Age, successive waves, immunization, and mortality in elderly COVID-19 hematological patients : EPICOVIDEHA findings
Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved..
OBJECTIVES: Elderly patients with hematologic malignancies face the highest risk of severe COVID-19 outcomes. The infection's impact on different age groups remains unstudied in detail.
METHODS: We analyzed elderly patients (age groups: 65-70, 71-75, 76-80, and >80 years old) with hematologic malignancies included in the EPICOVIDEHA registry between January 2020 and July 2022. Univariable and multivariable Cox regression models were conducted to identify factors influencing death in COVID-19 patients with hematological malignancy.
RESULTS: The study included data from 3,603 elderly patients (aged 65 or older) with hematological malignancy, with a majority being male (58.1%) and a significant proportion having comorbidities. The patients were divided into four age groups, and the analysis assessed COVID-19 outcomes, vaccination status, and other variables in relation to age and pandemic waves. The 90-day survival rate for patients with COVID-19 was 71.2%, with significant differences between groups. The pandemic waves had varying impacts, with the first wave affecting patients over 80 years old, the second being more severe in 65-70, and the third being the least severe in all age groups. Factors contributing to 90-day mortality included age, comorbidities, lymphopenia, active malignancy, acute leukemia, less than three vaccine doses, severe COVID-19, and using only corticosteroids as treatment.
CONCLUSION: These data underscore the heterogeneity of elderly hematological patients, highlight the different impacts of COVID-19 waves and the pivotal importance of vaccination, and may help in planning future healthcare efforts.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2023 |
---|---|
Erschienen: |
2023 |
Enthalten in: |
Zur Gesamtaufnahme - volume:137 |
---|---|
Enthalten in: |
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases - 137(2023) vom: 19. Dez., Seite 98-110 |
Sprache: |
Englisch |
---|
Links: |
---|
Themen: |
COVID-19 |
---|
Anmerkungen: |
Date Completed 04.12.2023 Date Revised 04.12.2023 published: Print-Electronic Citation Status MEDLINE |
---|
doi: |
10.1016/j.ijid.2023.10.013 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM363556605 |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM363556605 | ||
003 | DE-627 | ||
005 | 20231226093611.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231226s2023 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1016/j.ijid.2023.10.013 |2 doi | |
028 | 5 | 2 | |a pubmed24n1211.xml |
035 | |a (DE-627)NLM363556605 | ||
035 | |a (NLM)37863310 | ||
035 | |a (PII)S1201-9712(23)00749-X | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Rossi, Giuseppe |e verfasserin |4 aut | |
245 | 1 | 0 | |a Age, successive waves, immunization, and mortality in elderly COVID-19 hematological patients |b EPICOVIDEHA findings |
264 | 1 | |c 2023 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 04.12.2023 | ||
500 | |a Date Revised 04.12.2023 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved. | ||
520 | |a OBJECTIVES: Elderly patients with hematologic malignancies face the highest risk of severe COVID-19 outcomes. The infection's impact on different age groups remains unstudied in detail | ||
520 | |a METHODS: We analyzed elderly patients (age groups: 65-70, 71-75, 76-80, and >80 years old) with hematologic malignancies included in the EPICOVIDEHA registry between January 2020 and July 2022. Univariable and multivariable Cox regression models were conducted to identify factors influencing death in COVID-19 patients with hematological malignancy | ||
