Frailty and associated outcomes in patients undergoing percutaneous left atrial appendage occlusion : findings from the NCDR LAAO registry
© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature..
BACKGROUND: Frailty is associated with significant morbidity and mortality and may have clinical implications in an advanced age population with atrial fibrillation undergoing left atrial appendage occlusion (LAAO). We sought to develop a novel frailty scale to predict worse outcomes in patients undergoing LAAO.
METHODS: Patients in the NCDR LAAO Registry between 2016 and 2021 receiving percutaneous LAAO devices were categorized as non-frail (0 points), pre-frail (1-3 points), or frail (4-5 points) based on a 5-point scale representing multiple domains of frailty: hemoglobin <13.0 g/dL in male, <12.0 g/dL in female; creatinine ≥1.2 mg/dL; albumin <3.5 g/dL; body mass index <20 kg/m2; and increased risk of falls.
RESULTS: Of 57,728 patients, 44,360 (76.8%) were pre-frail and 7693 (13.3%) were frail. Compared to non-frail, pre-frail and frail patients were older, had a higher burden of co-morbidities, and more disability based on the Modified Rankin Scale. Compared to non-frail patients after adjustment, frail patients were at higher risk of in-hospital major complication (OR 1.29, 95% 1.02-1.62, p = 0.01), any complication (OR 1.29, 95% CI 1.09-1.52, p = 0.0005), and death (OR 5.79, 95% CI 1.75-19.17, p = 0.001), while no difference was observed in pre-frail patients. At 45-day follow-up, there was no difference in the risk of complications in frail patients as compared to non-frail, although mortality was significantly higher (OR 3.01, 95% CI 1.97-4.85, p < 0.0001).
CONCLUSION: A simple and practical frailty scale accurately predicts adverse events in patients undergoing LAAO. The 13% of patients considered frail were at significantly higher risk of in-hospital adverse events and 45-day mortality.
| Errataetall: |
ErratumIn: J Interv Card Electrophysiol. 2023 Nov 29;:. - PMID 38019421 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:67 |
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| Enthalten in: |
Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing - 67(2024), 3 vom: 28. Apr., Seite 625-635 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Darden, Douglas [VerfasserIn] |
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| Links: |
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| Themen: |
Frailty |
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| Anmerkungen: |
Date Completed 15.04.2024 Date Revised 15.04.2024 published: Print-Electronic ErratumIn: J Interv Card Electrophysiol. 2023 Nov 29;:. - PMID 38019421 Citation Status MEDLINE |
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| doi: |
10.1007/s10840-023-01662-1 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM363504354 |
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| 245 | 1 | 0 | |a Frailty and associated outcomes in patients undergoing percutaneous left atrial appendage occlusion |b findings from the NCDR LAAO registry |
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| 500 | |a Date Revised 15.04.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a ErratumIn: J Interv Card Electrophysiol. 2023 Nov 29;:. - PMID 38019421 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. | ||
| 520 | |a BACKGROUND: Frailty is associated with significant morbidity and mortality and may have clinical implications in an advanced age population with atrial fibrillation undergoing left atrial appendage occlusion (LAAO). We sought to develop a novel frailty scale to predict worse outcomes in patients undergoing LAAO | ||
| 520 | |a METHODS: Patients in the NCDR LAAO Registry between 2016 and 2021 receiving percutaneous LAAO devices were categorized as non-frail (0 points), pre-frail (1-3 points), or frail (4-5 points) based on a 5-point scale representing multiple domains of frailty: hemoglobin <13.0 g/dL in male, <12.0 g/dL in female; creatinine ≥1.2 mg/dL; albumin <3.5 g/dL; body mass index <20 kg/m2; and increased risk of falls | ||
| 520 | |a RESULTS: Of 57,728 patients, 44,360 (76.8%) were pre-frail and 7693 (13.3%) were frail. Compared to non-frail, pre-frail and frail patients were older, had a higher burden of co-morbidities, and more disability based on the Modified Rankin Scale. Compared to non-frail patients after adjustment, frail patients were at higher risk of in-hospital major complication (OR 1.29, 95% 1.02-1.62, p = 0.01), any complication (OR 1.29, 95% CI 1.09-1.52, p = 0.0005), and death (OR 5.79, 95% CI 1.75-19.17, p = 0.001), while no difference was observed in pre-frail patients. At 45-day follow-up, there was no difference in the risk of complications in frail patients as compared to non-frail, although mortality was significantly higher (OR 3.01, 95% CI 1.97-4.85, p < 0.0001) | ||
| 520 | |a CONCLUSION: A simple and practical frailty scale accurately predicts adverse events in patients undergoing LAAO. The 13% of patients considered frail were at significantly higher risk of in-hospital adverse events and 45-day mortality | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Frailty | |
| 650 | 4 | |a Left atrial appendage occlusion | |
| 650 | 4 | |a Outcomes | |
| 650 | 4 | |a Registry | |
| 650 | 4 | |a Watchman | |
| 700 | 1 | |a Bilal Munir, M |e verfasserin |4 aut | |
| 700 | 1 | |a Zimmerman, Sarah |e verfasserin |4 aut | |
| 700 | 1 | |a Eskander, Michael |e verfasserin |4 aut | |
| 700 | 1 | |a Pothineni, Naga Venkata K |e verfasserin |4 aut | |
| 700 | 1 | |a Gopinathannair, Rakesh |e verfasserin |4 aut | |
| 700 | 1 | |a Kabra, Rajesh |e verfasserin |4 aut | |
| 700 | 1 | |a Lakkireddy, Dhanunjaya |e verfasserin |4 aut | |
| 700 | 1 | |a Duong, Thao |e verfasserin |4 aut | |
| 700 | 1 | |a Han, Frederick T |e verfasserin |4 aut | |
| 700 | 1 | |a Freeman, James V |e verfasserin |4 aut | |
| 700 | 1 | |a Hsu, Jonathan C |e verfasserin |4 aut | |
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