The comparison of antioxidant properties and nutrigenomic redox-related activities of vitamin C, C-vitamers, and other common ascorbic acid derivatives
Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved..
The term 'vitamin C' describes a group of compounds with antiscorbutic activity of l-ascorbic acid (AA). Despite AA's omnipresence in plant-derived foods, its derivatives have also been successfully implemented in the food industry as antioxidants, including the D-isomers, which lack vitamin C activity. This study aimed to determine the relationship between redox-related activities for five derivatives of AA using electrochemical, chemical, and biological approaches. Here we report that AA, C-vitamers, and other commonly consumed AA derivatives differ in their redox-related activities. As long as the physiological range of concentrations was maintained, there was no simple relationship between their redox properties and biological activity. Clear distinctions in antioxidant activity were observed mostly at high concentrations, which were strongly correlated with electrochemical and kinetic parameters describing redox-related properties of the studied compounds. Despite obvious similarities in chemical structures and antioxidant activity, we showed that C-vitamers may exhibit different nutrigenomic effects. Together, our findings provide a deeper insight into so far underinvestigated area combining chemical properties with biological activities of commonly applied AA derivatives.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:209 |
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| Enthalten in: |
Free radical biology & medicine - 209(2023), Pt 2 vom: 20. Nov., Seite 239-251 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Jakubek, Patrycja [VerfasserIn] |
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| Links: |
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| Themen: |
Antioxidant activity |
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| Anmerkungen: |
Date Completed 21.11.2023 Date Revised 18.02.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.freeradbiomed.2023.10.400 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM363590803 |
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| 245 | 1 | 4 | |a The comparison of antioxidant properties and nutrigenomic redox-related activities of vitamin C, C-vitamers, and other common ascorbic acid derivatives |
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| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved. | ||
| 520 | |a The term 'vitamin C' describes a group of compounds with antiscorbutic activity of l-ascorbic acid (AA). Despite AA's omnipresence in plant-derived foods, its derivatives have also been successfully implemented in the food industry as antioxidants, including the D-isomers, which lack vitamin C activity. This study aimed to determine the relationship between redox-related activities for five derivatives of AA using electrochemical, chemical, and biological approaches. Here we report that AA, C-vitamers, and other commonly consumed AA derivatives differ in their redox-related activities. As long as the physiological range of concentrations was maintained, there was no simple relationship between their redox properties and biological activity. Clear distinctions in antioxidant activity were observed mostly at high concentrations, which were strongly correlated with electrochemical and kinetic parameters describing redox-related properties of the studied compounds. Despite obvious similarities in chemical structures and antioxidant activity, we showed that C-vitamers may exhibit different nutrigenomic effects. Together, our findings provide a deeper insight into so far underinvestigated area combining chemical properties with biological activities of commonly applied AA derivatives | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Antioxidant activity | |
| 650 | 4 | |a Essential nutrients | |
| 650 | 4 | |a Gene expression | |
| 650 | 4 | |a Oxidative damage | |
| 650 | 4 | |a Redox homeostasis | |
| 650 | 7 | |a Antioxidants |2 NLM | |
| 650 | 7 | |a Ascorbic Acid |2 NLM | |
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| 650 | 7 | |a Vitamins |2 NLM | |
| 700 | 1 | |a Suliborska, Klaudia |e verfasserin |4 aut | |
| 700 | 1 | |a Kuczyńska, Monika |e verfasserin |4 aut | |
| 700 | 1 | |a Asaduzzaman, Muhammad |e verfasserin |4 aut | |
| 700 | 1 | |a Parchem, Karol |e verfasserin |4 aut | |
| 700 | 1 | |a Koss-Mikołajczyk, Izabela |e verfasserin |4 aut | |
| 700 | 1 | |a Kusznierewicz, Barbara |e verfasserin |4 aut | |
| 700 | 1 | |a Chrzanowski, Wojciech |e verfasserin |4 aut | |
| 700 | 1 | |a Namieśnik, Jacek |e verfasserin |4 aut | |
| 700 | 1 | |a Bartoszek, Agnieszka |e verfasserin |4 aut | |
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