Probiotic Lactobacillus and the potential risk of spreading antibiotic resistance : a systematic review
Copyright: © 2023 Research in Pharmaceutical Sciences..
Background and purpose: Lactobacillus, the most popular probiotic, has recently gained more attention because it is a potential reservoir of antibiotic resistance. This review summarized and discussed the phenotypic-genotypic characteristics of antibiotic resistance.
Experimental approach: Google Scholar, PubMed, Web of Science, and Scopus were searched up to February 2022. The inclusion criteria were all studies testing antibiotic resistance of probiotic Lactobacillus strains present in human food supplementation and all human/animal model studies in which transferring antibiotic-resistant genes from Lactobacillus strains to another bacterium were investigated.
Findings/Results: Phenotypic and genotypic characterization of Lactobacillus probiotics showed that the most antibiotic resistance was against protein synthesis inhibitors (fourteen studies, 87.5%) and cell wall synthesis inhibitors (ten studies, 62.5%). Nine of these studies reported the transfer of antibiotic resistance from Lactobacillus probiotic as donor species to pathogenic bacteria and mostly used in vitro methods for resistance gene transfer.
Conclusion and implications: The transferability of resistance genes such as tet and erm in Lactobacillus increases the risk of spreading antibiotic resistance. Further studies need to be conducted to evaluate the potential spread of antibiotic resistance traits via probiotics, especially in elderly people and newborns.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:18 |
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| Enthalten in: |
Research in pharmaceutical sciences - 18(2023), 5 vom: 25. Sept., Seite 468-477 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Shahali, Ali [VerfasserIn] |
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| Links: |
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| Themen: |
Antibiotic resistance |
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| Anmerkungen: |
Date Revised 20.10.2023 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.4103/1735-5362.383703 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM363353380 |
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| 245 | 1 | 0 | |a Probiotic Lactobacillus and the potential risk of spreading antibiotic resistance |b a systematic review |
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| 500 | |a published: Electronic-eCollection | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a Copyright: © 2023 Research in Pharmaceutical Sciences. | ||
| 520 | |a Background and purpose: Lactobacillus, the most popular probiotic, has recently gained more attention because it is a potential reservoir of antibiotic resistance. This review summarized and discussed the phenotypic-genotypic characteristics of antibiotic resistance | ||
| 520 | |a Experimental approach: Google Scholar, PubMed, Web of Science, and Scopus were searched up to February 2022. The inclusion criteria were all studies testing antibiotic resistance of probiotic Lactobacillus strains present in human food supplementation and all human/animal model studies in which transferring antibiotic-resistant genes from Lactobacillus strains to another bacterium were investigated | ||
| 520 | |a Findings/Results: Phenotypic and genotypic characterization of Lactobacillus probiotics showed that the most antibiotic resistance was against protein synthesis inhibitors (fourteen studies, 87.5%) and cell wall synthesis inhibitors (ten studies, 62.5%). Nine of these studies reported the transfer of antibiotic resistance from Lactobacillus probiotic as donor species to pathogenic bacteria and mostly used in vitro methods for resistance gene transfer | ||
| 520 | |a Conclusion and implications: The transferability of resistance genes such as tet and erm in Lactobacillus increases the risk of spreading antibiotic resistance. Further studies need to be conducted to evaluate the potential spread of antibiotic resistance traits via probiotics, especially in elderly people and newborns | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Antibiotic resistance | |
| 650 | 4 | |a Lactobacillus probiotic | |
| 650 | 4 | |a Probiotic safety | |
| 650 | 4 | |a Systematic review | |
| 700 | 1 | |a Soltani, Rasool |e verfasserin |4 aut | |
| 700 | 1 | |a Akbari, Vajihe |e verfasserin |4 aut | |
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