Role and mechanism of PVN-sympathetic-adipose circuit in depression and insulin resistance induced by chronic stress
© 2023 The Authors. Published under the terms of the CC BY NC ND 4.0 license..
Chronic stress induces depression and insulin resistance, between which there is a bidirectional relationship. However, the mechanisms underlying this comorbidity remain unclear. White adipose tissue (WAT), innervated by sympathetic nerves, serves as a central node in the interorgan crosstalk through adipokines. Abnormal secretion of adipokines is involved in mood disorders and metabolic morbidities. We describe here a brain-sympathetic nerve-adipose circuit originating in the hypothalamic paraventricular nucleus (PVN) with a role in depression and insulin resistance induced by chronic stress. PVN neurons are labelled after inoculation of pseudorabies virus (PRV) into WAT and are activated under restraint stress. Chemogenetic manipulations suggest a role for the PVN in depression and insulin resistance. Chronic stress increases the sympathetic innervation of WAT and downregulates several antidepressant and insulin-sensitizing adipokines, including leptin, adiponectin, Angptl4 and Sfrp5. Chronic activation of the PVN has similar effects. β-adrenergic receptors translate sympathetic tone into an adipose response, inducing downregulation of those adipokines and depressive-like behaviours and insulin resistance. We finally show that AP-1 has a role in the regulation of adipokine expression under chronic stress.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:24 |
|---|---|
| Enthalten in: |
EMBO reports - 24(2023), 12 vom: 06. Dez., Seite e57176 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Wang, Jing [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Adipokines |
|---|
| Anmerkungen: |
Date Completed 11.12.2023 Date Revised 11.12.2023 published: Print-Electronic GEO: GSE216370 Citation Status MEDLINE |
|---|
| doi: |
10.15252/embr.202357176 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM36362709X |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM36362709X | ||
| 003 | DE-627 | ||
| 005 | 20231227131816.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.15252/embr.202357176 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1226.xml |
| 035 | |a (DE-627)NLM36362709X | ||
| 035 | |a (NLM)37870400 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Wang, Jing |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Role and mechanism of PVN-sympathetic-adipose circuit in depression and insulin resistance induced by chronic stress |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 11.12.2023 | ||
| 500 | |a Date Revised 11.12.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a GEO: GSE216370 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2023 The Authors. Published under the terms of the CC BY NC ND 4.0 license. | ||
| 520 | |a Chronic stress induces depression and insulin resistance, between which there is a bidirectional relationship. However, the mechanisms underlying this comorbidity remain unclear. White adipose tissue (WAT), innervated by sympathetic nerves, serves as a central node in the interorgan crosstalk through adipokines. Abnormal secretion of adipokines is involved in mood disorders and metabolic morbidities. We describe here a brain-sympathetic nerve-adipose circuit originating in the hypothalamic paraventricular nucleus (PVN) with a role in depression and insulin resistance induced by chronic stress. PVN neurons are labelled after inoculation of pseudorabies virus (PRV) into WAT and are activated under restraint stress. Chemogenetic manipulations suggest a role for the PVN in depression and insulin resistance. Chronic stress increases the sympathetic innervation of WAT and downregulates several antidepressant and insulin-sensitizing adipokines, including leptin, adiponectin, Angptl4 and Sfrp5. Chronic activation of the PVN has similar effects. β-adrenergic receptors translate sympathetic tone into an adipose response, inducing downregulation of those adipokines and depressive-like behaviours and insulin resistance. We finally show that AP-1 has a role in the regulation of adipokine expression under chronic stress | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a adipokines | |
| 650 | 4 | |a depression | |
| 650 | 4 | |a hypothalamic paraventricular nucleus (PVN) | |
| 650 | 4 | |a insulin resistance | |
| 650 | 4 | |a sympathetic nerve | |
| 650 | 7 | |a Adipokines |2 NLM | |
| 700 | 1 | |a Sun, Linshan |e verfasserin |4 aut | |
| 700 | 1 | |a You, Jingjing |e verfasserin |4 aut | |
| 700 | 1 | |a Peng, Honghai |e verfasserin |4 aut | |
| 700 | 1 | |a Yan, Haijing |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Jiangong |e verfasserin |4 aut | |
| 700 | 1 | |a Sun, Fengjiao |e verfasserin |4 aut | |
| 700 | 1 | |a Cui, Minghu |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Sanwang |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Zheng |e verfasserin |4 aut | |
| 700 | 1 | |a Fan, Xueli |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Dunjiang |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Cuilan |e verfasserin |4 aut | |
| 700 | 1 | |a Qiu, Changyun |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Chao |e verfasserin |4 aut | |
| 700 | 1 | |a Xu, Zhicheng |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Jinbo |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Wei |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Bin |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t EMBO reports |d 2000 |g 24(2023), 12 vom: 06. Dez., Seite e57176 |w (DE-627)NLM111633540 |x 1469-3178 |7 nnns |
| 773 | 1 | 8 | |g volume:24 |g year:2023 |g number:12 |g day:06 |g month:12 |g pages:e57176 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.15252/embr.202357176 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 24 |j 2023 |e 12 |b 06 |c 12 |h e57176 | ||