520 | |a RESULTS: The study included data from 3,603 elderly patients (aged 65 or older) with hematological malignancy, with a majority being male (58.1%) and a significant proportion having comorbidities. The patients were divided into four age groups, and the analysis assessed COVID-19 outcomes, vaccination status, and other variables in relation to age and pandemic waves. The 90-day survival rate for patients with COVID-19 was 71.2%, with significant differences between groups. The pandemic waves had varying impacts, with the first wave affecting patients over 80 years old, the second being more severe in 65-70, and the third being the least severe in all age groups. Factors contributing to 90-day mortality included age, comorbidities, lymphopenia, active malignancy, acute leukemia, less than three vaccine doses, severe COVID-19, and using only corticosteroids as treatment | ||
520 | |a CONCLUSION: These data underscore the heterogeneity of elderly hematological patients, highlight the different impacts of COVID-19 waves and the pivotal importance of vaccination, and may help in planning future healthcare efforts | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a COVID-19 | |
650 | 4 | |a Elderly | |
650 | 4 | |a Hematological malignancy | |
650 | 4 | |a High-risk patient | |
650 | 4 | |a SARS-CoV-2 | |
700 | 1 | |a Salmanton-García, Jon |e verfasserin |4 aut | |
700 | 1 | |a Cattaneo, Chiara |e verfasserin |4 aut | |
700 | 1 | |a Marchesi, Francesco |e verfasserin |4 aut | |
700 | 1 | |a Dávila-Valls, Julio |e verfasserin |4 aut | |
700 | 1 | |a Martín-Pérez, Sonia |e verfasserin |4 aut | |
700 | 1 | |a Itri, Federico |e verfasserin |4 aut | |
700 | 1 | |a López-García, Alberto |e verfasserin |4 aut | |
700 | 1 | |a Glenthøj, Andreas |e verfasserin |4 aut | |
700 | 1 | |a Gomes da Silva, Maria |e verfasserin |4 aut | |
700 | 1 | |a Besson, Caroline |e verfasserin |4 aut | |
700 | 1 | |a Marchetti, Monia |e verfasserin |4 aut | |
700 | 1 | |a Weinbergerová, Barbora |e verfasserin |4 aut | |
700 | 1 | |a Jaksic, Ozren |e verfasserin |4 aut | |
700 | 1 | |a Jiménez, Moraima |e verfasserin |4 aut | |
700 | 1 | |a Bilgin, Yavuz M |e verfasserin |4 aut | |
700 | 1 | |a Van Doesum, Jaap |e verfasserin |4 aut | |
700 | 1 | |a Farina, Francesca |e verfasserin |4 aut | |
700 | 1 | |a Žák, Pavel |e verfasserin |4 aut | |
700 | 1 | |a Verga, Luisa |e verfasserin |4 aut | |
700 | 1 | |a Collins, Graham P |e verfasserin |4 aut | |
700 | 1 | |a Bonuomo, Valentina |e verfasserin |4 aut | |
700 | 1 | |a Van Praet, Jens |e verfasserin |4 aut | |
700 | 1 | |a Nucci, Marcio |e verfasserin |4 aut | |
700 | 1 | |a Meers, Stef |e verfasserin |4 aut | |
700 | 1 | |a Espigado, Ildefonso |e verfasserin |4 aut | |
700 | 1 | |a Fracchiolla, Nicola S |e verfasserin |4 aut | |
700 | 1 | |a Valković, Toni |e verfasserin |4 aut | |
700 | 1 | |a Poulsen, Christian Bjørn |e verfasserin |4 aut | |
700 | 1 | |a Čolović, Natasha |e verfasserin |4 aut | |
700 | 1 | |a Dragonetti, Giulia |e verfasserin |4 aut | |
700 | 1 | |a Ledoux, Marie-Pierre |e verfasserin |4 aut | |
700 | 1 | |a Tascini, Carlo |e verfasserin |4 aut | |
700 | 1 | |a Buquicchio, Caterina |e verfasserin |4 aut | |
700 | 1 | |a Blennow, Ola |e verfasserin |4 aut | |
700 | 1 | |a Passamonti, Francesco |e verfasserin |4 aut | |
700 | 1 | |a Machado, Marina |e verfasserin |4 aut | |
700 | 1 | |a Labrador, Jorge |e verfasserin |4 aut | |
700 | 1 | |a Duarte, Rafael F |e verfasserin |4 aut | |
700 | 1 | |a Schönlein, Martin |e verfasserin |4 aut | |
700 | 1 | |a Prezioso, Lucia |e verfasserin |4 aut | |
700 | 1 | |a Falces-Romero, Iker |e verfasserin |4 aut | |
700 | 1 | |a Kulasekararaj, Austin |e verfasserin |4 aut | |
700 | 1 | |a Garcia-Vidal, Carolina |e verfasserin |4 aut | |
