Using peripheral immune-inflammatory blood markers in tumors treated with immune checkpoint inhibitors : An INVIDIa-2 study sub-analysis
© 2023 The Authors..
The neutrophil-to-lymphocyte ratio (NLR) and systemic immune-inflammatory index (SII) have been reported as prognosticators in non-small cell lung cancer (NSCLC), renal cell carcinoma (RCC), and melanoma. This analysis of the INVIDIa-2 study on influenza vaccination in patients with cancer treated with immune checkpoint inhibitors (ICIs) assessed NLR and SII on overall survival (OS) by literature-reported (LR), receiver operating characteristic curve (ROC)-derived (ROC) cutoffs or as continuous variable (CV). NLR and SII with ROC cutoffs of <3.4 (p < 0.001) and <831 (p < 0.001) were independent factors for OS in multivariate analysis. SII with LR, ROC, or CV significantly predicted OS in NSCLC (p = 0.002, p = 0.003, p = 0.003), RCC (p = 0.034, p = 0.014, p = 0.014), and melanoma (p = 0.038, p = 0.022, p = 0.019). NLR with LR and ROC cutoffs predicted OS in first line (p < 0.001 for both) and second line or beyond (p = 0.006 for both); likewise SII (p < 0.001; p = 0.002 and p < 0.001). NLR and SII are prognosticators in NSCLC, RCC, and melanoma treated with ICIs.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:26 |
|---|---|
| Enthalten in: |
iScience - 26(2023), 11 vom: 17. Nov., Seite 107970 |
| Sprache: |
Englisch |
|---|
| Links: |
|---|
| Themen: |
|---|
| Anmerkungen: |
Date Revised 03.04.2024 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
|---|
| doi: |
10.1016/j.isci.2023.107970 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM363530991 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM363530991 | ||
| 003 | DE-627 | ||
| 005 | 20240403235001.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.isci.2023.107970 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1362.xml |
| 035 | |a (DE-627)NLM363530991 | ||
| 035 | |a (NLM)37860695 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Anpalakhan, Shobana |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Using peripheral immune-inflammatory blood markers in tumors treated with immune checkpoint inhibitors |b An INVIDIa-2 study sub-analysis |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Revised 03.04.2024 | ||
| 500 | |a published: Electronic-eCollection | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a © 2023 The Authors. | ||
| 520 | |a The neutrophil-to-lymphocyte ratio (NLR) and systemic immune-inflammatory index (SII) have been reported as prognosticators in non-small cell lung cancer (NSCLC), renal cell carcinoma (RCC), and melanoma. This analysis of the INVIDIa-2 study on influenza vaccination in patients with cancer treated with immune checkpoint inhibitors (ICIs) assessed NLR and SII on overall survival (OS) by literature-reported (LR), receiver operating characteristic curve (ROC)-derived (ROC) cutoffs or as continuous variable (CV). NLR and SII with ROC cutoffs of <3.4 (p < 0.001) and <831 (p < 0.001) were independent factors for OS in multivariate analysis. SII with LR, ROC, or CV significantly predicted OS in NSCLC (p = 0.002, p = 0.003, p = 0.003), RCC (p = 0.034, p = 0.014, p = 0.014), and melanoma (p = 0.038, p = 0.022, p = 0.019). NLR with LR and ROC cutoffs predicted OS in first line (p < 0.001 for both) and second line or beyond (p = 0.006 for both); likewise SII (p < 0.001; p = 0.002 and p < 0.001). NLR and SII are prognosticators in NSCLC, RCC, and melanoma treated with ICIs | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Immune response | |
