Interfacing neural cells with typical microelectronics materials for future manufacturing
Copyright © 2023 Elsevier B.V. All rights reserved..
The biocompatibility of materials used in electronic devices is critical for the development of implantable devices like pacemakers and neuroprosthetics, as well as in future biomanufacturing. Biocompatibility refers to the ability of these materials to interact with living cells and tissues without causing an adverse response. Therefore, it is essential to evaluate the biocompatibility of metals and semiconductor materials used in electronic devices to ensure their safe use in medical applications. Here, we evaluated the biocompatibility of a collection of diced silicon chips coated with a variety of metal thin films, interfacing them with different cell types, including murine mastocytoma cells in suspension culture, adherent NIH 3T3 fibroblasts, and human induced pluripotent stem cell (iPSC)-derived neural progenitor cells (NPCs). All materials tested were biocompatible and showed the potential to support neural differentiation of iPSC-NPCs, creating an opportunity to use these materials in a scalable production of a range of biohybrid devices such as electronic devices to study neural behaviors and neuropathies.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:242 |
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| Enthalten in: |
Biosensors & bioelectronics - 242(2023) vom: 15. Dez., Seite 115749 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Pesantez Torres, Fernando [VerfasserIn] |
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| Links: |
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| Themen: |
Biocompatibility |
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| Anmerkungen: |
Date Completed 30.10.2023 Date Revised 30.10.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.bios.2023.115749 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Copyright © 2023 Elsevier B.V. All rights reserved. | ||
| 520 | |a The biocompatibility of materials used in electronic devices is critical for the development of implantable devices like pacemakers and neuroprosthetics, as well as in future biomanufacturing. Biocompatibility refers to the ability of these materials to interact with living cells and tissues without causing an adverse response. Therefore, it is essential to evaluate the biocompatibility of metals and semiconductor materials used in electronic devices to ensure their safe use in medical applications. Here, we evaluated the biocompatibility of a collection of diced silicon chips coated with a variety of metal thin films, interfacing them with different cell types, including murine mastocytoma cells in suspension culture, adherent NIH 3T3 fibroblasts, and human induced pluripotent stem cell (iPSC)-derived neural progenitor cells (NPCs). All materials tested were biocompatible and showed the potential to support neural differentiation of iPSC-NPCs, creating an opportunity to use these materials in a scalable production of a range of biohybrid devices such as electronic devices to study neural behaviors and neuropathies | ||
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| 650 | 4 | |a Metal-cell interaction | |
| 650 | 4 | |a Neural cells | |
| 650 | 4 | |a Pluripotent stem cells | |
| 650 | 4 | |a Semiconductor materials | |
| 700 | 1 | |a Tokranova, Natalya |e verfasserin |4 aut | |
| 700 | 1 | |a Amodeo, Eleanor |e verfasserin |4 aut | |
| 700 | 1 | |a Bertucci, Taylor |e verfasserin |4 aut | |
| 700 | 1 | |a Kiehl, Thomas R |e verfasserin |4 aut | |
| 700 | 1 | |a Xie, Yubing |e verfasserin |4 aut | |
| 700 | 1 | |a Cady, Nathaniel C |e verfasserin |4 aut | |
| 700 | 1 | |a Sharfstein, Susan T |e verfasserin |4 aut | |
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