The genetic and environmental contributions to variation in the permanent dental arch form : a twin study
© The Author(s) 2023. Published by Oxford University Press on behalf of the European Orthodontic Society..
OBJECTIVE: The objective of this study was to examine the relative contributions of genetic and environmental influences on variation in dental arch form in individuals who have largely completed their craniofacial growth.
MATERIAL AND METHODS: The subjects of this study comprised dental casts of 50 monozygotic twins and 24 dizygotic twins from the collection of records of twins housed at the Adelaide Dental School, Australia. The subjects were of Western European descent, with an average age of 20.93 ± 5.58 years. Dental casts were scanned using a 3D scanner to analyse the dental arch form. Landmark-based inter-arch and intra-arch measurements were performed. Structural equation modelling was employed to analyse the quantitative data using the normal assumptions of the twin model.
RESULTS: Genetic modelling revealed that additive genetic and unique environmental factors best explained the observed variation for all occlusal traits measured, except for mandibular intercanine width. High heritability was observed for most intra-arch occlusal variables (0.61-0.85) including the maxillary and mandibular intercanine and intermolar widths, arch depth and perimeter. In contrast, moderate heritability was found for inter-arch occlusal variables (0.52-0.59) such as overjet and overbite. Sexual dimorphism was evident, with males displaying larger posterior arch width than females (P < 0.05).
LIMITATIONS: Our sample was limited to individuals of Western European ancestry.
CONCLUSION: The predominant source of occlusal variation within this group of Australian twins of Western European descent was controlled by genetic effects, and most were highly heritable. Generally, intra-arch occlusal variables showed greater heritability compared with inter-arch occlusal variables.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:45 |
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| Enthalten in: |
European journal of orthodontics - 45(2023), 6 vom: 30. Nov., Seite 868-874 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Lin, Ting-Han [VerfasserIn] |
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| Links: |
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| Themen: |
Craniofacial development |
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| Anmerkungen: |
Date Completed 01.12.2023 Date Revised 03.01.2024 published: Print Citation Status MEDLINE |
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| doi: |
10.1093/ejo/cjad054 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 245 | 1 | 4 | |a The genetic and environmental contributions to variation in the permanent dental arch form |b a twin study |
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| 500 | |a Date Completed 01.12.2023 | ||
| 500 | |a Date Revised 03.01.2024 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © The Author(s) 2023. Published by Oxford University Press on behalf of the European Orthodontic Society. | ||
| 520 | |a OBJECTIVE: The objective of this study was to examine the relative contributions of genetic and environmental influences on variation in dental arch form in individuals who have largely completed their craniofacial growth | ||
| 520 | |a MATERIAL AND METHODS: The subjects of this study comprised dental casts of 50 monozygotic twins and 24 dizygotic twins from the collection of records of twins housed at the Adelaide Dental School, Australia. The subjects were of Western European descent, with an average age of 20.93 ± 5.58 years. Dental casts were scanned using a 3D scanner to analyse the dental arch form. Landmark-based inter-arch and intra-arch measurements were performed. Structural equation modelling was employed to analyse the quantitative data using the normal assumptions of the twin model | ||
| 520 | |a RESULTS: Genetic modelling revealed that additive genetic and unique environmental factors best explained the observed variation for all occlusal traits measured, except for mandibular intercanine width. High heritability was observed for most intra-arch occlusal variables (0.61-0.85) including the maxillary and mandibular intercanine and intermolar widths, arch depth and perimeter. In contrast, moderate heritability was found for inter-arch occlusal variables (0.52-0.59) such as overjet and overbite. Sexual dimorphism was evident, with males displaying larger posterior arch width than females (P < 0.05) | ||
| 520 | |a LIMITATIONS: Our sample was limited to individuals of Western European ancestry | ||
| 520 | |a CONCLUSION: The predominant source of occlusal variation within this group of Australian twins of Western European descent was controlled by genetic effects, and most were highly heritable. Generally, intra-arch occlusal variables showed greater heritability compared with inter-arch occlusal variables | ||
| 650 | 4 | |a Twin Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a craniofacial development | |
| 650 | 4 | |a eruption problems | |
| 650 | 4 | |a genetics | |
| 650 | 4 | |a hypodontia | |
| 650 | 4 | |a impacted teeth | |
| 650 | 4 | |a occlusal development | |
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| 700 | 1 | |a Meade, Maurice J |e verfasserin |4 aut | |
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