A genomic appraisal of invasive Salmonella Typhimurium and associated antibiotic resistance in sub-Saharan Africa
© 2023. Springer Nature Limited..
Invasive non-typhoidal Salmonella (iNTS) disease manifesting as bloodstream infection with high mortality is responsible for a huge public health burden in sub-Saharan Africa. Salmonella enterica serovar Typhimurium (S. Typhimurium) is the main cause of iNTS disease in Africa. By analysing whole genome sequence data from 1303 S. Typhimurium isolates originating from 19 African countries and isolated between 1979 and 2017, here we show a thorough scaled appraisal of the population structure of iNTS disease caused by S. Typhimurium across many of Africa's most impacted countries. At least six invasive S. Typhimurium clades have already emerged, with ST313 lineage 2 or ST313-L2 driving the current pandemic. ST313-L2 likely emerged in the Democratic Republic of Congo around 1980 and further spread in the mid 1990s. We observed plasmid-borne as well as chromosomally encoded fluoroquinolone resistance underlying emergences of extensive-drug and pan-drug resistance. Our work provides an overview of the evolution of invasive S. Typhimurium disease, and can be exploited to target control measures.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:14 |
|---|---|
| Enthalten in: |
Nature communications - 14(2023), 1 vom: 23. Okt., Seite 6392 |
| Sprache: |
Englisch |
|---|
| Links: |
|---|
| Themen: |
|---|
| Anmerkungen: |
Date Completed 30.10.2023 Date Revised 10.02.2024 published: Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1038/s41467-023-41152-6 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM363644296 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM363644296 | ||
| 003 | DE-627 | ||
| 005 | 20240210232800.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/s41467-023-41152-6 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1286.xml |
| 035 | |a (DE-627)NLM363644296 | ||
| 035 | |a (NLM)37872141 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Van Puyvelde, Sandra |e verfasserin |4 aut | |
| 245 | 1 | 2 | |a A genomic appraisal of invasive Salmonella Typhimurium and associated antibiotic resistance in sub-Saharan Africa |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 30.10.2023 | ||
| 500 | |a Date Revised 10.02.2024 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2023. Springer Nature Limited. | ||
| 520 | |a Invasive non-typhoidal Salmonella (iNTS) disease manifesting as bloodstream infection with high mortality is responsible for a huge public health burden in sub-Saharan Africa. Salmonella enterica serovar Typhimurium (S. Typhimurium) is the main cause of iNTS disease in Africa. By analysing whole genome sequence data from 1303 S. Typhimurium isolates originating from 19 African countries and isolated between 1979 and 2017, here we show a thorough scaled appraisal of the population structure of iNTS disease caused by S. Typhimurium across many of Africa's most impacted countries. At least six invasive S. Typhimurium clades have already emerged, with ST313 lineage 2 or ST313-L2 driving the current pandemic. ST313-L2 likely emerged in the Democratic Republic of Congo around 1980 and further spread in the mid 1990s. We observed plasmid-borne as well as chromosomally encoded fluoroquinolone resistance underlying emergences of extensive-drug and pan-drug resistance. Our work provides an overview of the evolution of invasive S. Typhimurium disease, and can be exploited to target control measures | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 700 | 1 | |a de Block, Tessa |e verfasserin |4 aut | |
