Skin sympathetic nerve activity in different ablation settings for atrial fibrillation
Copyright © 2023 Elsevier Ltd. All rights reserved..
BACKGROUND: Modifying the autonomic system after catheter ablation may prevent the recurrence of atrial fibrillation (AF). Evaluation of skin sympathetic nerve activity (SKNA) is a noninvasive method for the assessment of sympathetic activity. However, there are few studies on the effects of different energy settings on SKNA.
OBJECTIVE: To investigate the changes in SKNA in different energy settings and their relationship to AF ablation outcomes.
METHODS: Seventy-two patients with paroxysmal and persistent AF were enrolled. Forty-three patients received AF ablation with the conventional (ConV) energy setting (low power for long duration), and 29 patients using a high-power, short-duration (HPSD) strategy. The SKNA was acquired from the right arm 1 day before and after the radiofrequency ablation. We analyzed the SKNA and ablation outcomes in the different energy settings.
RESULTS: Both groups had a similar baseline average SKNA (aSKNA). We found that the median aSKNA increased significantly from 446.82 μV to 805.93 μV (p = 0.003) in the ConV group but not in the HPSD group. In the ConV group, patients without AF recurrence had higher aSKNA values. However, the 1-year AF recurrence rate remained similar between both groups (35 % vs. 28 %, p = 0.52).
CONCLUSION: The post-ablation aSKNA levels increased significantly in the ConV group but did not change significantly in the HPSD group, which may reflect different neuromodulatory effects. However, the one-year AF recurrence rates were similar for both groups. These results demonstrate that the HPSD strategy has durable lesion creation but less lesion depth, which may reduce collateral damage.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:83 |
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| Enthalten in: |
Journal of cardiology - 83(2024), 5 vom: 25. Apr., Seite 306-312 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Weng, Chi-Jen [VerfasserIn] |
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| Links: |
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| Themen: |
Atrial fibrillation |
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| Anmerkungen: |
Date Completed 08.04.2024 Date Revised 08.04.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.jjcc.2023.10.004 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM363312951 |
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| 100 | 1 | |a Weng, Chi-Jen |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Skin sympathetic nerve activity in different ablation settings for atrial fibrillation |
| 264 | 1 | |c 2024 | |
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| 500 | |a Date Revised 08.04.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2023 Elsevier Ltd. All rights reserved. | ||
| 520 | |a BACKGROUND: Modifying the autonomic system after catheter ablation may prevent the recurrence of atrial fibrillation (AF). Evaluation of skin sympathetic nerve activity (SKNA) is a noninvasive method for the assessment of sympathetic activity. However, there are few studies on the effects of different energy settings on SKNA | ||
| 520 | |a OBJECTIVE: To investigate the changes in SKNA in different energy settings and their relationship to AF ablation outcomes | ||
| 520 | |a METHODS: Seventy-two patients with paroxysmal and persistent AF were enrolled. Forty-three patients received AF ablation with the conventional (ConV) energy setting (low power for long duration), and 29 patients using a high-power, short-duration (HPSD) strategy. The SKNA was acquired from the right arm 1 day before and after the radiofrequency ablation. We analyzed the SKNA and ablation outcomes in the different energy settings | ||
| 520 | |a RESULTS: Both groups had a similar baseline average SKNA (aSKNA). We found that the median aSKNA increased significantly from 446.82 μV to 805.93 μV (p = 0.003) in the ConV group but not in the HPSD group. In the ConV group, patients without AF recurrence had higher aSKNA values. However, the 1-year AF recurrence rate remained similar between both groups (35 % vs. 28 %, p = 0.52) | ||
| 520 | |a CONCLUSION: The post-ablation aSKNA levels increased significantly in the ConV group but did not change significantly in the HPSD group, which may reflect different neuromodulatory effects. However, the one-year AF recurrence rates were similar for both groups. These results demonstrate that the HPSD strategy has durable lesion creation but less lesion depth, which may reduce collateral damage | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Atrial fibrillation | |
| 650 | 4 | |a Autonomic system | |
| 650 | 4 | |a High power short duration | |
| 650 | 4 | |a Pulmonary vein isolation | |
| 650 | 4 | |a Skin sympathetic nerve activity | |
| 700 | 1 | |a Li, Cheng-Hung |e verfasserin |4 aut | |
| 700 | 1 | |a Lin, Yenn-Jiang |e verfasserin |4 aut | |
| 700 | 1 | |a Chang, Shih-Lin |e verfasserin |4 aut | |
| 700 | 1 | |a Hu, Yu-Feng |e verfasserin |4 aut | |
| 700 | 1 | |a Chung, Fa-Po |e verfasserin |4 aut | |
| 700 | 1 | |a Liao, Jo-Nan |e verfasserin |4 aut | |
| 700 | 1 | |a Tuan, Ta-Chuan |e verfasserin |4 aut | |
| 700 | 1 | |a Chao, Tze-Fan |e verfasserin |4 aut | |
| 700 | 1 | |a Lin, Chin-Yu |e verfasserin |4 aut | |
| 700 | 1 | |a Chang, Ting-Yung |e verfasserin |4 aut | |
| 700 | 1 | |a Ling-Kuo |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Chih-Min |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Shin-Huei |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Wei-Tso |e verfasserin |4 aut | |
| 700 | 1 | |a Chang, Wen-Han |e verfasserin |4 aut | |
| 700 | 1 | |a Chương, Nguyễn Khắc Thiên |e verfasserin |4 aut | |
| 700 | 1 | |a Kuo, Ming-Ren |e verfasserin |4 aut | |
| 700 | 1 | |a Kao, Pei-Heng |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Guan-Yi |e verfasserin |4 aut | |
| 700 | 1 | |a Ahliah, Ibrahim |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Shih-Ann |e verfasserin |4 aut | |
| 700 | 1 | |a Lo, Li-Wei |e verfasserin |4 aut | |
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