New approach to testing treatments for osteoarthritis : FastOA
© Author(s) (or their employer(s)) 2024. No commercial re-use. See rights and permissions. Published by BMJ..
Animal models of post traumatic osteoarthritis have shown many promising treatments for disease, but human trials have mostly failed to identify effective treatments. This viewpoint suggests that the frequent failure of drug and treatment development in osteoarthritis is due, in part, to the advanced stage of disease of patients in trials and suggests that mirroring the animal model approach might be more successful. It suggests a path forward by enriching trial enrollees with those likely to develop post traumatic OA quickly.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:83 |
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| Enthalten in: |
Annals of the rheumatic diseases - 83(2024), 3 vom: 15. Feb., Seite 274-276 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Felson, David [VerfasserIn] |
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| Links: |
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| Themen: |
Journal Article |
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| Anmerkungen: |
Date Completed 19.02.2024 Date Revised 09.03.2024 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1136/ard-2023-224675 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a © Author(s) (or their employer(s)) 2024. No commercial re-use. See rights and permissions. Published by BMJ. | ||
| 520 | |a Animal models of post traumatic osteoarthritis have shown many promising treatments for disease, but human trials have mostly failed to identify effective treatments. This viewpoint suggests that the frequent failure of drug and treatment development in osteoarthritis is due, in part, to the advanced stage of disease of patients in trials and suggests that mirroring the animal model approach might be more successful. It suggests a path forward by enriching trial enrollees with those likely to develop post traumatic OA quickly | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Orthopedic Procedures | |
| 650 | 4 | |a Osteoarthritis | |
| 650 | 4 | |a Therapeutics | |
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| 700 | 1 | |a Jin, Yuxuan |e verfasserin |4 aut | |
| 700 | 1 | |a Jones, Morgan |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Jason S |e verfasserin |4 aut | |
| 700 | 1 | |a Spindler, Kurt |e verfasserin |4 aut | |
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