Effect of Nigella sativa Intake on Oxidative Stress and Inflammation in Patients with Metabolic Syndrome and Related Disorders : A Systematic Review and Meta-analysis of Randomized Controlled Trials
Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.net..
BACKGROUND: Several studies have shown that the intake of N. sativa has a beneficial effect on metabolic syndrome and related disorders. In this meta-analysis, our primary objective was to assess the impact of Nigella sativa consumption on inflammation and oxidative stress biomarkers among individuals diagnosed with metabolic syndrome and its associated conditions.
METHODS: Our search was conducted on prominent online databases such as Web of Science, Scopus, PubMed, and EMBASE, utilizing relevant keywords until August 2023.
RESULTS: This meta-analysis was performed on 16 RCTs comprising 1033 participants. Our results showed that intake of nigella sativa significantly decreased CRP [SMD: -0.60; (95% CI: from -0.96 to -0.23); P = 0.00], TNF-α [SMD: -0.53; (95% CI: from -0.74 to -0.53); P = 0.00]; IL-6 [SMD: -0.54 ; (95% CI: from -1.01 to -0.07); P = 0.02], and MDA: [SMD: -1.28; (95% CI: from -2.11 to -0.46); P = 0.00] levels. In addition, SOD: [SMD: 1.35; (95% CI, from 0.77 to 1.93); P = 0.00] and TAC [SMD: 2.82; (95% CI, from 0.55 to 5.084); P = 0.01] levels significantly increased in the intervention group compared to the placebo group.
CONCLUSION: Our results showed that THE consumption of N. sativa could be associated with improved oxidative stress and inflammation in patients with metabolic syndrome and related disorders.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2023 |
|---|---|
| Enthalten in: |
Current pharmaceutical biotechnology - (2023) vom: 05. Okt. |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Hosseini, Hossein [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Inflammation |
|---|
| Anmerkungen: |
Date Revised 20.10.2023 published: Print-Electronic Citation Status Publisher |
|---|
| doi: |
10.2174/0113892010266109230928000134 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM363517278 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM363517278 | ||
| 003 | DE-627 | ||
| 005 | 20231226093522.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.2174/0113892010266109230928000134 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1211.xml |
| 035 | |a (DE-627)NLM363517278 | ||
| 035 | |a (NLM)37859312 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Hosseini, Hossein |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Effect of Nigella sativa Intake on Oxidative Stress and Inflammation in Patients with Metabolic Syndrome and Related Disorders |b A Systematic Review and Meta-analysis of Randomized Controlled Trials |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Revised 20.10.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status Publisher | ||
| 520 | |a Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.net. | ||
| 520 | |a BACKGROUND: Several studies have shown that the intake of N. sativa has a beneficial effect on metabolic syndrome and related disorders. In this meta-analysis, our primary objective was to assess the impact of Nigella sativa consumption on inflammation and oxidative stress biomarkers among individuals diagnosed with metabolic syndrome and its associated conditions | ||
| 520 | |a METHODS: Our search was conducted on prominent online databases such as Web of Science, Scopus, PubMed, and EMBASE, utilizing relevant keywords until August 2023 | ||
| 520 | |a RESULTS: This meta-analysis was performed on 16 RCTs comprising 1033 participants. Our results showed that intake of nigella sativa significantly decreased CRP [SMD: -0.60; (95% CI: from -0.96 to -0.23); P = 0.00], TNF-α [SMD: -0.53; (95% CI: from -0.74 to -0.53); P = 0.00]; IL-6 [SMD: -0.54 ; (95% CI: from -1.01 to -0.07); P = 0.02], and MDA: [SMD: -1.28; (95% CI: from -2.11 to -0.46); P = 0.00] levels. In addition, SOD: [SMD: 1.35; (95% CI, from 0.77 to 1.93); P = 0.00] and TAC [SMD: 2.82; (95% CI, from 0.55 to 5.084); P = 0.01] levels significantly increased in the intervention group compared to the placebo group | ||
| 520 | |a CONCLUSION: Our results showed that THE consumption of N. sativa could be associated with improved oxidative stress and inflammation in patients with metabolic syndrome and related disorders | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Metabolic syndrome | |
| 650 | 4 | |a inflammation | |
| 650 | 4 | |a meta-analysis | |
| 650 | 4 | |a nigella sativa | |
| 650 | 4 | |a oxidative stress | |
| 650 | 4 | |a systematic review. | |
| 700 | 1 | |a Ghavidel, Farideh |e verfasserin |4 aut | |
| 700 | 1 | |a Aliyari, Mahdieh |e verfasserin |4 aut | |
| 700 | 1 | |a Hashemy, Seyed Isaac |e verfasserin |4 aut | |
| 700 | 1 | |a Jamialahmadi, Tannaz |e verfasserin |4 aut | |
| 700 | 1 | |a Sahebkar, Amirhossein |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Current pharmaceutical biotechnology |d 2000 |g (2023) vom: 05. Okt. |w (DE-627)NLM11369072X |x 1873-4316 |7 nnns |
| 773 | 1 | 8 | |g year:2023 |g day:05 |g month:10 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.2174/0113892010266109230928000134 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |j 2023 |b 05 |c 10 | ||