Functional and transcriptional heterogeneity within the massively expanding HLADR+CD38+ CD8 T cell population in acute febrile dengue patients
IMPORTANCE: CD8 T cells play a crucial role in protecting against intracellular pathogens such as viruses by eliminating infected cells and releasing anti-viral cytokines such as interferon gamma (IFNγ). Consequently, there is significant interest in comprehensively characterizing CD8 T cell responses in acute dengue febrile patients. Previous studies, including our own, have demonstrated that a discrete population of CD8 T cells with HLADR+ CD38+ phenotype undergoes massive expansion during the acute febrile phase of natural dengue virus infection. Although about a third of these massively expanding HLADR+ CD38+ CD8 T cells were also CD69high when examined ex vivo, only a small fraction of them produced IFNγ upon in vitro peptide stimulation. Therefore, to better understand such functional diversity of CD8 T cells responding to dengue virus infection, it is important to know the cytokines/chemokines expressed by these peptide-stimulated HLADR+CD38+ CD8 T cells and the transcriptional profiles that distinguish the CD69+IFNγ+, CD69+IFNγ-, and CD69-IFNγ- subsets.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:97 |
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| Enthalten in: |
Journal of virology - 97(2023), 11 vom: 30. Nov., Seite e0074623 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Singh, Prabhat [VerfasserIn] |
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| Links: |
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| Themen: |
82115-62-6 |
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| Anmerkungen: |
Date Completed 06.12.2023 Date Revised 06.12.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1128/jvi.00746-23 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM363480838 |
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| 100 | 1 | |a Singh, Prabhat |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Functional and transcriptional heterogeneity within the massively expanding HLADR+CD38+ CD8 T cell population in acute febrile dengue patients |
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| 520 | |a IMPORTANCE: CD8 T cells play a crucial role in protecting against intracellular pathogens such as viruses by eliminating infected cells and releasing anti-viral cytokines such as interferon gamma (IFNγ). Consequently, there is significant interest in comprehensively characterizing CD8 T cell responses in acute dengue febrile patients. Previous studies, including our own, have demonstrated that a discrete population of CD8 T cells with HLADR+ CD38+ phenotype undergoes massive expansion during the acute febrile phase of natural dengue virus infection. Although about a third of these massively expanding HLADR+ CD38+ CD8 T cells were also CD69high when examined ex vivo, only a small fraction of them produced IFNγ upon in vitro peptide stimulation. Therefore, to better understand such functional diversity of CD8 T cells responding to dengue virus infection, it is important to know the cytokines/chemokines expressed by these peptide-stimulated HLADR+CD38+ CD8 T cells and the transcriptional profiles that distinguish the CD69+IFNγ+, CD69+IFNγ-, and CD69-IFNγ- subsets | ||
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Chawla, Yadya M |e verfasserin |4 aut | |
| 700 | 1 | |a Saini, Keshav |e verfasserin |4 aut | |
| 700 | 1 | |a Reddy, Elluri Seetharami |e verfasserin |4 aut | |
| 700 | 1 | |a Gottimukkala, Kamalvishnu |e verfasserin |4 aut | |
| 700 | 1 | |a Nayak, Kaustuv |e verfasserin |4 aut | |
| 700 | 1 | |a Gunisetty, Sivaram |e verfasserin |4 aut | |
| 700 | 1 | |a Aggarwal, Charu |e verfasserin |4 aut | |
| 700 | 1 | |a Jain, Shweta |e verfasserin |4 aut | |
| 700 | 1 | |a Verma, Chaitanya |e verfasserin |4 aut | |
| 700 | 1 | |a Singla, Paras |e verfasserin |4 aut | |
| 700 | 1 | |a Soneja, Manish |e verfasserin |4 aut | |
| 700 | 1 | |a Wig, Naveet |e verfasserin |4 aut | |
| 700 | 1 | |a Murali-Krishna, Kaja |e verfasserin |4 aut | |
| 700 | 1 | |a Chandele, Anmol |e verfasserin |4 aut | |
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