Surveillance for rat hepatitis E in wastewater networks, Italy
IMPORTANCE: Hepatitis E virus (HEV) infection constitutes a significant health problem worldwide. In recent years, in addition to the zoonotic HEV3 and HEV4, emerging highly divergent hepevirus of rat origin (rat HEV [RHEV]) has been associated with human acute and chronic hepatitis. As environmental surveillance can be a complementary tool to explore emerging viruses of human and rodent origin, we investigated the epidemiology and the genetic variability of RHEV targeting 14 wastewater treatment plants in an Italian geographic area considered a hot spot for HEV infection in humans. Our results revealed that RHEV is a significant component of the wastewater microbiota with viral RNA detected in 43.9% of the specimens tested, adding further evidence to the need to investigate more in depth the real burden of RHEV infections in humans.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:11 |
|---|---|
| Enthalten in: |
Microbiology spectrum - 11(2023), 6 vom: 12. Dez., Seite e0267523 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Palombieri, Andrea [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Italy |
|---|
| Anmerkungen: |
Date Completed 16.12.2023 Date Revised 16.12.2023 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1128/spectrum.02675-23 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM363433201 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM363433201 | ||
| 003 | DE-627 | ||
| 005 | 20231227133059.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1128/spectrum.02675-23 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1230.xml |
| 035 | |a (DE-627)NLM363433201 | ||
| 035 | |a (NLM)37850788 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Palombieri, Andrea |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Surveillance for rat hepatitis E in wastewater networks, Italy |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 16.12.2023 | ||
| 500 | |a Date Revised 16.12.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a IMPORTANCE: Hepatitis E virus (HEV) infection constitutes a significant health problem worldwide. In recent years, in addition to the zoonotic HEV3 and HEV4, emerging highly divergent hepevirus of rat origin (rat HEV [RHEV]) has been associated with human acute and chronic hepatitis. As environmental surveillance can be a complementary tool to explore emerging viruses of human and rodent origin, we investigated the epidemiology and the genetic variability of RHEV targeting 14 wastewater treatment plants in an Italian geographic area considered a hot spot for HEV infection in humans. Our results revealed that RHEV is a significant component of the wastewater microbiota with viral RNA detected in 43.9% of the specimens tested, adding further evidence to the need to investigate more in depth the real burden of RHEV infections in humans | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Italy | |
| 650 | 4 | |a rat hepatitis E virus | |
| 650 | 4 | |a viruses | |
| 650 | 4 | |a wastewater surveillance | |
| 650 | 4 | |a zoonoses | |
| 650 | 7 | |a Wastewater |2 NLM | |
| 700 | 1 | |a Di Profio, Federica |e verfasserin |4 aut | |
| 700 | 1 | |a Sarchese, Vittorio |e verfasserin |4 aut | |
| 700 | 1 | |a Fruci, Paola |e verfasserin |4 aut | |
| 700 | 1 | |a Suffredini, Elisabetta |e verfasserin |4 aut | |
| 700 | 1 | |a Martella, Vito |e verfasserin |4 aut | |
| 700 | 1 | |a Veneri, Carolina |e verfasserin |4 aut | |
| 700 | 1 | |a Bonanno Ferraro, Giusy |e verfasserin |4 aut | |
| 700 | 1 | |a Mancini, Pamela |e verfasserin |4 aut | |
| 700 | 1 | |a La Rosa, Giuseppina |e verfasserin |4 aut | |
| 700 | 1 | |a Di Martino, Barbara |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Microbiology spectrum |d 2013 |g 11(2023), 6 vom: 12. Dez., Seite e0267523 |w (DE-627)NLM241847044 |x 2165-0497 |7 nnns |
| 773 | 1 | 8 | |g volume:11 |g year:2023 |g number:6 |g day:12 |g month:12 |g pages:e0267523 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1128/spectrum.02675-23 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 11 |j 2023 |e 6 |b 12 |c 12 |h e0267523 | ||