The Predictive Validity of the Berlin Definition of Acute Respiratory Distress Syndrome for Patients With COVID-19-Related Respiratory Failure Treated With High-Flow Nasal Oxygen : A Multicenter, Prospective Cohort Study
Copyright © 2023 by the Society of Critical Care Medicine and Wolters Kluwer Health, Inc. All Rights Reserved..
OBJECTIVES: The Berlin definition of acute respiratory distress syndrome (ARDS) was constructed for patients receiving invasive mechanical ventilation (IMV) with consideration given to issues related to reliability, feasibility, and validity. Notwithstanding, patients with acute respiratory failure (ARF) may be treated with high-flow nasal oxygen (HFNO) and may not fall within the scope of the original definition. We aimed to evaluate the predictive validity of the Berlin definition in HFNO-treated patients with COVID-19-related respiratory failure who otherwise met ARDS criteria.
DESIGN: Multicenter, prospective cohort study.
SETTING: Five ICUs of five centers in Argentina from March 2020 to September 2021.
PATIENTS: We consecutively included HFNO-treated patients older than 18 years with confirmed COVID-19-related ARF, a Pa o2 /F io2 of less than 300 mm Hg, bilateral infiltrates on imaging, and worsening respiratory symptoms for less than 1 week.
INTERVENTIONS: None.
MEASUREMENTS AND MAIN RESULTS: We evaluated the predictive validity of mortality at day 28 using the area under the receiver operating characteristics curve (AUC), compared the predictive validity across subgroups, and characterized relevant clinical outcomes. We screened 1,231 patients and included 696 ARDS patients [30 (4%) mild, 380 (55%) moderate, and 286 (41%) severe]. For the study cohort, the AUC for mortality at day 28 was 0.606 (95% CI, 0.561-0.651) with the AUC for subgroups being similar to that of the overall cohort. Two hundred fifty-six patients (37%) received IMV. By day 28, 142 patients (21%) had died, of whom 81 (57%) had severe ARDS. Mortality occurred primarily in patients who were transitioned to IMV.
CONCLUSIONS: The predictive validity of the Berlin ARDS definition was similar for HFNO-treated patients as compared with the original population of invasively ventilated patients. Our findings support the extension of the Berlin definition to HFNO-treated patients with ARDS.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:52 |
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| Enthalten in: |
Critical care medicine - 52(2024), 1 vom: 01. Jan., Seite 92-101 |
| Sprache: |
Englisch |
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| Anmerkungen: |
Date Completed 16.12.2023 Date Revised 06.02.2024 published: Print-Electronic ClinicalTrials.gov: NCT05178212 Citation Status MEDLINE |
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| doi: |
10.1097/CCM.0000000000006056 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 245 | 1 | 4 | |a The Predictive Validity of the Berlin Definition of Acute Respiratory Distress Syndrome for Patients With COVID-19-Related Respiratory Failure Treated With High-Flow Nasal Oxygen |b A Multicenter, Prospective Cohort Study |
| 264 | 1 | |c 2024 | |
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| 500 | |a Date Completed 16.12.2023 | ||
| 500 | |a Date Revised 06.02.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a ClinicalTrials.gov: NCT05178212 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2023 by the Society of Critical Care Medicine and Wolters Kluwer Health, Inc. All Rights Reserved. | ||
| 520 | |a OBJECTIVES: The Berlin definition of acute respiratory distress syndrome (ARDS) was constructed for patients receiving invasive mechanical ventilation (IMV) with consideration given to issues related to reliability, feasibility, and validity. Notwithstanding, patients with acute respiratory failure (ARF) may be treated with high-flow nasal oxygen (HFNO) and may not fall within the scope of the original definition. We aimed to evaluate the predictive validity of the Berlin definition in HFNO-treated patients with COVID-19-related respiratory failure who otherwise met ARDS criteria | ||
| 520 | |a DESIGN: Multicenter, prospective cohort study | ||
| 520 | |a SETTING: Five ICUs of five centers in Argentina from March 2020 to September 2021 | ||
| 520 | |a PATIENTS: We consecutively included HFNO-treated patients older than 18 years with confirmed COVID-19-related ARF, a Pa o2 /F io2 of less than 300 mm Hg, bilateral infiltrates on imaging, and worsening respiratory symptoms for less than 1 week | ||
| 520 | |a INTERVENTIONS: None | ||
| 520 | |a MEASUREMENTS AND MAIN RESULTS: We evaluated the predictive validity of mortality at day 28 using the area under the receiver operating characteristics curve (AUC), compared the predictive validity across subgroups, and characterized relevant clinical outcomes. We screened 1,231 patients and included 696 ARDS patients [30 (4%) mild, 380 (55%) moderate, and 286 (41%) severe]. For the study cohort, the AUC for mortality at day 28 was 0.606 (95% CI, 0.561-0.651) with the AUC for subgroups being similar to that of the overall cohort. Two hundred fifty-six patients (37%) received IMV. By day 28, 142 patients (21%) had died, of whom 81 (57%) had severe ARDS. Mortality occurred primarily in patients who were transitioned to IMV | ||
| 520 | |a CONCLUSIONS: The predictive validity of the Berlin ARDS definition was similar for HFNO-treated patients as compared with the original population of invasively ventilated patients. Our findings support the extension of the Berlin definition to HFNO-treated patients with ARDS | ||
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| 700 | 1 | |a Quintana, Jorgelina |e verfasserin |4 aut | |
| 700 | 1 | |a Olmos, Matias |e verfasserin |4 aut | |
| 700 | 1 | |a Burns, Karen E A |e verfasserin |4 aut | |
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| 700 | 1 | |a Saavedra, Santiago Nicolas |e investigator |4 oth | |
| 700 | 1 | |a Matarrese, Agustin |e investigator |4 oth | |
| 700 | 1 | |a Wasinger, Elizabeth Gisele |e investigator |4 oth | |
| 700 | 1 | |a Andrada, Facundo Juan |e investigator |4 oth | |
| 700 | 1 | |a Mast, Giuliana |e investigator |4 oth | |
| 700 | 1 | |a Kakisu, Hiromi |e investigator |4 oth | |
| 700 | 1 | |a Moreno, Claudia Navarro |e investigator |4 oth | |
| 700 | 1 | |a Barbaresi, Veronica |e investigator |4 oth | |
| 700 | 1 | |a Tirado, Anabel Miranda |e investigator |4 oth | |
| 700 | 1 | |a Pintos, Juan Manuel |e investigator |4 oth | |
| 700 | 1 | |a Viñas, María Constanza |e investigator |4 oth | |
| 700 | 1 | |a Gonzalez, Maria Eugenia |e investigator |4 oth | |
| 700 | 1 | |a Mateos, Maite |e investigator |4 oth | |
| 700 | 1 | |a Lagazio, Ana Inés |e investigator |4 oth | |
| 700 | 1 | |a Mogaadouro, Mariela Adriana |e investigator |4 oth | |
| 700 | 1 | |a Seifert, Micaela Ruiz |e investigator |4 oth | |
| 700 | 1 | |a Mastroberti, Emilce |e investigator |4 oth | |
| 700 | 1 | |a Romano, Nahuel Esteban |e investigator |4 oth | |
| 700 | 1 | |a Laiz, Marisol Mariela |e investigator |4 oth | |
| 700 | 1 | |a Urrutia, Jose Garcia |e investigator |4 oth | |
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