Two-phase Bayesian latent class analysis to assess diagnostic test performance in the absence of a gold standard : COVID-19 serological assays as a proof of concept
© 2023 International Society of Blood Transfusion..
BACKGROUND AND OBJECTIVES: In this proof-of-concept study, which included blood donor samples, we aimed to demonstrate how Bayesian latent class models (BLCMs) could be used to estimate SARS-CoV-2 seroprevalence in the absence of a gold standard assay under a two-phase sampling design.
MATERIALS AND METHODS: To this end, 6810 plasma samples from blood donors who resided in Québec (Canada) were collected from May to July 2020 and tested for anti-SARS-CoV-2 antibodies using seven serological assays (five commercial and two non-commercial).
RESULTS: SARS-CoV-2 seroprevalence was estimated at 0.71% (95% credible interval [CrI] = 0.53%-0.92%). The cPass assay had the lowest sensitivity estimate (88.7%; 95% CrI = 80.6%-94.7%), while the Héma-Québec assay had the highest (98.7%; 95% CrI = 97.0%-99.6%).
CONCLUSION: The estimated low seroprevalence (which indicates a relatively limited spread of SARS-CoV-2 in Quebec) might change rapidly-and this tool, developed using blood donors, could enable a rapid update of the prevalence estimate in the absence of a gold standard. Further, the present analysis illustrates how a two-stage BLCM sampling design, along with blood donor samples, can be used to estimate the performance of new diagnostic tests and inform public health decisions regarding a new or emerging disease for which a perfect reference standard does not exist.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2023 |
---|---|
Erschienen: |
2023 |
Enthalten in: |
Zur Gesamtaufnahme - volume:118 |
---|---|
Enthalten in: |
Vox sanguinis - 118(2023), 12 vom: 06. Dez., Seite 1069-1077 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Camirand Lemyre, Felix [VerfasserIn] |
---|
Links: |
---|
Themen: |
Antibodies, Viral |
---|
Anmerkungen: |
Date Completed 16.12.2023 Date Revised 16.12.2023 published: Print-Electronic Citation Status MEDLINE |
---|
doi: |
10.1111/vox.13545 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM363428151 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | NLM363428151 | ||
003 | DE-627 | ||
005 | 20231227133059.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231226s2023 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1111/vox.13545 |2 doi | |
028 | 5 | 2 | |a pubmed24n1230.xml |
035 | |a (DE-627)NLM363428151 | ||
035 | |a (NLM)37850270 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Camirand Lemyre, Felix |e verfasserin |4 aut | |
245 | 1 | 0 | |a Two-phase Bayesian latent class analysis to assess diagnostic test performance in the absence of a gold standard |b COVID-19 serological assays as a proof of concept |
264 | 1 | |c 2023 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 16.12.2023 | ||
500 | |a Date Revised 16.12.2023 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a © 2023 International Society of Blood Transfusion. | ||
520 | |a BACKGROUND AND OBJECTIVES: In this proof-of-concept study, which included blood donor samples, we aimed to demonstrate how Bayesian latent class models (BLCMs) could be used to estimate SARS-CoV-2 seroprevalence in the absence of a gold standard assay under a two-phase sampling design | ||
520 | |a MATERIALS AND METHODS: To this end, 6810 plasma samples from blood donors who resided in Québec (Canada) were collected from May to July 2020 and tested for anti-SARS-CoV-2 antibodies using seven serological assays (five commercial and two non-commercial) | ||
520 | |a RESULTS: SARS-CoV-2 seroprevalence was estimated at 0.71% (95% credible interval [CrI] = 0.53%-0.92%). The cPass assay had the lowest sensitivity estimate (88.7%; 95% CrI = 80.6%-94.7%), while the Héma-Québec assay had the highest (98.7%; 95% CrI = 97.0%-99.6%) | ||
520 | |a CONCLUSION: The estimated low seroprevalence (which indicates a relatively limited spread of SARS-CoV-2 in Quebec) might change rapidly-and this tool, developed using blood donors, could enable a rapid update of the prevalence estimate in the absence of a gold standard. Further, the present analysis illustrates how a two-stage BLCM sampling design, along with blood donor samples, can be used to estimate the performance of new diagnostic tests and inform public health decisions regarding a new or emerging disease for which a perfect reference standard does not exist | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Bayesian latent class analysis | |
650 | 4 | |a COVID-19 serological testing | |
650 | 4 | |a SARS-CoV-2 | |
650 | 4 | |a blood donors | |
650 | 4 | |a diagnostic accuracy | |
650 | 4 | |a seroprevalence | |
650 | 7 | |a Antibodies, Viral |2 NLM | |
700 | 1 | |a Honfo, Sewanou Hermann |e verfasserin |4 aut | |
700 | 1 | |a Caya, Chelsea |e verfasserin |4 aut | |
700 | 1 | |a Cheng, Matthew P |e verfasserin |4 aut | |
700 | 1 | |a Colwill, Karen |e verfasserin |4 aut | |
700 | 1 | |a Corsini, Rachel |e verfasserin |4 aut | |
700 | 1 | |a Gingras, Anne-Claude |e verfasserin |4 aut | |
700 | 1 | |a Jassem, Agatha |e verfasserin |4 aut | |
700 | 1 | |a Krajden, Mel |e verfasserin |4 aut | |
700 | 1 | |a Márquez, Ana Citlali |e verfasserin |4 aut | |
700 | 1 | |a Mazer, Bruce D |e verfasserin |4 aut | |
700 | 1 | |a McLennan, Meghan |e verfasserin |4 aut | |
700 | 1 | |a Renaud, Christian |e verfasserin |4 aut | |
700 | 1 | |a Yansouni, Cedric P |e verfasserin |4 aut | |
700 | 1 | |a Papenburg, Jesse |e verfasserin |4 aut | |
700 | 1 | |a Lewin, Antoine |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Vox sanguinis |d 1952 |g 118(2023), 12 vom: 06. Dez., Seite 1069-1077 |w (DE-627)NLM000095028 |x 1423-0410 |7 nnns |
773 | 1 | 8 | |g volume:118 |g year:2023 |g number:12 |g day:06 |g month:12 |g pages:1069-1077 |
856 | 4 | 0 | |u http://dx.doi.org/10.1111/vox.13545 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 118 |j 2023 |e 12 |b 06 |c 12 |h 1069-1077 |