an obese (ob/ob) mouse model.
METHODS: 10-week-old male ob/ob mice underwent either SADI-S, RYGB, or laparotomy surgery (Sham group). General and metabolic parameters were assessed during a 5-week period thereafter.
RESULTS: SADI-S induced a deeper weight loss ([mean ± SEM] -41.2% ± 3.3%) than RYGB (-5.6% ± 3.5%, p < 0.001) compared with the Sham group (+6.3% ± 1.0%, p < 0.05). A significant food restriction was observed after SADI-S only (-31%, 117.4 ± 10.3 g vs. 170.2 ± 5.2 g of food at day 35 in Sham group mice, p < 0.001). Random-fed glycemia and glucose tolerance were more improved after SADI-S than RYGB. SADI-S decreased plasma cholesterol concentration by 60% (0.49 ± 0.04 g/L vs. 1.40 ± 0.10 g/L in the Sham group at day 35, p < 0.01), significantly more than RYGB (1.04 ± 0.14 g/L, p = 0.018). Plasma sitosterol/cholesterol and campesterol/cholesterol ratios were decreased after SADI-S, suggesting a reduced intestinal cholesterol absorption. SADI-S increased exogenous plasma cholesterol-D7 clearance and fecal elimination, also indicating an increased plasma cholesterol excretion. Studying a pair-fed group demonstrated that calorie restriction alone did not explain the beneficial impact of SADI-S.
CONCLUSIONS: SADI-S is associated with a greater improvement in lipid and glucose homeostasis than RYGB in ob/ob mice.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2024 |
---|---|
Erschienen: |
2024 |
Enthalten in: |
Zur Gesamtaufnahme - volume:32 |
---|---|
Enthalten in: |
Obesity (Silver Spring, Md.) - 32(2024), 1 vom: 01. Jan., Seite 91-106 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Frey, Samuel [VerfasserIn] |
---|
Links: |
---|
Themen: |
97C5T2UQ7J |
---|
Anmerkungen: |
Date Completed 21.02.2024 Date Revised 21.02.2024 published: Print-Electronic Citation Status MEDLINE |
---|
doi: |
10.1002/oby.23916 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM363675159 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | NLM363675159 | ||
003 | DE-627 | ||
005 | 20240222232053.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231226s2024 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1002/oby.23916 |2 doi | |
028 | 5 | 2 | |a pubmed24n1302.xml |
035 | |a (DE-627)NLM363675159 | ||
035 | |a (NLM)37875256 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Frey, Samuel |e verfasserin |4 aut | |
245 | 1 | 0 | |a Single-anastomosis duodeno-ileal bypass with sleeve gastrectomy improves lipid and glucose homeostasis in ob/ob mice |
264 | 1 | |c 2024 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 21.02.2024 | ||
500 | |a Date Revised 21.02.2024 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a © 2023 The Obesity Society. | ||
520 | |a OBJECTIVE: The objective of this study was to compare the general and metabolic impact of single-anastomosis duodeno-ileal bypass with sleeve gastrectomy (SADI-S) with Roux-en-Y gastric bypass (RYGB) in an obese (ob/ob) mouse model | ||
520 | |a METHODS: 10-week-old male ob/ob mice underwent either SADI-S, RYGB, or laparotomy surgery (Sham group). General and metabolic parameters were assessed during a 5-week period thereafter | ||
520 | |a RESULTS: SADI-S induced a deeper weight loss ([mean ± SEM] -41.2% ± 3.3%) than RYGB (-5.6% ± 3.5%, p < 0.001) compared with the Sham group (+6.3% ± 1.0%, p < 0.05). A significant food restriction was observed after SADI-S only (-31%, 117.4 ± 10.3 g vs. 170.2 ± 5.2 g of food at day 35 in Sham group mice, p < 0.001). Random-fed glycemia and glucose tolerance were more improved after SADI-S than RYGB. SADI-S decreased plasma cholesterol concentration by 60% (0.49 ± 0.04 g/L vs. 1.40 ± 0.10 g/L in the Sham group at day 35, p < 0.01), significantly more than RYGB (1.04 ± 0.14 g/L, p = 0.018). Plasma sitosterol/cholesterol and campesterol/cholesterol ratios were decreased after SADI-S, suggesting a reduced intestinal cholesterol absorption. SADI-S increased exogenous plasma cholesterol-D7 clearance and fecal elimination, also indicating an increased plasma cholesterol excretion. Studying a pair-fed group demonstrated that calorie restriction alone did not explain the beneficial impact of SADI-S | ||
520 | |a CONCLUSIONS: SADI-S is associated with a greater improvement in lipid and glucose homeostasis than RYGB in ob/ob mice | ||
650 | 4 | |a Evaluation Study | |
650 | 4 | |a Journal Article | |
650 | 7 | |a Cholesterol |2 NLM | |
650 | 7 | |a 97C5T2UQ7J |2 NLM | |
650 | 7 | |a Glucose |2 NLM | |
650 | 7 | |a IY9XDZ35W2 |2 NLM | |
650 | 7 | |a Lipids |2 NLM | |
700 | 1 | |a Ayer, Audrey |e verfasserin |4 aut | |
700 | 1 | |a Sotin, Thibaud |e verfasserin |4 aut | |
700 | 1 | |a Lorant, Victoria |e verfasserin |4 aut | |
700 | 1 | |a Louis-Gaubert, Clément |e verfasserin |4 aut | |
700 | 1 | |a Arnaud, Lucie |e verfasserin |4 aut | |
700 | 1 | |a Billon-Crossouard, Stéphanie |e verfasserin |4 aut | |
700 | 1 | |a Croyal, Mikael |e verfasserin |4 aut | |
700 | 1 | |a Prieur, Xavier |e verfasserin |4 aut | |
700 | 1 | |a Hadjadj, Samy |e verfasserin |4 aut | |
700 | 1 | |a Cariou, Bertrand |e verfasserin |4 aut | |
700 | 1 | |a Blanchard, Claire |e verfasserin |4 aut | |
700 | 1 | |a Le May, Cédric |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Obesity (Silver Spring, Md.) |d 2006 |g 32(2024), 1 vom: 01. Jan., Seite 91-106 |w (DE-627)NLM160857384 |x 1930-739X |7 nnns |
773 | 1 | 8 | |g volume:32 |g year:2024 |g number:1 |g day:01 |g month:01 |g pages:91-106 |
856 | 4 | 0 | |u http://dx.doi.org/10.1002/oby.23916 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 32 |j 2024 |e 1 |b 01 |c 01 |h 91-106 |