700 | 1 | |a Fernández, Noemí |e verfasserin |4 aut | |
700 | 1 | |a Abu-Zeinah, Ghaith |e verfasserin |4 aut | |
700 | 1 | |a Ormazabal-Vélez, Irati |e verfasserin |4 aut | |
700 | 1 | |a Adžić-Vukičević, Tatjana |e verfasserin |4 aut | |
700 | 1 | |a Piukovics, Klára |e verfasserin |4 aut | |
700 | 1 | |a Stoma, Igor |e verfasserin |4 aut | |
700 | 1 | |a Cuccaro, Annarosa |e verfasserin |4 aut | |
700 | 1 | |a Magliano, Gabriele |e verfasserin |4 aut | |
700 | 1 | |a Szotkowski, Tomáš |e verfasserin |4 aut | |
700 | 1 | |a González-López, Tomás-José |e verfasserin |4 aut | |
700 | 1 | |a El-Ashwah, Shaimaa |e verfasserin |4 aut | |
700 | 1 | |a Bergantim, Rui |e verfasserin |4 aut | |
700 | 1 | |a Sili, Uluhan |e verfasserin |4 aut | |
700 | 1 | |a Maertens, Johan |e verfasserin |4 aut | |
700 | 1 | |a Demirkan, Fatih |e verfasserin |4 aut | |
700 | 1 | |a De Ramón, Cristina |e verfasserin |4 aut | |
700 | 1 | |a Petzer, Verena |e verfasserin |4 aut | |
700 | 1 | |a Del Principe, Maria Ilaria |e verfasserin |4 aut | |
700 | 1 | |a Navrátil, Milan |e verfasserin |4 aut | |
700 | 1 | |a Dargenio, Michelina |e verfasserin |4 aut | |
700 | 1 | |a Seval, Guldane Cengiz |e verfasserin |4 aut | |
700 | 1 | |a Samarkos, Michail |e verfasserin |4 aut | |
700 | 1 | |a Ráčil, Zdeněk |e verfasserin |4 aut | |
700 | 1 | |a Pinczés, László Imre |e verfasserin |4 aut | |
700 | 1 | |a Lahmer, Tobias |e verfasserin |4 aut | |
700 | 1 | |a Busca, Alessandro |e verfasserin |4 aut | |
700 | 1 | |a Méndez, Gustavo-Adolfo |e verfasserin |4 aut | |
700 | 1 | |a Vena, Antonio |e verfasserin |4 aut | |
700 | 1 | |a Biernat, Monika M |e verfasserin |4 aut | |
700 | 1 | |a Merelli, Maria |e verfasserin |4 aut | |
700 | 1 | |a Calbacho, Maria |e verfasserin |4 aut | |
700 | 1 | |a Barać, Aleksandra |e verfasserin |4 aut | |
700 | 1 | |a Bavastro, Martina |e verfasserin |4 aut | |
700 | 1 | |a Limongelli, Alessandro |e verfasserin |4 aut | |
700 | 1 | |a Ilhan, Osman |e verfasserin |4 aut | |
700 | 1 | |a Wolf, Dominik |e verfasserin |4 aut | |
700 | 1 | |a Çolak, Gökçe Melis |e verfasserin |4 aut | |
700 | 1 | |a García-Sanz, Ramón |e verfasserin |4 aut | |
700 | 1 | |a Emarah, Ziad |e verfasserin |4 aut | |
700 | 1 | |a Mišković, Bojana |e verfasserin |4 aut | |
700 | 1 | |a Gräfe, Stefanie K |e verfasserin |4 aut | |
700 | 1 | |a Mladenović, Miloš |e verfasserin |4 aut | |
700 | 1 | |a Aiello, Tommaso Francesco |e verfasserin |4 aut | |
700 | 1 | |a Núñez-Martín-Buitrago, Lucía |e verfasserin |4 aut | |
700 | 1 | |a Nordlander, Anna |e verfasserin |4 aut | |
700 | 1 | |a Arellano, Elena |e verfasserin |4 aut | |
700 | 1 | |a Zambrotta, Giovanni Paolo Maria |e verfasserin |4 aut | |
700 | 1 | |a Ammatuna, Emanuele |e verfasserin |4 aut | |
700 | 1 | |a Cabirta, Alba |e verfasserin |4 aut | |
700 | 1 | |a Sacchi, Maria Vittoria |e verfasserin |4 aut | |
700 | 1 | |a Nunes Rodrigues, Raquel |e verfasserin |4 aut | |
700 | 1 | |a Hersby, Ditte Stampe |e verfasserin |4 aut | |
700 | 1 | |a Hanakova, Michaela |e verfasserin |4 aut | |
700 | 1 | |a Rahimli, Laman |e verfasserin |4 aut | |
700 | 1 | |a Cordoba, Raul |e verfasserin |4 aut | |
700 | 1 | |a Cornely, Oliver A |e verfasserin |4 aut | |
700 | 0 | |a Collaborators |e verfasserin |4 aut | |
700 | 0 | |a et al |4 oth | |
773 | 0 | 8 | |i Enthalten in |t International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases |d 1998 |g 137(2023) vom: 19. Dez., Seite 98-110 |w (DE-627)NLM094730857 |x 1878-3511 |7 nnns |
773 | 1 | 8 | |g volume:137 |g year:2023 |g day:19 |g month:12 |g pages:98-110 |
856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.ijid.2023.10.013 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 137 |j 2023 |b 19 |c 12 |h 98-110 |