| 700 | 1 | |a Sridhar, Sushmita |e verfasserin |4 aut | |
| 700 | 1 | |a Bawn, Matt |e verfasserin |4 aut | |
| 700 | 1 | |a Kingsley, Robert A |e verfasserin |4 aut | |
| 700 | 1 | |a Ingelbeen, Brecht |e verfasserin |4 aut | |
| 700 | 1 | |a Beale, Mathew A |e verfasserin |4 aut | |
| 700 | 1 | |a Barbé, Barbara |e verfasserin |4 aut | |
| 700 | 1 | |a Jeon, Hyon Jin |e verfasserin |4 aut | |
| 700 | 1 | |a Mbuyi-Kalonji, Lisette |e verfasserin |4 aut | |
| 700 | 1 | |a Phoba, Marie-France |e verfasserin |4 aut | |
| 700 | 1 | |a Falay, Dadi |e verfasserin |4 aut | |
| 700 | 1 | |a Martiny, Delphine |e verfasserin |4 aut | |
| 700 | 1 | |a Vandenberg, Olivier |e verfasserin |4 aut | |
| 700 | 1 | |a Affolabi, Dissou |e verfasserin |4 aut | |
| 700 | 1 | |a Rutanga, Jean Pierre |e verfasserin |4 aut | |
| 700 | 1 | |a Ceyssens, Pieter-Jan |e verfasserin |4 aut | |
| 700 | 1 | |a Mattheus, Wesley |e verfasserin |4 aut | |
| 700 | 1 | |a Cuypers, Wim L |e verfasserin |4 aut | |
| 700 | 1 | |a van der Sande, Marianne A B |e verfasserin |4 aut | |
| 700 | 1 | |a Park, Se Eun |e verfasserin |4 aut | |
| 700 | 1 | |a Kariuki, Simon |e verfasserin |4 aut | |
| 700 | 1 | |a Otieno, Kephas |e verfasserin |4 aut | |
| 700 | 1 | |a Lusingu, John P A |e verfasserin |4 aut | |
| 700 | 1 | |a Mbwana, Joyce R |e verfasserin |4 aut | |
| 700 | 1 | |a Adjei, Samuel |e verfasserin |4 aut | |
| 700 | 1 | |a Sarfo, Anima |e verfasserin |4 aut | |
| 700 | 1 | |a Agyei, Seth O |e verfasserin |4 aut | |
| 700 | 1 | |a Asante, Kwaku P |e verfasserin |4 aut | |
| 700 | 1 | |a Otieno, Walter |e verfasserin |4 aut | |
| 700 | 1 | |a Otieno, Lucas |e verfasserin |4 aut | |
| 700 | 1 | |a Tahita, Marc C |e verfasserin |4 aut | |
| 700 | 1 | |a Lompo, Palpouguini |e verfasserin |4 aut | |
| 700 | 1 | |a Hoffman, Irving F |e verfasserin |4 aut | |
| 700 | 1 | |a Mvalo, Tisungane |e verfasserin |4 aut | |
| 700 | 1 | |a Msefula, Chisomo |e verfasserin |4 aut | |
| 700 | 1 | |a Hassan-Hanga, Fatimah |e verfasserin |4 aut | |
| 700 | 1 | |a Obaro, Stephen |e verfasserin |4 aut | |
| 700 | 1 | |a Mackenzie, Grant |e verfasserin |4 aut | |
| 700 | 1 | |a Deborggraeve, Stijn |e verfasserin |4 aut | |
| 700 | 1 | |a Feasey, Nicholas |e verfasserin |4 aut | |
| 700 | 1 | |a Marks, Florian |e verfasserin |4 aut | |
| 700 | 1 | |a MacLennan, Calman A |e verfasserin |4 aut | |
| 700 | 1 | |a Thomson, Nicholas R |e verfasserin |4 aut | |
| 700 | 1 | |a Jacobs, Jan |e verfasserin |4 aut | |
| 700 | 1 | |a Dougan, Gordon |e verfasserin |4 aut | |
| 700 | 1 | |a Kariuki, Samuel |e verfasserin |4 aut | |
| 700 | 1 | |a Lunguya, Octavie |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Nature communications |d 2010 |g 14(2023), 1 vom: 23. Okt., Seite 6392 |w (DE-627)NLM199274525 |x 2041-1723 |7 nnns |
| 773 | 1 | 8 | |g volume:14 |g year:2023 |g number:1 |g day:23 |g month:10 |g pages:6392 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1038/s41467-023-41152-6 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 14 |j 2023 |e 1 |b 23 |c 10 |h 6392 | ||