Animal models in peripheral nerve transection studies : a systematic review on study design and outcomes assessment
Aim: Peripheral nerve injury regeneration studies using animal models are crucial to different pre-clinical therapeutic approaches efficacy evaluation whatever the surgical technique explored. Materials & methods: A 944 articles systematic review on 'peripheral nerve injury in animal models' over the last 9 years was carried out. Results: It was found that 91% used rodents, and only 9% employed large animals. Different nerves are studied, with generated gaps (10,78 mm) and methods applied for regeneration evaluation uniformed. Sciatic nerve was the most used (88%), followed by median and facial nerves (2.6%), significantly different. Conclusion: There has not been a significant scale-up of the in vivo testing to large animal models (anatomically/physiologically closer to humans), allowing an improvement in translational medicine for clinical cases.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:19 |
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| Enthalten in: |
Regenerative medicine - 19(2024), 4 vom: 18. März, Seite 189-203 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Lopes, Bruna [VerfasserIn] |
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| Links: |
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| Themen: |
Animal models |
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| Anmerkungen: |
Date Completed 28.03.2024 Date Revised 28.03.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.2217/rme-2023-0102 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM363476911 |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Aim: Peripheral nerve injury regeneration studies using animal models are crucial to different pre-clinical therapeutic approaches efficacy evaluation whatever the surgical technique explored. Materials & methods: A 944 articles systematic review on 'peripheral nerve injury in animal models' over the last 9 years was carried out. Results: It was found that 91% used rodents, and only 9% employed large animals. Different nerves are studied, with generated gaps (10,78 mm) and methods applied for regeneration evaluation uniformed. Sciatic nerve was the most used (88%), followed by median and facial nerves (2.6%), significantly different. Conclusion: There has not been a significant scale-up of the in vivo testing to large animal models (anatomically/physiologically closer to humans), allowing an improvement in translational medicine for clinical cases | ||
| 650 | 4 | |a Systematic Review | |
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| 650 | 4 | |a peripheral nerve regeneration | |
| 650 | 4 | |a translational medicine | |
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| 700 | 1 | |a Alvites, Rui |e verfasserin |4 aut | |
| 700 | 1 | |a Sousa, Ana Catarina |e verfasserin |4 aut | |
| 700 | 1 | |a Sousa, Patrícia |e verfasserin |4 aut | |
| 700 | 1 | |a Moreira, Alícia |e verfasserin |4 aut | |
| 700 | 1 | |a Atayde, Luís |e verfasserin |4 aut | |
| 700 | 1 | |a Salgado, António |e verfasserin |4 aut | |
| 700 | 1 | |a Geuna, Stefano |e verfasserin |4 aut | |
| 700 | 1 | |a Maurício, Ana Colette |e verfasserin |4 aut | |
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