Nanoplastics induced oxidative stress and VEGF production in aortic endothelial cells
Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved..
Plastic is an important environmental issue and a more critical aspect concerns plastic fragments, mainly in term of nanoplastics (NPs). We demonstrated that NPs interfere with reproductive and adipose stromal cells. Since several research underlined an increased cardiovascular risk due to NPs, present study was undertaken to investigate their effect on aortic endothelial cells (AOC). We explored the specificity of their interaction with endothelial cells, quantifying their load in treated cells. Then, NPs effect was assessed on cell growth, generation of free radicals and antioxidant defence. Our data demonstrate that NPs colocalize with AOC. We found a significant (p < 0.01) increase both in metabolic activity and Vascular Endothelial Growth Factor (VEGF) production (p < 0.01). Redox status appeared to be disrupted (p < 0.05) by NPs. Taken together, the normal function of cultured AOC appeared negatively affected by AOC. Since NPs have been detected in blood, our present data appear of particular interest.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:104 |
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| Enthalten in: |
Environmental toxicology and pharmacology - 104(2023) vom: 15. Nov., Seite 104294 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Basini, Giuseppina [VerfasserIn] |
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| Links: |
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| Themen: |
Antioxidant scavengers |
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| Anmerkungen: |
Date Completed 16.12.2023 Date Revised 16.12.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.etap.2023.104294 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved. | ||
| 520 | |a Plastic is an important environmental issue and a more critical aspect concerns plastic fragments, mainly in term of nanoplastics (NPs). We demonstrated that NPs interfere with reproductive and adipose stromal cells. Since several research underlined an increased cardiovascular risk due to NPs, present study was undertaken to investigate their effect on aortic endothelial cells (AOC). We explored the specificity of their interaction with endothelial cells, quantifying their load in treated cells. Then, NPs effect was assessed on cell growth, generation of free radicals and antioxidant defence. Our data demonstrate that NPs colocalize with AOC. We found a significant (p < 0.01) increase both in metabolic activity and Vascular Endothelial Growth Factor (VEGF) production (p < 0.01). Redox status appeared to be disrupted (p < 0.05) by NPs. Taken together, the normal function of cultured AOC appeared negatively affected by AOC. Since NPs have been detected in blood, our present data appear of particular interest | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Antioxidant scavengers | |
| 650 | 4 | |a Plastic pollution | |
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| 650 | 4 | |a Redox status | |
| 650 | 4 | |a Vascular growth | |
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| 650 | 7 | |a Microplastics |2 NLM | |
| 700 | 1 | |a Grolli, Stefano |e verfasserin |4 aut | |
| 700 | 1 | |a Bertini, Simone |e verfasserin |4 aut | |
| 700 | 1 | |a Bussolati, Simona |e verfasserin |4 aut | |
| 700 | 1 | |a Berni, Melissa |e verfasserin |4 aut | |
| 700 | 1 | |a Berni, Priscilla |e verfasserin |4 aut | |
| 700 | 1 | |a Ramoni, Roberto |e verfasserin |4 aut | |
| 700 | 1 | |a Scaltriti, Erika |e verfasserin |4 aut | |
| 700 | 1 | |a Quintavalla, Fausto |e verfasserin |4 aut | |
| 700 | 1 | |a Grasselli, Francesca |e verfasserin |4 aut | |
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