Preliminary results in tracheal replacement using stented aortic matrices for primary extensive tracheal cancer
© 2023 The Author(s)..
Objective: Recent studies have demonstrated the feasibility and favorable long-term results of tracheobronchial replacement using stented cryopreserved aortic allografts. We propose to investigate the outcomes of this emerging technique in the subgroup of patients with extensive tracheal cancer.
Methods: This study was based on 13 patients with primary extensive tracheal cancer extracted from the prospective registry TRITON-01 (ClinicalTrials.gov Identifier: NCT04263129), which included 40 patients in total. We analyzed early and late outcomes in this subset of patients.
Results: From March 2019 to September 2022, 13 patients were included in the study. There were 9 female and 4 male patients, with a mean age of 53.9 years [36-71 years]. They had tracheal replacement for extended adenoid cystic carcinoma (n = 11), squamous cell carcinoma (n = 1), and mucoepidermoid carcinoma (n = 1). A venovenous extracorporeal membrane oxygenation was used in the 6 last cases. The mean length of resection was 81 mm [50-120 mm]. There was no 30-day postoperative mortality. A complete resection (R0) was achieved in 11 patients. The main late complications consisted of tracheal granulomas related to the stent and requiring repeated bronchoscopies (n = 9), pneumonia (n = 3), airway infection (n = 1), bronchoesophageal fistula (n = 1), mechanical stent obstruction requiring change (n = 2), and mediastinitis treated by antibiotics, drainage, and omentoplasty (n = 1). With a maximal follow-up of 3 years and 7 months, cancer recurrence was observed in 2 patients. All patients were alive at last follow-up except 2 (84.6%).
Conclusions: Airway replacement using stented CAA represents a feasible and promising solution for extensive tracheal cancer.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:21 |
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| Enthalten in: |
JTCVS techniques - 21(2023) vom: 30. Okt., Seite 227-236 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Onorati, Ilaria [VerfasserIn] |
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| Links: |
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| Themen: |
Adenoid cystic carcinoma |
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| Anmerkungen: |
Date Revised 20.10.2023 published: Electronic-eCollection ClinicalTrials.gov: NCT04263129 Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1016/j.xjtc.2023.05.021 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM363472932 |
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| 245 | 1 | 0 | |a Preliminary results in tracheal replacement using stented aortic matrices for primary extensive tracheal cancer |
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| 500 | |a published: Electronic-eCollection | ||
| 500 | |a ClinicalTrials.gov: NCT04263129 | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a © 2023 The Author(s). | ||
| 520 | |a Objective: Recent studies have demonstrated the feasibility and favorable long-term results of tracheobronchial replacement using stented cryopreserved aortic allografts. We propose to investigate the outcomes of this emerging technique in the subgroup of patients with extensive tracheal cancer | ||
| 520 | |a Methods: This study was based on 13 patients with primary extensive tracheal cancer extracted from the prospective registry TRITON-01 (ClinicalTrials.gov Identifier: NCT04263129), which included 40 patients in total. We analyzed early and late outcomes in this subset of patients | ||
| 520 | |a Results: From March 2019 to September 2022, 13 patients were included in the study. There were 9 female and 4 male patients, with a mean age of 53.9 years [36-71 years]. They had tracheal replacement for extended adenoid cystic carcinoma (n = 11), squamous cell carcinoma (n = 1), and mucoepidermoid carcinoma (n = 1). A venovenous extracorporeal membrane oxygenation was used in the 6 last cases. The mean length of resection was 81 mm [50-120 mm]. There was no 30-day postoperative mortality. A complete resection (R0) was achieved in 11 patients. The main late complications consisted of tracheal granulomas related to the stent and requiring repeated bronchoscopies (n = 9), pneumonia (n = 3), airway infection (n = 1), bronchoesophageal fistula (n = 1), mechanical stent obstruction requiring change (n = 2), and mediastinitis treated by antibiotics, drainage, and omentoplasty (n = 1). With a maximal follow-up of 3 years and 7 months, cancer recurrence was observed in 2 patients. All patients were alive at last follow-up except 2 (84.6%) | ||
| 520 | |a Conclusions: Airway replacement using stented CAA represents a feasible and promising solution for extensive tracheal cancer | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a adenoid cystic carcinoma | |
| 650 | 4 | |a aortic allograft | |
| 650 | 4 | |a extensive tracheal cancer | |
| 650 | 4 | |a squamous cell carcinoma | |
| 650 | 4 | |a tracheal replacement | |
| 700 | 1 | |a Radu, Dana M |e verfasserin |4 aut | |
| 700 | 1 | |a Portela, Ana Maria Santos |e verfasserin |4 aut | |
| 700 | 1 | |a Peretti, Marine |e verfasserin |4 aut | |
| 700 | 1 | |a Guiraudet, Patrice |e verfasserin |4 aut | |
| 700 | 1 | |a Bardet, Jeremy |e verfasserin |4 aut | |
| 700 | 1 | |a Freynet, Olivia |e verfasserin |4 aut | |
| 700 | 1 | |a Didier, Morgane |e verfasserin |4 aut | |
| 700 | 1 | |a Uzunhan, Yurdagül |e verfasserin |4 aut | |
| 700 | 1 | |a Chouahnia, Kader |e verfasserin |4 aut | |
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| 700 | 1 | |a Tronc, François |e verfasserin |4 aut | |
| 700 | 1 | |a Sanchez, Myriam Locatelli |e verfasserin |4 aut | |
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| 700 | 1 | |a Martinod, Emmanuel |e verfasserin |4 aut | |
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