Platelet count and MCHC as independent prognostic markers for feline mammary carcinomas
Copyright © 2023 Elsevier Ltd. All rights reserved..
Mammary neoplasms are common in felines species and represent a significant disease for its unfavorable prognosis. Changes in the blood count and serum biochemical profile of these patients have potential as non-invasive prognostic markers prior to mastectomy, however, they are poorly described in literature. In this study univariate and multivariate analyses were performed using these factors to determine the effect of each parameter on the one-year survival time after the surgical procedure in these animals. The median overall survival (OS) and the disease-free survival (DFS) were 365 and 242 days, respectively. In univariate analysis, values within the reference range of monocyte, platelet and creatinine counts were identified as significant prognostic factors for OS and only creatinine was significant for DFS (P < 0.05). In the multivariate analysis, platelets and mean corpuscular hemoglobin concentration (MCHC) remained independent prognostic factors for OS. The results presented suggest that monocytes, platelets and creatinine may be important non-invasive pre-surgical prognostic markers, and that platelet count and MCHC are independent prognostic markers for feline mammary carcinomas (FMC). The correlation between such alterations is of important relevance for veterinary oncology, and prospective studies are needed to validate their clinical use and that platelet count and MCHC are independent prognostic markers for FMC. The results found in this study can also be studied in human medicine, regarding blood markers in human breast cancer (HBC).
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:164 |
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| Enthalten in: |
Research in veterinary science - 164(2023) vom: 01. Nov., Seite 105024 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
da Silva Soares, Elaine [VerfasserIn] |
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| Links: |
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| Themen: |
AYI8EX34EU |
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| Anmerkungen: |
Date Completed 06.11.2023 Date Revised 06.11.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.rvsc.2023.105024 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Mammary neoplasms are common in felines species and represent a significant disease for its unfavorable prognosis. Changes in the blood count and serum biochemical profile of these patients have potential as non-invasive prognostic markers prior to mastectomy, however, they are poorly described in literature. In this study univariate and multivariate analyses were performed using these factors to determine the effect of each parameter on the one-year survival time after the surgical procedure in these animals. The median overall survival (OS) and the disease-free survival (DFS) were 365 and 242 days, respectively. In univariate analysis, values within the reference range of monocyte, platelet and creatinine counts were identified as significant prognostic factors for OS and only creatinine was significant for DFS (P < 0.05). In the multivariate analysis, platelets and mean corpuscular hemoglobin concentration (MCHC) remained independent prognostic factors for OS. The results presented suggest that monocytes, platelets and creatinine may be important non-invasive pre-surgical prognostic markers, and that platelet count and MCHC are independent prognostic markers for feline mammary carcinomas (FMC). The correlation between such alterations is of important relevance for veterinary oncology, and prospective studies are needed to validate their clinical use and that platelet count and MCHC are independent prognostic markers for FMC. The results found in this study can also be studied in human medicine, regarding blood markers in human breast cancer (HBC) | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Biomarkers | |
| 650 | 4 | |a Cat mammary tumors | |
| 650 | 4 | |a Mean corpuscular hemoglobin concentration | |
| 650 | 4 | |a Overall survival | |
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| 700 | 1 | |a Valente, Fabrício Luciani |e verfasserin |4 aut | |
| 700 | 1 | |a Dos Anjos, Luan Richelle Aparecido |e verfasserin |4 aut | |
| 700 | 1 | |a de Oliveira, Fabiano Luiz Dulce |e verfasserin |4 aut | |
| 700 | 1 | |a de Oliveira Loures, Carla |e verfasserin |4 aut | |
| 700 | 1 | |a Rocha, Pâmela Thalita |e verfasserin |4 aut | |
| 700 | 1 | |a Castro, Verônica Rodrigues |e verfasserin |4 aut | |
| 700 | 1 | |a Sarandy, Thaís Barroso |e verfasserin |4 aut | |
| 700 | 1 | |a Borges, Andréa Pacheco Batista |e verfasserin |4 aut | |
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