Do pseudoxanthoma elasticum patients have higher prevalence of kidney stones on computed tomography compared to hospital controls?
© 2023. The Author(s)..
BACKGROUND: Pseudoxanthoma elasticum (PXE) is an autosomal recessive disease characterized by diminished inorganic plasma pyrophosphate (PPi), a strong calcification inhibitor. In addition to more typical calcification of skin, retina and arterial wall a diminished plasma PPi could lead to other ectopic calcification, such as formation of kidney stones.
OBJECTIVE: To compare the prevalence of kidney stones between PXE patients and hospital controls on computed tomography (CT).
METHOD: Low-dose CT images of PXE patients and controls were assessed by one radiologist, who was blinded for the diagnosis PXE. The number of kidney stones, and the size of the largest stone was recorded. Odds ratios (ORs) for having kidney stone were calculated using multivariable adjusted logistic regression.
RESULTS: Our study comprised 273 PXE patients and 125 controls. The mean age of PXE patients was 51.5 ± 15.9 years compared to 54.9 ± 14.2 in the control group (p = 0.04) and PXE patients more often were women (63 vs. 50%, p = 0.013). The prevalence of kidney stones on CT was similar: 6.9% in PXE patients, compared to 5.6% in controls (p = 0.6). In the multivariate analysis adjusting for age and sex, there was no significantly higher odds for PXE patients on having stones, compared to controls: OR 1.48 (95% CI 0.62-3.96).
CONCLUSION: There is no significant difference in the prevalence of incidental kidney stones on CT in PXE patients versus controls.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:28 |
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| Enthalten in: |
Clinical and experimental nephrology - 28(2024), 1 vom: 05. Jan., Seite 75-79 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Harmsen, Iris M [VerfasserIn] |
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| Links: |
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| Themen: |
ABCC6 |
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| Anmerkungen: |
Date Completed 05.01.2024 Date Revised 08.01.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s10157-023-02405-2 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM363305378 |
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| 245 | 1 | 0 | |a Do pseudoxanthoma elasticum patients have higher prevalence of kidney stones on computed tomography compared to hospital controls? |
| 264 | 1 | |c 2024 | |
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| 500 | |a Date Completed 05.01.2024 | ||
| 500 | |a Date Revised 08.01.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2023. The Author(s). | ||
| 520 | |a BACKGROUND: Pseudoxanthoma elasticum (PXE) is an autosomal recessive disease characterized by diminished inorganic plasma pyrophosphate (PPi), a strong calcification inhibitor. In addition to more typical calcification of skin, retina and arterial wall a diminished plasma PPi could lead to other ectopic calcification, such as formation of kidney stones | ||
| 520 | |a OBJECTIVE: To compare the prevalence of kidney stones between PXE patients and hospital controls on computed tomography (CT) | ||
| 520 | |a METHOD: Low-dose CT images of PXE patients and controls were assessed by one radiologist, who was blinded for the diagnosis PXE. The number of kidney stones, and the size of the largest stone was recorded. Odds ratios (ORs) for having kidney stone were calculated using multivariable adjusted logistic regression | ||
| 520 | |a RESULTS: Our study comprised 273 PXE patients and 125 controls. The mean age of PXE patients was 51.5 ± 15.9 years compared to 54.9 ± 14.2 in the control group (p = 0.04) and PXE patients more often were women (63 vs. 50%, p = 0.013). The prevalence of kidney stones on CT was similar: 6.9% in PXE patients, compared to 5.6% in controls (p = 0.6). In the multivariate analysis adjusting for age and sex, there was no significantly higher odds for PXE patients on having stones, compared to controls: OR 1.48 (95% CI 0.62-3.96) | ||
| 520 | |a CONCLUSION: There is no significant difference in the prevalence of incidental kidney stones on CT in PXE patients versus controls | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a ABCC6 | |
| 650 | 4 | |a CT | |
| 650 | 4 | |a Computed tomography | |
| 650 | 4 | |a Kidney stones | |
| 650 | 4 | |a PXE | |
| 650 | 4 | |a Pseudoxanthoma elasticum | |
| 650 | 4 | |a Urolithiasis | |
| 700 | 1 | |a Kok, Madeleine |e verfasserin |4 aut | |
| 700 | 1 | |a Bartstra, Jonas W |e verfasserin |4 aut | |
| 700 | 1 | |a de Jong, Pim A |e verfasserin |4 aut | |
| 700 | 1 | |a Spiering, Wilko |e verfasserin |4 aut | |
| 700 | 1 | |a Foppen, Wouter |e verfasserin |4 aut | |
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