Assessing potential of psilocybin for depressive disorders

INTRODUCTION: There has been increasing interest in the role psilocybin may play in the treatment of depressive disorders. Several clinical trials have shown psilocybin to have efficacy in reducing symptoms of depression.

AREASCOVERED: We discuss the current understanding of psilocybin's therapeutic mechanism of action and review existing clinical data investigating psilocybin as a novel therapeutic agent for the treatment of depression.

EXPERT OPINION: There is still much unknown regarding the risks of psilocybin treatment. When weighing the known risks and benefits of psilocybin treatment against those found in existing standards of care, among patients with depression, patients with treatment-resistant depression (TRD) may be the most suitable candidates for psilocybin treatment at this time.

Medienart:

E-Artikel

Erscheinungsjahr:

2023

Erschienen:

2023

Enthalten in:

Zur Gesamtaufnahme - volume:32

Enthalten in:

Expert opinion on investigational drugs - 32(2023), 10 vom: 20. Juli, Seite 887-900

Sprache:

Englisch

Beteiligte Personen:

Kozak, Zofia [VerfasserIn]
Johnson, Matthew W [VerfasserIn]
Aaronson, Scott T [VerfasserIn]

Links:

Volltext

Themen:

2RV7212BP0
Depression in chronic illness
Hallucinogens
Journal Article
Major depressive disorder
Psilocybin
Psilocybin, psychedelics
Psychedelic-assisted therapy
Review
Treatment-resistant depression

Anmerkungen:

Date Completed 07.11.2023

Date Revised 07.11.2023

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1080/13543784.2023.2273493

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM36362113X