Dual drug loaded polypeptide delivery systems for cancer therapy
The present study was aimed to prepare and examine in vitro novel dual-drug loaded delivery systems. Biodegradable nanoparticles based on poly(L-glutamic acid-co-D-phenylalanine) were used as nanocarriers for encapsulation of two drugs from the paclitaxel, irinotecan, and doxorubicin series. The developed delivery systems were characterised with hydrodynamic diameters less than 300 nm (PDI < 0.3). High encapsulation efficiencies (≥75%) were achieved for all single- and dual-drug formulations. The release studies showed faster release at acidic pH, with the release rate decreasing over time. The release patterns of the co-encapsulated forms of substances differed from those of the separately encapsulated drugs, suggesting differences in drug-polymer interactions. The joint action of encapsulated drugs was analysed using the colon cancer cells, both for the dual-drug delivery sytems and a mixture of single-drug formulations. The encapsulated forms of the drug combinations demonstrated comparable efficacy to the free forms, with the encapsulation enhancing solubility of the hydrophobic drug paclitaxel.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2023 |
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| Enthalten in: |
Journal of microencapsulation - (2023) vom: 12. Okt., Seite 1-19 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Zashikhina, Natalia [VerfasserIn] |
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| Links: |
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| Themen: |
Antitumor drugs |
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| Anmerkungen: |
Date Revised 18.10.2023 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1080/02652048.2023.2270064 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM363177191 |
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| 520 | |a The present study was aimed to prepare and examine in vitro novel dual-drug loaded delivery systems. Biodegradable nanoparticles based on poly(L-glutamic acid-co-D-phenylalanine) were used as nanocarriers for encapsulation of two drugs from the paclitaxel, irinotecan, and doxorubicin series. The developed delivery systems were characterised with hydrodynamic diameters less than 300 nm (PDI < 0.3). High encapsulation efficiencies (≥75%) were achieved for all single- and dual-drug formulations. The release studies showed faster release at acidic pH, with the release rate decreasing over time. The release patterns of the co-encapsulated forms of substances differed from those of the separately encapsulated drugs, suggesting differences in drug-polymer interactions. The joint action of encapsulated drugs was analysed using the colon cancer cells, both for the dual-drug delivery sytems and a mixture of single-drug formulations. The encapsulated forms of the drug combinations demonstrated comparable efficacy to the free forms, with the encapsulation enhancing solubility of the hydrophobic drug paclitaxel | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Polypeptides | |
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| 650 | 4 | |a co-encapsulation | |
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| 650 | 4 | |a doxorubicin | |
| 650 | 4 | |a dual drug delivery systems | |
| 650 | 4 | |a irinotecan | |
| 650 | 4 | |a paclitaxel | |
| 650 | 4 | |a polymeric particles | |
| 700 | 1 | |a Gandalipov, Erik |e verfasserin |4 aut | |
| 700 | 1 | |a Dzhuzha, Apollinariia |e verfasserin |4 aut | |
| 700 | 1 | |a Korzhikov-Vlakh, Viktor |e verfasserin |4 aut | |
| 700 | 1 | |a Korzhikova-Vlakh, Evgenia |e verfasserin |4 aut | |
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