A single-cell multi-omic atlas spanning the adult rhesus macaque brain
Cataloging the diverse cellular architecture of the primate brain is crucial for understanding cognition, behavior, and disease in humans. Here, we generated a brain-wide single-cell multimodal molecular atlas of the rhesus macaque brain. Together, we profiled 2.58 M transcriptomes and 1.59 M epigenomes from single nuclei sampled from 30 regions across the adult brain. Cell composition differed extensively across the brain, revealing cellular signatures of region-specific functions. We also identified 1.19 M candidate regulatory elements, many previously unidentified, allowing us to explore the landscape of cis-regulatory grammar and neurological disease risk in a cell type-specific manner. Altogether, this multi-omic atlas provides an open resource for investigating the evolution of the human brain and identifying novel targets for disease interventions.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:9 |
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| Enthalten in: |
Science advances - 9(2023), 41 vom: 13. Okt., Seite eadh1914 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Chiou, Kenneth L [VerfasserIn] |
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| Anmerkungen: |
Date Completed 12.02.2024 Date Revised 12.02.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1126/sciadv.adh1914 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM363176535 |
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| 520 | |a Cataloging the diverse cellular architecture of the primate brain is crucial for understanding cognition, behavior, and disease in humans. Here, we generated a brain-wide single-cell multimodal molecular atlas of the rhesus macaque brain. Together, we profiled 2.58 M transcriptomes and 1.59 M epigenomes from single nuclei sampled from 30 regions across the adult brain. Cell composition differed extensively across the brain, revealing cellular signatures of region-specific functions. We also identified 1.19 M candidate regulatory elements, many previously unidentified, allowing us to explore the landscape of cis-regulatory grammar and neurological disease risk in a cell type-specific manner. Altogether, this multi-omic atlas provides an open resource for investigating the evolution of the human brain and identifying novel targets for disease interventions | ||
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Bohlen, Martin O |e verfasserin |4 aut | |
| 700 | 1 | |a Tremblay, Sébastien |e verfasserin |4 aut | |
| 700 | 1 | |a DeCasien, Alex R |e verfasserin |4 aut | |
| 700 | 1 | |a O'Day, Diana R |e verfasserin |4 aut | |
| 700 | 1 | |a Spurrell, Cailyn H |e verfasserin |4 aut | |
| 700 | 1 | |a Gogate, Aishwarya A |e verfasserin |4 aut | |
| 700 | 1 | |a Zintel, Trisha M |e verfasserin |4 aut | |
| 700 | 0 | |a Cayo Biobank Research Unit |e verfasserin |4 aut | |
| 700 | 1 | |a Andrews, Madeline G |e verfasserin |4 aut | |
| 700 | 1 | |a Martínez, Melween I |e verfasserin |4 aut | |
| 700 | 1 | |a Starita, Lea M |e verfasserin |4 aut | |
| 700 | 1 | |a Montague, Michael J |e verfasserin |4 aut | |
| 700 | 1 | |a Platt, Michael L |e verfasserin |4 aut | |
| 700 | 1 | |a Shendure, Jay |e verfasserin |4 aut | |
| 700 | 1 | |a Snyder-Mackler, Noah |e verfasserin |4 aut | |
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