CircNOLC1 Promotes Colorectal Cancer Liver Metastasis by Interacting with AZGP1 and Sponging miR-212-5p to Regulate Reprogramming of the Oxidative Pentose Phosphate Pathway
© 2023 The Authors. Advanced Science published by Wiley-VCH GmbH..
Liver metastasis is a common cause of death in progressive colorectal cancer patients, but the molecular mechanisms remain unclear. Here, it is reported that a conserved and oxidative pentose phosphate pathway-associated circular RNA, circNOLC1, plays a crucial role in colorectal cancer liver metastasis. It is found that circNOLC1 silencing reduces the oxidative pentose phosphate pathway-related intermediate metabolites and elevates NADP+ /NADPH ratio and intracellular ROS levels, thereby attenuating colorectal cancer cell proliferation, migration, and liver metastasis. circNOLC1 interacting with AZGP1 to activate mTOR/SREBP1 signaling, or sponging miR-212-5p to upregulate c-Met expression, both of which can further induce G6PD to activate oxidative pentose phosphate pathway in colorectal cancer liver metastasis. Moreover, circNOLC1 is regulated by the transcription factor YY1 and specifically stabilized HuR induces its parental gene mRNA expression. The associations between circNOLC1 and these signaling molecules are validated in primary CRC and corresponding liver metastasis tissues. These findings reveal that circNOLC1 interacting with AZGP1 and circNOLC1/miR-212-5p/c-Met axis plays a key role in oxidative pentose phosphate pathway-mediated colorectal cancer liver metastasis, which may provide a novel target for precision medicine of colorectal cancer.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:10 |
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| Enthalten in: |
Advanced science (Weinheim, Baden-Wurttemberg, Germany) - 10(2023), 33 vom: 23. Nov., Seite e2205229 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Yuan, Menglang [VerfasserIn] |
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| Links: |
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| Themen: |
AZGP1 |
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| Anmerkungen: |
Date Completed 27.11.2023 Date Revised 27.11.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1002/advs.202205229 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 245 | 1 | 0 | |a CircNOLC1 Promotes Colorectal Cancer Liver Metastasis by Interacting with AZGP1 and Sponging miR-212-5p to Regulate Reprogramming of the Oxidative Pentose Phosphate Pathway |
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| 500 | |a published: Print-Electronic | ||
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| 520 | |a © 2023 The Authors. Advanced Science published by Wiley-VCH GmbH. | ||
| 520 | |a Liver metastasis is a common cause of death in progressive colorectal cancer patients, but the molecular mechanisms remain unclear. Here, it is reported that a conserved and oxidative pentose phosphate pathway-associated circular RNA, circNOLC1, plays a crucial role in colorectal cancer liver metastasis. It is found that circNOLC1 silencing reduces the oxidative pentose phosphate pathway-related intermediate metabolites and elevates NADP+ /NADPH ratio and intracellular ROS levels, thereby attenuating colorectal cancer cell proliferation, migration, and liver metastasis. circNOLC1 interacting with AZGP1 to activate mTOR/SREBP1 signaling, or sponging miR-212-5p to upregulate c-Met expression, both of which can further induce G6PD to activate oxidative pentose phosphate pathway in colorectal cancer liver metastasis. Moreover, circNOLC1 is regulated by the transcription factor YY1 and specifically stabilized HuR induces its parental gene mRNA expression. The associations between circNOLC1 and these signaling molecules are validated in primary CRC and corresponding liver metastasis tissues. These findings reveal that circNOLC1 interacting with AZGP1 and circNOLC1/miR-212-5p/c-Met axis plays a key role in oxidative pentose phosphate pathway-mediated colorectal cancer liver metastasis, which may provide a novel target for precision medicine of colorectal cancer | ||
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| 700 | 1 | |a Zhang, Xinsheng |e verfasserin |4 aut | |
| 700 | 1 | |a Yue, Fangxia |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Feifan |e verfasserin |4 aut | |
| 700 | 1 | |a Jiang, Sufen |e verfasserin |4 aut | |
| 700 | 1 | |a Zhou, Xu |e verfasserin |4 aut | |
| 700 | 1 | |a Lv, Jinjuan |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Zhenyu |e verfasserin |4 aut | |
| 700 | 1 | |a Sun, Yuzhu |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Zihao |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Han |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Xiaoqian |e verfasserin |4 aut | |
| 700 | 1 | |a Yu, Xiaoqi |e verfasserin |4 aut | |
| 700 | 1 | |a Wei, Bowen |e verfasserin |4 aut | |
| 700 | 1 | |a Jiang, Kexin |e verfasserin |4 aut | |
| 700 | 1 | |a Lin, Fang |e verfasserin |4 aut | |
| 700 | 1 | |a Zuo, Yunfei |e verfasserin |4 aut | |
| 700 | 1 | |a Ren, Shuangyi |e verfasserin |4 aut | |
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