A spectroscopy based prototype for the noninvasive detection of diabetes from human saliva using nanohybrids acting as nanozyme
© 2023. Springer Nature Limited..
The recent prediction of diabetes to be a global pandemic invites a detection strategy preferably non-invasive, and bloodless to manage the disease and the associated complications. Here, we have synthesized chitosan polymer functionalized, organic-inorganic bio-compatible nano-hybrids of Mn3O4 nanoparticles, and characterized it by utilizing several optical methodologies for the structural characterization which shows the Michaelis Menten (MM) kinetics for glucose and alpha-amylase protein (well-known diabetes biomarkers). We have also studied the potentiality for the detection of alpha-amylase in human salivary secretion which is reported to be strongly correlated with uncontrolled hyperglycemia. Finally, we have developed a prototype for the measurement of glucose (LOD of 0.38 mg/dL, LOQ of 1.15 mg/dL) and HbA1c (LOD of 0.15% and LOQ of 0.45%) utilizing the basic knowledge in the study for the detection of uncontrolled hyperglycemia at the point-of-care. With the limited number of clinical trials, we have explored the potential of our work in combating the diabetic pandemic across the globe in near future.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:13 |
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| Enthalten in: |
Scientific reports - 13(2023), 1 vom: 12. Okt., Seite 17306 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Roy, Lopamudra [VerfasserIn] |
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| Links: |
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| Themen: |
Alpha-Amylases |
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| Anmerkungen: |
Date Completed 01.11.2023 Date Revised 18.11.2023 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1038/s41598-023-44011-y |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a The recent prediction of diabetes to be a global pandemic invites a detection strategy preferably non-invasive, and bloodless to manage the disease and the associated complications. Here, we have synthesized chitosan polymer functionalized, organic-inorganic bio-compatible nano-hybrids of Mn3O4 nanoparticles, and characterized it by utilizing several optical methodologies for the structural characterization which shows the Michaelis Menten (MM) kinetics for glucose and alpha-amylase protein (well-known diabetes biomarkers). We have also studied the potentiality for the detection of alpha-amylase in human salivary secretion which is reported to be strongly correlated with uncontrolled hyperglycemia. Finally, we have developed a prototype for the measurement of glucose (LOD of 0.38 mg/dL, LOQ of 1.15 mg/dL) and HbA1c (LOD of 0.15% and LOQ of 0.45%) utilizing the basic knowledge in the study for the detection of uncontrolled hyperglycemia at the point-of-care. With the limited number of clinical trials, we have explored the potential of our work in combating the diabetic pandemic across the globe in near future | ||
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| 700 | 1 | |a Banerjee, Amrita |e verfasserin |4 aut | |
| 700 | 1 | |a Singh, Soumendra |e verfasserin |4 aut | |
| 700 | 1 | |a Chattopadhyay, Arpita |e verfasserin |4 aut | |
| 700 | 1 | |a Ahmed, Saleh A |e verfasserin |4 aut | |
| 700 | 1 | |a Jassas, Rabab S |e verfasserin |4 aut | |
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| 700 | 1 | |a Althagafi, Ismail I |e verfasserin |4 aut | |
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| 700 | 1 | |a Mallick, Asim Kumar |e verfasserin |4 aut | |
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