A novel speckle-tracking echocardiography parameter assessing left ventricular afterload
© 2023 The Authors. European Journal of Clinical Investigation published by John Wiley & Sons Ltd on behalf of Stichting European Society for Clinical Investigation Journal Foundation..
BACKGROUND: Left ventricular stroke work index (LVSWI) and afterload-related cardiac performance (ACP) consider left ventricular (LV) afterload and could be better prognosticators in septic cardiomyopathy. However, their invasive nature prevents their routine clinical applications. This study aimed to investigate (1) whether a proposed speckle-tracking echocardiography parameter, Pressure-Strain Product (PSP), can non-invasively predict catheter-based LVSWI, ACP and serum lactate in an ovine model of septic cardiomyopathy; and (2) whether PSP can distinguish the sub-phenotypes of acute respiratory distress syndrome (ARDS) with or without sepsis-like conditions.
METHODS: Sixteen sheep with ARDS were randomly assigned to either (1) sepsis-like (n = 8) or (2) non-sepsis-like (n = 8) group. Each ARDS and sepsis-like condition was induced by intravenous infusion of oleic acid and lipopolysaccharide, respectively. Pulmonary artery catheter-based LVSWI (the product of stroke work index, mean arterial pressure and .0136), ACP (the percentage of cardiac output measured to cardiac output predicted as normal) and serum lactate were measured simultaneously with transthoracic echocardiography. Two PSP indices were calculated by multiplying the mean arterial blood pressure and either global circumferential strain (PSPcirc) or radial strain (PSPrad).
RESULTS: PSPcirc showed a significant correlation with LVSWI (r2 = .66, p < .001) and ACP (r2 = .82, p < .001) in the sepsis-like group. Although PSP could not distinguish subphenotypes, PSPcirc predicted LVSWI (AUC .86) and ACP (AUC .88), and PSPrad predicted serum lactate (AUC .75) better than LV ejection fraction, global circumferential and radial strain.
CONCLUSIONS: A novel PSP has the potential to non-invasively predict catheter-based LVSWI and ACP, and was associated with serum lactate in septic cardiomyopathy.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:54 |
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| Enthalten in: |
European journal of clinical investigation - 54(2024), 2 vom: 23. Jan., Seite e14106 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Sato, Kei [VerfasserIn] |
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| Links: |
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| Themen: |
Afterload-related cardiac performance |
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| Anmerkungen: |
Date Completed 24.01.2024 Date Revised 24.01.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1111/eci.14106 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM363151095 |
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| 245 | 1 | 2 | |a A novel speckle-tracking echocardiography parameter assessing left ventricular afterload |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2023 The Authors. European Journal of Clinical Investigation published by John Wiley & Sons Ltd on behalf of Stichting European Society for Clinical Investigation Journal Foundation. | ||
| 520 | |a BACKGROUND: Left ventricular stroke work index (LVSWI) and afterload-related cardiac performance (ACP) consider left ventricular (LV) afterload and could be better prognosticators in septic cardiomyopathy. However, their invasive nature prevents their routine clinical applications. This study aimed to investigate (1) whether a proposed speckle-tracking echocardiography parameter, Pressure-Strain Product (PSP), can non-invasively predict catheter-based LVSWI, ACP and serum lactate in an ovine model of septic cardiomyopathy; and (2) whether PSP can distinguish the sub-phenotypes of acute respiratory distress syndrome (ARDS) with or without sepsis-like conditions | ||
| 520 | |a METHODS: Sixteen sheep with ARDS were randomly assigned to either (1) sepsis-like (n = 8) or (2) non-sepsis-like (n = 8) group. Each ARDS and sepsis-like condition was induced by intravenous infusion of oleic acid and lipopolysaccharide, respectively. Pulmonary artery catheter-based LVSWI (the product of stroke work index, mean arterial pressure and .0136), ACP (the percentage of cardiac output measured to cardiac output predicted as normal) and serum lactate were measured simultaneously with transthoracic echocardiography. Two PSP indices were calculated by multiplying the mean arterial blood pressure and either global circumferential strain (PSPcirc) or radial strain (PSPrad) | ||
| 520 | |a RESULTS: PSPcirc showed a significant correlation with LVSWI (r2 = .66, p < .001) and ACP (r2 = .82, p < .001) in the sepsis-like group. Although PSP could not distinguish subphenotypes, PSPcirc predicted LVSWI (AUC .86) and ACP (AUC .88), and PSPrad predicted serum lactate (AUC .75) better than LV ejection fraction, global circumferential and radial strain | ||
| 520 | |a CONCLUSIONS: A novel PSP has the potential to non-invasively predict catheter-based LVSWI and ACP, and was associated with serum lactate in septic cardiomyopathy | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a afterload-related cardiac performance | |
| 650 | 4 | |a left ventricular stroke work index | |
| 650 | 4 | |a septic cardiomyopathy | |
| 650 | 4 | |a speckle-tracking echocardiography | |
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| 700 | 1 | |a Wildi, Karin |e verfasserin |4 aut | |
| 700 | 1 | |a Chan, Jonathan |e verfasserin |4 aut | |
| 700 | 1 | |a Palmieri, Chiara |e verfasserin |4 aut | |
| 700 | 1 | |a Obonyo, Nchafatso G |e verfasserin |4 aut | |
| 700 | 1 | |a Heinsar, Silver |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Keibun |e verfasserin |4 aut | |
| 700 | 1 | |a Livingstone, Samantha |e verfasserin |4 aut | |
| 700 | 1 | |a Sato, Noriko |e verfasserin |4 aut | |
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| 700 | 1 | |a Bouquet, Mahé |e verfasserin |4 aut | |
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| 700 | 1 | |a Bassi, Gianluigi Li |e verfasserin |4 aut | |
| 700 | 1 | |a Fraser, John F |e verfasserin |4 aut | |
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