Is high sensitivity troponin, taken regardless of a clinical indication, associated with 1 year mortality in critical care patients?
© The Intensive Care Society 2023..
The aim of this study was to assess whether high sensitivity troponin (hs-cTnI) is associated with 1 year mortality in critical care (CC). One year mortality data were obtained from NHS Digital for a consecutive cohort of patients admitted to general CC unit (GCCU) and neuroscience CC unit (NCCU) who had hs-cTnI tests performed throughout their CC admission, regardless of whether the test was clinically indicated. Cox proportional hazards were used to estimate the risk of 1-year mortality. A landmark analysis was undertaken to assess whether any relationship at 1 year was driven by mortality within the first 30 days. A total of 1033 consecutive patients were included. At 1 year 254 (24.6%) patients had died. The admission log(10)hs-cTnI concentration in the entire cohort (HR 1.35 (95% CI 1.05-1.75) p = 0.009 with a bootstrap of 1000 samples) was independently associated with 1 year mortality. On landmark analysis the association with 1 year mortality was driven by 30 day mortality. These results indicate that admission hs-cTnI concentration is independently associated with 1 year mortality in CC and this relationship may be driven by differences in mortality at 30 days.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:24 |
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| Enthalten in: |
Journal of the Intensive Care Society - 24(2023), 4 vom: 29. Nov., Seite 392-398 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Hinton, Jonathan [VerfasserIn] |
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| Links: |
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| Themen: |
Critical care |
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| Anmerkungen: |
Date Revised 20.10.2023 published: Print-Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1177/17511437231160078 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM363341080 |
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| 520 | |a © The Intensive Care Society 2023. | ||
| 520 | |a The aim of this study was to assess whether high sensitivity troponin (hs-cTnI) is associated with 1 year mortality in critical care (CC). One year mortality data were obtained from NHS Digital for a consecutive cohort of patients admitted to general CC unit (GCCU) and neuroscience CC unit (NCCU) who had hs-cTnI tests performed throughout their CC admission, regardless of whether the test was clinically indicated. Cox proportional hazards were used to estimate the risk of 1-year mortality. A landmark analysis was undertaken to assess whether any relationship at 1 year was driven by mortality within the first 30 days. A total of 1033 consecutive patients were included. At 1 year 254 (24.6%) patients had died. The admission log(10)hs-cTnI concentration in the entire cohort (HR 1.35 (95% CI 1.05-1.75) p = 0.009 with a bootstrap of 1000 samples) was independently associated with 1 year mortality. On landmark analysis the association with 1 year mortality was driven by 30 day mortality. These results indicate that admission hs-cTnI concentration is independently associated with 1 year mortality in CC and this relationship may be driven by differences in mortality at 30 days | ||
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Mariathas, Mark |e verfasserin |4 aut | |
| 700 | 1 | |a Allan, Rick |e verfasserin |4 aut | |
| 700 | 1 | |a Borca, Florina |e verfasserin |4 aut | |
| 700 | 1 | |a Nicholas, Zoe |e verfasserin |4 aut | |
| 700 | 1 | |a Gillett, Neil |e verfasserin |4 aut | |
| 700 | 1 | |a Kwok, Chun Shing |e verfasserin |4 aut | |
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| 700 | 1 | |a Curzen, Nick |e verfasserin |4 aut | |
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