| 650 | 4 | |a Immunity | |
| 650 | 4 | |a Immunology | |
| 700 | 1 | |a Signori, Alessio |e verfasserin |4 aut | |
| 700 | 1 | |a Cortellini, Alessio |e verfasserin |4 aut | |
| 700 | 1 | |a Verzoni, Elena |e verfasserin |4 aut | |
| 700 | 1 | |a Giusti, Raffaele |e verfasserin |4 aut | |
| 700 | 1 | |a Aprile, Giuseppe |e verfasserin |4 aut | |
| 700 | 1 | |a Ermacora, Paola |e verfasserin |4 aut | |
| 700 | 1 | |a Catino, Annamaria |e verfasserin |4 aut | |
| 700 | 1 | |a Pipitone, Stefania |e verfasserin |4 aut | |
| 700 | 1 | |a Di Napoli, Marilena |e verfasserin |4 aut | |
| 700 | 1 | |a Scotti, Vieri |e verfasserin |4 aut | |
| 700 | 1 | |a Mazzoni, Francesca |e verfasserin |4 aut | |
| 700 | 1 | |a Guglielmini, Pamela F |e verfasserin |4 aut | |
| 700 | 1 | |a Veccia, Antonello |e verfasserin |4 aut | |
| 700 | 1 | |a Maruzzo, Marco |e verfasserin |4 aut | |
| 700 | 1 | |a Schinzari, Giovanni |e verfasserin |4 aut | |
| 700 | 1 | |a Casadei, Chiara |e verfasserin |4 aut | |
| 700 | 1 | |a Grossi, Francesco |e verfasserin |4 aut | |
| 700 | 1 | |a Rizzo, Mimma |e verfasserin |4 aut | |
| 700 | 1 | |a Montesarchio, Vincenzo |e verfasserin |4 aut | |
| 700 | 1 | |a Verderame, Francesco |e verfasserin |4 aut | |
| 700 | 1 | |a Mencoboni, Manlio |e verfasserin |4 aut | |
| 700 | 1 | |a Zustovich, Fable |e verfasserin |4 aut | |
| 700 | 1 | |a Fratino, Lucia |e verfasserin |4 aut | |
| 700 | 1 | |a Accettura, Caterina |e verfasserin |4 aut | |
| 700 | 1 | |a Cinieri, Saverio |e verfasserin |4 aut | |
| 700 | 1 | |a Tondini, Carlo Alberto |e verfasserin |4 aut | |
| 700 | 1 | |a Camerini, Andrea |e verfasserin |4 aut | |
| 700 | 1 | |a Banzi, Maria Chiara |e verfasserin |4 aut | |
| 700 | 1 | |a Sorarù, Mariella |e verfasserin |4 aut | |
| 700 | 1 | |a Zucali, Paolo Andrea |e verfasserin |4 aut | |
| 700 | 1 | |a Vignani, Francesca |e verfasserin |4 aut | |
| 700 | 1 | |a Ricciardi, Serena |e verfasserin |4 aut | |
| 700 | 1 | |a Russo, Antonio |e verfasserin |4 aut | |
| 700 | 1 | |a Cosenza, Agnese |e verfasserin |4 aut | |
| 700 | 1 | |a Di Maio, Massimo |e verfasserin |4 aut | |
| 700 | 1 | |a De Giorgi, Ugo |e verfasserin |4 aut | |
| 700 | 1 | |a Pignata, Sandro |e verfasserin |4 aut | |
| 700 | 1 | |a Giannarelli, Diana |e verfasserin |4 aut | |
| 700 | 1 | |a Pinto, Carmine |e verfasserin |4 aut | |
| 700 | 1 | |a Buti, Sebastiano |e verfasserin |4 aut | |
| 700 | 1 | |a Fornarini, Giuseppe |e verfasserin |4 aut | |
| 700 | 1 | |a Rebuzzi, Sara Elena |e verfasserin |4 aut | |
| 700 | 1 | |a Rescigno, Pasquale |e verfasserin |4 aut | |
| 700 | 1 | |a Addeo, Alfredo |e verfasserin |4 aut | |
| 700 | 1 | |a Banna, Giuseppe L |e verfasserin |4 aut | |
| 700 | 1 | |a Bersanelli, Melissa |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t iScience |d 2018 |g 26(2023), 11 vom: 17. Nov., Seite 107970 |w (DE-627)NLM285332627 |x 2589-0042 |7 nnns |
| 773 | 1 | 8 | |g volume:26 |g year:2023 |g number:11 |g day:17 |g month:11 |g pages:107970 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.isci.2023.107970 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 26 |j 2023 |e 11 |b 17 |c 11 |h 107970 | ||