Syncytin-1, syncytin-2 and suppressyn in human health and disease
© 2023. The Author(s)..
In this review, we summarized the results of experimental and clinical studies about three human endogenous retroviruses and their products-syncytin-1, syncytin-2, and suppressyn in human physiology and pathophysiology. We summed up the described connection with various pathological processes and diseases, mainly with pregnancy-induced hypertensive diseases such as preeclampsia, oncogenesis, gestational trophoblastic disease, and multiple sclerosis. Supposed mechanisms of action and the potential of clinical applications are also described.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:101 |
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| Enthalten in: |
Journal of molecular medicine (Berlin, Germany) - 101(2023), 12 vom: 11. Dez., Seite 1527-1542 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Priščáková, Petra [VerfasserIn] |
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| Links: |
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| Themen: |
Gene Products, env |
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| Anmerkungen: |
Date Completed 06.12.2023 Date Revised 12.01.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s00109-023-02385-6 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM363483365 |
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| 520 | |a © 2023. The Author(s). | ||
| 520 | |a In this review, we summarized the results of experimental and clinical studies about three human endogenous retroviruses and their products-syncytin-1, syncytin-2, and suppressyn in human physiology and pathophysiology. We summed up the described connection with various pathological processes and diseases, mainly with pregnancy-induced hypertensive diseases such as preeclampsia, oncogenesis, gestational trophoblastic disease, and multiple sclerosis. Supposed mechanisms of action and the potential of clinical applications are also described | ||
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Gbelcová, Helena |e verfasserin |4 aut | |
| 700 | 1 | |a Gergely, Lajos |e verfasserin |4 aut | |
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